Results 51 to 60 of about 8,559 (195)

Light-Dependent Activation of the GCN2 Kinase Under Cold and Salt Stress Is Mediated by the Photosynthetic Status of the Chloroplast

Frontiers in Plant Science, 2020
Regulation of cytosolic mRNA translation is a key node for rapid adaptation to environmental stress conditions. In yeast and animals, phosphorylation of the α-subunit of eukaryotic translation initiation factor eIF2 is the most thoroughly characterized ...
Ansul Lokdarshi, Philip W. Morgan, Michelle Franks, Zoe Emert, Catherine Emanuel, Albrecht G. von Arnim, Albrecht G. von Arnim   +6 more
doaj   +1 more source

GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

Autophagy Reports, 2022
The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin, Laurent Parry, Wafa B’chir, Valérie Carraro, Cécile Coudy-Gandilhon, Ghita Chaouki, Cédric Chaveroux, Sylvie Mordier, Brigitte Martinie, Vanessa Reinhardt, Céline Jousse, Alain Bruhat, Patrice Codogno, Julien Averous, Pierre Fafournoux   +14 more
doaj   +1 more source

Mitochondrial ROS-mediated ribosome stalling and GCN2 activation are partially involved in 1-nitropyrene-induced steroidogenic inhibition in testes

Environment International, 2022
In the past 50 years, testosterone (T) level in men has declined gradually. In this research, we discovered that acute exposure to 1-nitropyrene (1-NP), an environmental stressor from polluted atmosphere, reduced T contents by downregulating ...
Jian Li, Lan Gao, Jing Chen, Wei-Wei Zhang, Xiao-Yi Zhang, Bo Wang, Cheng Zhang, Yan Wang, Yi-Chao Huang, Hua Wang, Wei Wei, De-Xiang Xu   +11 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid‐starved cells [PDF]

The EMBO Journal, 2000
GCN2 stimulates GCN4 translation in amino acid-starved cells by phosphorylating the alpha-subunit of translation initiation factor 2. GCN2 function in vivo requires the GCN1/GCN20 complex, which binds to the N-terminal domain of GCN2. A C-terminal segment of GCN1 (residues 2052-2428) was found to be necessary and sufficient for binding GCN2 in vivo and
E, Sattlegger, A G, Hinnebusch
openaire   +2 more sources

Role of GCN2 in Maize Cold Response [PDF]

, 2014
Wild type maize is deficient in several key amino acids necessary for proper human nutrition. The maize opaque2 mutation gives the grain a more complete protein content, but it makes the endosperm fragile.
Jones, Calley, Jones, Calley.
core   +1 more source

GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat. [PDF]

PLoS ONE, 2013
The liver plays a central role in regulating lipid metabolism and facilitates efficient lipid utilization and storage. We discovered that a modest increase in maternal dietary fat in mice programs triglyceride storage in the liver of their developing ...
Xu Xu, Jingjie Hu, Barbara C McGrath, Douglas R Cavener   +3 more
doaj   +1 more source

Twenty‐Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology

Yeast, EarlyView.
ABSTRACT All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free‐living microbes directly exposed to a changing environment.
Audrey P. Gasch
wiley   +1 more source

The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer

Cancer Science, EarlyView.
CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley   +1 more source