Results 51 to 60 of about 7,295 (170)

Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment

MedComm, Volume 7, Issue 10, October 2026.
The liver is not merely a passive recipient of disseminated tumor cells, but a unique metastatic organ shaped by anatomical, metabolic, and immunological characteristics that support tumor colonization. Increasing evidence indicates that colorectal cancer liver metastasis development is driven by dynamic interactions between tumor intrinsic programs ...
Jialiang Fan, Huiru Zhang, Deyang Kong, Yu Sun, Shuaibing Lu, Wenjing Yang, Renshen Xiang, Qi Zhang, Wei Pei, Haizeng Zhang, Lin Feng   +10 more
wiley   +1 more source

Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes

Cell Reports
Summary: Poor skin wound healing, which is common in patients with diabetes, is related to imbalanced macrophage polarization. Here, we find that nutrition sensor GCN2 (general control nonderepressible 2) and its downstream are significantly upregulated ...
Yangxiao Hou, Dong Wei, Zhaoqi Zhang, Tong Lei, Sihong Li, Jiaming Bao, Han Guo, Liang Tan, Xubiao Xie, Yuan Zhuang, Zhongbing Lu, Yong Zhao   +11 more
doaj   +1 more source

Amino Acid Sensor Kinase Gcn2 Is Required for Conidiation, Secondary Metabolism, and Cell Wall Integrity in the Taxol-Producer Pestalotiopsis microspora

Frontiers in Microbiology, 2017
The canonical Gcn2/Cpc1 kinase in fungi coordinates the expression of target genes in response to amino acid starvation. To investigate its possible role in secondary metabolism, we characterized a gcn2 homolog in the taxol-producing fungus ...
Dan Wang, Oren Akhberdi, Xiaoran Hao, Xi Yu, Longfei Chen, Yanjie Liu, Xudong Zhu   +6 more
doaj   +1 more source

Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis

Cell Discovery, 2021
The amino acid response (AAR) and unfolded protein response (UPR) pathways converge on eIF2α phosphorylation, which is catalyzed by Gcn2 and Perk, respectively, under different stresses.
Fan Zhang, Qi-Yu Zeng, Hao Xu, Ai-Ning Xu, Dian-Jia Liu, Ning-Zhe Li, Yi Chen, Yi Jin, Chun-Hui Xu, Chang-Zhou Feng, Yuan-Liang Zhang, Dan Liu, Na Liu, Yin-Yin Xie, Shan-He Yu, Hao Yuan, Kai Xue, Jing-Yi Shi, Ting Xi Liu, Peng-Fei Xu, Wei-Li Zhao, Yi Zhou, Lan Wang, Qiu-Hua Huang, Zhu Chen, Sai-Juan Chen, Xiao-Long Zhou, Xiao-Jian Sun   +27 more
doaj   +1 more source

The Effects of Extracellular Vesicles From Cancer Cells in Acidosis or ER Stress to Endothelial Cells: Angiogenesis and Endothelial Activation

Biology of the Cell, Volume 118, Issue 10, October 2026.
When breast cancer cells experience ER stress, their large extracellular vesicles promote increased endothelial migration and endothelial permeability. When these cancer cells are adapted to acidosis, their extracellular vesicles increase permeability and migration, reduce angiogenesis and tumor cell adhesion to endothelia, and activate ER stress ...
Ana Sayuri Yamagata, Ramon H. G. Teles, Nicolas J. Villarinho, Ana Carolina Lima Ralph, Nicolly C. dos Santos, Kevin Perera, Gisela R. Terçarioli, Amanda Ikegami, Anayara Ristow, Daniel Pecoraro Demarque, Jeremy Newton, Luiz E. da Silva, Edmond W. K. Young, Ruy G. Jaeger, Vanessa Morais Freitas   +14 more
wiley   +1 more source

Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo. [PDF]

PLoS Genetics, 2015
The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α. Gcn2 is activated in amino acid-deprived cells by binding of uncharged tRNA to the regulatory domain related to histidyl-tRNA ...
Sebastien Lageix, Jinwei Zhang, Stefan Rothenburg, Alan G Hinnebusch   +3 more
doaj   +1 more source

The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer

Cancer Science, Volume 117, Issue 10, Page 2636-2643, October 2026.
CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley   +1 more source

Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase

Scientific Reports, 2017
The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1).
Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek, Tracy G. Anthony   +7 more
doaj   +1 more source

Starving Intestinal Inflammation with the Amino Acid Sensor GCN2 [PDF]

Cell Metabolism, 2016
Metabolic stressors are emerging as important controls over immune system function. In a recent paper, Ravindran et al. (2016) uncovered a novel mechanism by which an amino acid sensing pathway controls inflammation in the gut.
Xavier S, Revelo, Shawn, Winer, Daniel A, Winer   +2 more
openaire   +2 more sources

The Unfolded Protein Response as a Modulator of Cancer‐Immune Cell Communication in the Tumour Microenvironment

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT The tumour microenvironment (TME) comprises a dynamic network of structural, cellular, and signalling components that interact to influence tumour development. Immune cells play a key role in recognizing and eliminating cancer cells through detection of tumour‐derived membrane and secreted proteins processed in the endoplasmic reticulum (ER ...
Yew Hwang Chee, Matthieu Moncan, Eileen Reidy, Adrienne M. Gorman, Afshin Samali   +4 more
wiley   +1 more source