GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid
Autophagy Reports, 2022 The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin +14 more
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Environment International, 2022 In the past 50 years, testosterone (T) level in men has declined gradually. In this research, we discovered that acute exposure to 1-nitropyrene (1-NP), an environmental stressor from polluted atmosphere, reduced T contents by downregulating ...
Jian Li +11 more
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New functions of protein kinase Gcn2 in yeast and mammals [PDF]
IUBMB Life, 2012 AbstractThe classical role of the conserved Gcn2 kinase of yeast and mammals is to activate the translation of the transcription factors Gcn4 in yeast and activating transcription factor 4 in mammals by phosphorylating the eukaryotic translation initiation factor 2α.
José R, Murguía, Ramón, Serrano
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GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat. [PDF]
PLoS ONE, 2013 The liver plays a central role in regulating lipid metabolism and facilitates efficient lipid utilization and storage. We discovered that a modest increase in maternal dietary fat in mice programs triglyceride storage in the liver of their developing ...
Xu Xu +3 more
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Solution structure of the RWD domain of the mouse GCN2 protein [PDF]
Protein Science, 2004 AbstractGCN2 is the α‐subunit of the only translation initiation factor (eIF2α) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N‐terminus, which is termed the RWD domain after three major RWD‐containing proteins: RING finger‐containing proteins, WD‐repeat‐containing proteins, and yeast DEAD ...
Nobukazu, Nameki +29 more
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GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration
Scientific Reports, 2017 GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection.
A. Jaspart +13 more
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Starving Intestinal Inflammation with the Amino Acid Sensor GCN2 [PDF]
Cell Metabolism, 2016 Metabolic stressors are emerging as important controls over immune system function. In a recent paper, Ravindran et al. (2016) uncovered a novel mechanism by which an amino acid sensing pathway controls inflammation in the gut.
Xavier S, Revelo +2 more
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Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
Cell ReportsSummary: Poor skin wound healing, which is common in patients with diabetes, is related to imbalanced macrophage polarization. Here, we find that nutrition sensor GCN2 (general control nonderepressible 2) and its downstream are significantly upregulated ...
Yangxiao Hou +11 more
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Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis
Cell Discovery, 2021 The amino acid response (AAR) and unfolded protein response (UPR) pathways converge on eIF2α phosphorylation, which is catalyzed by Gcn2 and Perk, respectively, under different stresses.
Fan Zhang +27 more
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Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo. [PDF]
PLoS Genetics, 2015 The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α. Gcn2 is activated in amino acid-deprived cells by binding of uncharged tRNA to the regulatory domain related to histidyl-tRNA ...
Sebastien Lageix +3 more
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