Results 41 to 50 of about 8,559 (195)

Global phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms of translational control

, 2021
The conserved Gcn2 protein kinase mediates cellular adaptations to amino acid limitation through translational control of gene expression that is exclusively executed by phosphorylation of the α-subunit of the eukaryotic translation initiation factor 2 ...
Hu, Zehan, Garcia Osuna, Guillermo Miguel, Dengjel, Jörn, Kressler, Dieter, De Virgilio, Claudio, Pillet, Benjamin, Dokládal, Ladislav, Stumpe, Michael   +7 more
core   +1 more source

Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2

Cancer Research Communications, 2023
Abstract The effect of targeted therapeutics on anticancer immune responses is poorly understood. The BRAF inhibitor dabrafenib has been reported to activate the integrated stress response (ISR) kinase GCN2, and the therapeutic effect has been partially attributed to GCN2 activation.
M. Teresa Ciudad, Rene Quevedo, Sara Lamorte, Robbie Jin, Nadine Nzirorera, Marianne Koritzinsky, Tracy L. McGaha   +6 more
openaire   +3 more sources

The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation

eLife, 2023
Circadian clocks are evolved to adapt to the daily environmental changes under different conditions. The ability to maintain circadian clock functions in response to various stresses and perturbations is important for organismal fitness.
Xiao-Lan Liu, Yulin Yang, Yue Hu, Jingjing Wu, Chuqiao Han, Qiaojia Lu, Xihui Gan, Shaohua Qi, Jinhu Guo, Qun He, Yi Liu, Xiao Liu   +11 more
doaj   +1 more source

GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2α in Arabidopsis

, 2008
The yeast regulatory protein kinase, general control non-derepressible-2 (GCN2) plays a key role in general amino acid control. GCN2 phosphorylates the α subunit of the trimeric eukaryotic translation initiation factor-2 (eIF2), bringing about a decrease
Parry, Martin A. J., Halford, Nigel G., Yuhua Zhang, Zhang, Yuhua, Kanyuka, K., Parry, M. A. J., Halford, N. G., Stephen J. Powers, Kanyuka, Kostya, Zhang, Y., Wang, Yifei, Powers, S. J., Kostya Kanyuka, Martin A. J. Parry, Powers, Stephen J., Yifei Wang, Wang, Y., Nigel G. Halford   +17 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions

Journal of Genetic Engineering and Biotechnology, 2020
Background Eukaryotic initiation factor 2B (eIF2B) initiates and regulates translation initiation in eukaryotes. eIF2B gene mutations cause leukoencephalopathy called vanishing white matter disease (VWM) in humans and slow growth (Slg−) and general ...
Sonum Sharma, Anuradha Sourirajan, David J. Baumler, Kamal Dev   +3 more
doaj   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

IDO-GCN2 and autophagy in inflammation

Oncotarget, 2015
Inflammation is a disruptive force in the tissue microenvironment driving extracellular matrix reorganization, production of noxious effector molecules (superoxide, nitric oxide, peroxynitrite, ect.), hypoxia, and active consumption of nutrients required for biosynthesis including amino acids.
openaire   +2 more sources

Triazolo[4,5-d]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells

Computational and Structural Biotechnology Journal, 2018
Cellular stress signals activate adaptive signaling pathways of the mammalian integrated stress response (ISR), of which the unfolded protein response (UPR) is a subset. These pathways converge at the phosporylation of eIF2α.
Lea Lough, Dan Sherman, Manuel Becerra-Flores, Deepika Vasudevan, Olga Lavinda, Eric Ni, Hong Wang, Hyung Don Ryoo, Raoul Tibes, Timothy Cardozo   +9 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source