Results 31 to 40 of about 8,559 (195)

Activation of the integrated stress response by inhibitors of its kinases

Nature Communications, 2023
Phosphorylation of the translation initiation factor eIF2α to initiate the integrated stress response (ISR) is a vital signalling event. Protein kinases activating the ISR, including PERK and GCN2, have attracted considerable attention for drug ...
Maria Szaruga, Dino A. Janssen, Claudia de Miguel, George Hodgson, Agnieszka Fatalska, Aleksandra P. Pitera, Antonina Andreeva, Anne Bertolotti   +7 more
doaj   +1 more source

GCN2 Whets the Appetite for Amino Acids [PDF]

Molecular Cell, 2005
In response to amino acid starvation, the kinase GCN2 in yeast activates amino acid biosynthesis. Two recent studies (Maurin et al., 2005; Hao et al., 2005) reveal that GCN2 in the brain of mice restricts intake of diets lacking essential amino acids.
Dever, Thomas E., Hinnebusch, Alan G.
openaire   +2 more sources

Global Role of the Protein Kinase Gcn2 in the Human Pathogen Candida albicans [PDF]

, 2005
The pathogen Candida albicans responds to amino acid starvation by activating pseudohyphal development and the expression of amino acid biosynthetic genes (GCN response). In Saccharomyces cerevisiae, the GCN response is dependent on Gcn2, which regulates
Brown, A.J.P., Brown, A.JP., Tournu, H., Bertram, G., Macaskill, S., Odds, F.C., Gow, N.A.R., Mavor, A., Walker, L., Tournu, Helene, Tripathi, G., Gow, N.AR.   +11 more
core   +1 more source

GCN2 and TOR converge on aging

Aging, 2013
Coordinated responses in all tissues upon nutrient stress ensure the survival of an organism in periods of food unavailability. Two evolutionarily conserved, nutrient-sensing signaling pathways that promote stress adaptation following starvation are the general amino acid control pathway that activates GCN2 kinase and the target of rapamycin (TOR ...
Vlanti, A., Rousakis, A., Syntichaki, P.
openaire   +3 more sources

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

eLife, 2022
A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and ...
Ricardo A Cordova, Jagannath Misra, Parth H Amin, Anglea J Klunk, Nur P Damayanti, Kenneth R Carlson, Andrew J Elmendorf, Hyeong-Geug Kim, Emily T Mirek, Bennet D Elzey, Marcus J Miller, X Charlie Dong, Liang Cheng, Tracy G Anthony, Roberto Pili, Ronald C Wek, Kirk A Staschke   +16 more
doaj   +1 more source

GCN2 has inhibitory effect on human immunodeficiency virus-1 protein synthesis and is cleaved upon viral infection. [PDF]

PLoS ONE, 2012
The reversible phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2alpha) is a well-characterized mechanism of translational control in response to a wide variety of cellular stresses, including viral infection. Beside
Javier del Pino, José Luis Jiménez, Iván Ventoso, Alfredo Castelló, Ma Ángeles Muñoz-Fernández, César de Haro, Juan José Berlanga   +6 more
doaj   +1 more source

Overexpression of GCN2-type protein kinase in wheat has profound effects on free amino acid concentration and gene expression [PDF]

, 2011
A key point of regulation of protein synthesis and amino acid homoeostasis in eukaryotes is the phosphorylation of the a subunit of eukaryotic translation initiation factor 2 (eIF2a) by protein kinase general control nonderepressible (GCN)-2.
Wingler, A., Edward H. Byrne, Stephen Powers, Halford, N. G., Byrne, E. H., Powers, S. J., Ian Prosser, Astrid Wingler, Tanya Y. Curtis, Prosser, I. M., Curtis, T. Y., Nigel G. Halford, Muttucumaru, N., Nira Muttucumaru   +13 more
core   +1 more source

Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice

Biomedicines, 2023
GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor survival and progression.
Eric T. Alexander, Erin Fahey, Otto Phanstiel, Susan K. Gilmour   +3 more
doaj   +1 more source

PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells

OncoImmunology, 2018
The immunogenic cell death (ICD) process represents a novel therapeutic approach to treat tumours, in which cytotoxic compounds promote both cancer cell death and the emission of damage-associated molecular patterns (DAMPs) from dying cells, to activate ...
Paola Giglio, Mara Gagliardi, Nicola Tumino, Fernanda Antunes, Soraya Smaili, Diego Cotella, Claudio Santoro, Roberta Bernardini, Maurizio Mattei, Mauro Piacentini, Marco Corazzari   +10 more
doaj   +1 more source

Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells. [PDF]

PLoS Genetics, 2014
The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α, from yeast to mammals.
Sebastien Lageix, Stefan Rothenburg, Thomas E Dever, Alan G Hinnebusch   +3 more
doaj   +1 more source