Results 31 to 40 of about 7,295 (170)

The Metabolic Sensor GCN2 Branches out [PDF]

Cell Metabolism, 2007
GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid deprivation.
openaire   +2 more sources

Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells. [PDF]

PLoS Genetics, 2014
The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α, from yeast to mammals.
Sebastien Lageix, Stefan Rothenburg, Thomas E Dever, Alan G Hinnebusch   +3 more
doaj   +1 more source

Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2

Cancer Research Communications, 2023
Abstract The effect of targeted therapeutics on anticancer immune responses is poorly understood. The BRAF inhibitor dabrafenib has been reported to activate the integrated stress response (ISR) kinase GCN2, and the therapeutic effect has been partially attributed to GCN2 activation.
M. Teresa Ciudad, Rene Quevedo, Sara Lamorte, Robbie Jin, Nadine Nzirorera, Marianne Koritzinsky, Tracy L. McGaha   +6 more
openaire   +3 more sources

The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation

eLife, 2023
Circadian clocks are evolved to adapt to the daily environmental changes under different conditions. The ability to maintain circadian clock functions in response to various stresses and perturbations is important for organismal fitness.
Xiao-Lan Liu, Yulin Yang, Yue Hu, Jingjing Wu, Chuqiao Han, Qiaojia Lu, Xihui Gan, Shaohua Qi, Jinhu Guo, Qun He, Yi Liu, Xiao Liu   +11 more
doaj   +1 more source

Triazolo[4,5-d]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells

Computational and Structural Biotechnology Journal, 2018
Cellular stress signals activate adaptive signaling pathways of the mammalian integrated stress response (ISR), of which the unfolded protein response (UPR) is a subset. These pathways converge at the phosporylation of eIF2α.
Lea Lough, Dan Sherman, Manuel Becerra-Flores, Deepika Vasudevan, Olga Lavinda, Eric Ni, Hong Wang, Hyung Don Ryoo, Raoul Tibes, Timothy Cardozo   +9 more
doaj   +1 more source

Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions

Journal of Genetic Engineering and Biotechnology, 2020
Background Eukaryotic initiation factor 2B (eIF2B) initiates and regulates translation initiation in eukaryotes. eIF2B gene mutations cause leukoencephalopathy called vanishing white matter disease (VWM) in humans and slow growth (Slg−) and general ...
Sonum Sharma, Anuradha Sourirajan, David J. Baumler, Kamal Dev   +3 more
doaj   +1 more source

IDO-GCN2 and autophagy in inflammation

Oncotarget, 2015
Inflammation is a disruptive force in the tissue microenvironment driving extracellular matrix reorganization, production of noxious effector molecules (superoxide, nitric oxide, peroxynitrite, ect.), hypoxia, and active consumption of nutrients required for biosynthesis including amino acids.
openaire   +2 more sources

Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly

Advanced Science, EarlyView.
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang, Xin Wang, Yilan Teng, Zhicheng Wu, Jing Fan, Hongwen Zhu, Peng Dai   +6 more
wiley   +1 more source

Light-Dependent Activation of the GCN2 Kinase Under Cold and Salt Stress Is Mediated by the Photosynthetic Status of the Chloroplast

Frontiers in Plant Science, 2020
Regulation of cytosolic mRNA translation is a key node for rapid adaptation to environmental stress conditions. In yeast and animals, phosphorylation of the α-subunit of eukaryotic translation initiation factor eIF2 is the most thoroughly characterized ...
Ansul Lokdarshi, Philip W. Morgan, Michelle Franks, Zoe Emert, Catherine Emanuel, Albrecht G. von Arnim, Albrecht G. von Arnim   +6 more
doaj   +1 more source

GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

Autophagy Reports, 2022
The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin, Laurent Parry, Wafa B’chir, Valérie Carraro, Cécile Coudy-Gandilhon, Ghita Chaouki, Cédric Chaveroux, Sylvie Mordier, Brigitte Martinie, Vanessa Reinhardt, Céline Jousse, Alain Bruhat, Patrice Codogno, Julien Averous, Pierre Fafournoux   +14 more
doaj   +1 more source