Results 31 to 40 of about 6,913 (153)

PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells

OncoImmunology, 2018
The immunogenic cell death (ICD) process represents a novel therapeutic approach to treat tumours, in which cytotoxic compounds promote both cancer cell death and the emission of damage-associated molecular patterns (DAMPs) from dying cells, to activate ...
Paola Giglio, Mara Gagliardi, Nicola Tumino, Fernanda Antunes, Soraya Smaili, Diego Cotella, Claudio Santoro, Roberta Bernardini, Maurizio Mattei, Mauro Piacentini, Marco Corazzari   +10 more
doaj   +1 more source

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid‐starved cells [PDF]

The EMBO Journal, 2000
GCN2 stimulates GCN4 translation in amino acid-starved cells by phosphorylating the alpha-subunit of translation initiation factor 2. GCN2 function in vivo requires the GCN1/GCN20 complex, which binds to the N-terminal domain of GCN2. A C-terminal segment of GCN1 (residues 2052-2428) was found to be necessary and sufficient for binding GCN2 in vivo and
E, Sattlegger, A G, Hinnebusch
openaire   +2 more sources

GCN2 regulates paclitaxel-induced neuropathic pain. [PDF]

Br J Pharmacol
Background and Purpose Neuropathic pain is debilitating and pervasive. Chemotherapeutic agents commonly induce chronic neuropathic pain. Paclitaxel is a prototypical example, causing painful peripheral neuropathy in a majority of patients.
Mikesell AR, Meyer AR, García G, Frietze LR, Stucky CL, Pan T, Campbell ZT.   +6 more
europepmc   +4 more sources

Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis [PDF]

BMC Plant Biology, 2015
The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified.In this study, we ...
Faus, Isabel, Zabalza Aznárez, Ana, Santiago, Julia, Nebauer, Sergio G., Royuela Hernando, Mercedes, Serrano, Ramón, Gadea, José   +6 more
openaire   +6 more sources

The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation

eLife, 2023
Circadian clocks are evolved to adapt to the daily environmental changes under different conditions. The ability to maintain circadian clock functions in response to various stresses and perturbations is important for organismal fitness.
Xiao-Lan Liu, Yulin Yang, Yue Hu, Jingjing Wu, Chuqiao Han, Qiaojia Lu, Xihui Gan, Shaohua Qi, Jinhu Guo, Qun He, Yi Liu, Xiao Liu   +11 more
doaj   +1 more source

IDO-GCN2 and autophagy in inflammation

Oncotarget, 2015
Inflammation is a disruptive force in the tissue microenvironment driving extracellular matrix reorganization, production of noxious effector molecules (superoxide, nitric oxide, peroxynitrite, ect.), hypoxia, and active consumption of nutrients required for biosynthesis including amino acids.
openaire   +2 more sources

IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans [PDF]

BMC Biology, 2016
The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. As such, GCN2 is required for longevity and stress resistance induced by dietary restriction (DR).
Ferraz, Rafael C., Camara, Henrique, De-Souza, Evandro A., Pinto, Silas, Pinca, Ana Paula F., Silva, Richard C., Sato, Vitor N., Castilho, Beatriz A., Mori, Marcelo A.   +8 more
openaire   +2 more sources

Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions

Journal of Genetic Engineering and Biotechnology, 2020
Background Eukaryotic initiation factor 2B (eIF2B) initiates and regulates translation initiation in eukaryotes. eIF2B gene mutations cause leukoencephalopathy called vanishing white matter disease (VWM) in humans and slow growth (Slg−) and general ...
Sonum Sharma, Anuradha Sourirajan, David J. Baumler, Kamal Dev   +3 more
doaj   +1 more source

Triazolo[4,5-d]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells

Computational and Structural Biotechnology Journal, 2018
Cellular stress signals activate adaptive signaling pathways of the mammalian integrated stress response (ISR), of which the unfolded protein response (UPR) is a subset. These pathways converge at the phosporylation of eIF2α.
Lea Lough, Dan Sherman, Manuel Becerra-Flores, Deepika Vasudevan, Olga Lavinda, Eric Ni, Hong Wang, Hyung Don Ryoo, Raoul Tibes, Timothy Cardozo   +9 more
doaj   +1 more source

Light-Dependent Activation of the GCN2 Kinase Under Cold and Salt Stress Is Mediated by the Photosynthetic Status of the Chloroplast

Frontiers in Plant Science, 2020
Regulation of cytosolic mRNA translation is a key node for rapid adaptation to environmental stress conditions. In yeast and animals, phosphorylation of the α-subunit of eukaryotic translation initiation factor eIF2 is the most thoroughly characterized ...
Ansul Lokdarshi, Philip W. Morgan, Michelle Franks, Zoe Emert, Catherine Emanuel, Albrecht G. von Arnim, Albrecht G. von Arnim   +6 more
doaj   +1 more source