Results 11 to 20 of about 8,559 (195)
Activation of Gcn2 in response to different stresses.
PLoS ONE, 2017 All organisms have evolved pathways to respond to different forms of cellular stress. The Gcn2 kinase is best known as a regulator of translation initiation in response to starvation for amino acids.
Silje Anda +2 more
doaj +4 more sources
GCN2:roles in tumour development and progression [PDF]
Biochemical Society Transactions, 2022 GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress.
Masson, Glenn R. +2 more
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Towards a model of GCN2 activation [PDF]
Biochemical Society Transactions, 2019 Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated Stress Response (ISR), a short-lived pathway that allows cells to either regain cellular ...
Masson, Glenn R.; id_orcid
core +4 more sources
Association of GCN1–GCN20 regulatory complex with the N-terminus of eIF2α kinase GCN2 is required for GCN2 activation [PDF]
The EMBO Journal, 2013 Stimulation of GCN4 mRNA translation due to phosphorylation of the α-subunit of initiation factor 2 (eIF2) by its specific kinase, GCN2, requires binding of uncharged tRNA to a histidyl-tRNA synthetase (HisRS)-like domain in GCN2.
García-Barrio, Minerva, Ufano, Sandra
core +4 more sources
The Metabolic Sensor GCN2 Branches out [PDF]
Cell Metabolism, 2007 GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins.
Towle, Howard C.
core +4 more sources
Involvement of the eIF2α Kinase GCN2 in UV-B Responses [PDF]
Frontiers in Plant Science, 2019 GCN2 (general control nonrepressed 2) is a serine/threonine-protein kinase that regulates translation in response to stressors such as amino acid and purin deprivation, cold shock, wounding, cadmium, and UV-C exposure. Activated GCN2 phosphorylates the α-
Paula Llabata +9 more
doaj +4 more sources
A GCN1-independent activator of the kinase GCN2
Mutations of EIF2AK4, which encodes the eIF2α kinase GCN2, cause a severe inherited form of pulmonary hypertension called pulmonary veno-occlusive disease (PVOD).
Peiqiao Cai +18 more
core +4 more sources
Downhill running regulates cardiac immune response through GCN2.
PLoS ONEDownhill running (DR) has recently emerged as a promising exercise modality for cardiac rehabilitation, but the effect and mechanism of DR on myocardium remains unclear. General control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α (eIF2α)
Xinyue Bai +3 more
doaj +2 more sources
PLoS ONE, 2013 Emerging evidence suggests that dysregulated translation through phosphorylation of eukaryotic initiation factor-2α (eIF2α) may contribute to Alzheimer's disease (AD) and related memory impairments. However, the underlying mechanisms remain unclear. Here,
Latha Devi, Masuo Ohno
doaj +2 more sources
Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis [PDF]
BMC Plant Biology, 2015 Incluye 7 ficheros de datosBackground: The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture.
Serrano, R. +22 more
core +8 more sources