Results 11 to 20 of about 6,913 (153)
Activation of Gcn2 in response to different stresses.
PLoS ONE, 2017 All organisms have evolved pathways to respond to different forms of cellular stress. The Gcn2 kinase is best known as a regulator of translation initiation in response to starvation for amino acids.
Silje Anda +2 more
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Involvement of the eIF2α Kinase GCN2 in UV-B Responses [PDF]
Frontiers in Plant Science, 2019 GCN2 (general control nonrepressed 2) is a serine/threonine-protein kinase that regulates translation in response to stressors such as amino acid and purin deprivation, cold shock, wounding, cadmium, and UV-C exposure. Activated GCN2 phosphorylates the α-
Paula Llabata +9 more
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Multifaceted role of GCN2 in tumor adaptation and therapeutic targeting
Translational OncologyTumor cells voraciously consume nutrients from their environment to facilitate rapid proliferation, necessitating effective strategies to manage nutrient scarcity during tumor growth and progression.
Can Chen, Yaping Xie, Shenxian Qian
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Crystal structures of GCN2 C-terminal domain: Insight into GCN2 regulation [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 General control non-derepressible 2 kinase (GCN2) is a serine threonine kinase that curtails translation in response to diverse stress stimuli [1]. It is a primary sensor of amino acid starvation and mediates translation repression by phosphorylating eIF2 [2].
Isha Singh +6 more
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GCN2: roles in tumour development and progression
Biochemical Society Transactions, 2022 GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress. Recently, there has been renewed interest in GCN2 as a potential oncotarget, with several studies reporting the development of small molecule inhibitors.
Lyssa T. Gold, Glenn R. Masson
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The Gcn2 Kinase as a Cell Cycle Regulator [PDF]
Cell Cycle, 2007 Cell cycle progression through G1 phase is of particular importance because this is the phase where the decision to embark on another cell cycle is made. An aberrant G1/S transition often leads to cell cycle deregulation and cancer development. Therefore, there is a complex regulatory network to ensure timely entry into S phase, coordinating initiation
Beáta, Grallert, Erik, Boye
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Antioxidants, 2022 It is well recognized that there is a strong and complex association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D).
Juntao Yuan +7 more
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GCN2 Whets the Appetite for Amino Acids [PDF]
Molecular Cell, 2005 In response to amino acid starvation, the kinase GCN2 in yeast activates amino acid biosynthesis. Two recent studies (Maurin et al., 2005; Hao et al., 2005) reveal that GCN2 in the brain of mice restricts intake of diets lacking essential amino acids.
Dever, Thomas E., Hinnebusch, Alan G.
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Activation of the integrated stress response by inhibitors of its kinases
Nature Communications, 2023 Phosphorylation of the translation initiation factor eIF2α to initiate the integrated stress response (ISR) is a vital signalling event. Protein kinases activating the ISR, including PERK and GCN2, have attracted considerable attention for drug ...
Maria Szaruga +7 more
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Association of GCN1–GCN20 regulatory complex with the N‐terminus of eIF2α kinase GCN2 is required for GCN2 activation [PDF]
The EMBO Journal, 2000 Stimulation of GCN4 mRNA translation due to phosphorylation of the alpha-subunit of initiation factor 2 (eIF2) by its specific kinase, GCN2, requires binding of uncharged tRNA to a histidyl-tRNA synthetase (HisRS)-like domain in GCN2. GCN2 function in vivo also requires GCN1 and GCN20, but it was unknown whether these latter proteins act directly to ...
M, Garcia-Barrio +3 more
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