Results 11 to 20 of about 7,295 (170)
Activation of Gcn2 in response to different stresses.
PLoS ONE, 2017 All organisms have evolved pathways to respond to different forms of cellular stress. The Gcn2 kinase is best known as a regulator of translation initiation in response to starvation for amino acids.
Silje Anda +2 more
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Involvement of the eIF2α Kinase GCN2 in UV-B Responses [PDF]
Frontiers in Plant Science, 2019 GCN2 (general control nonrepressed 2) is a serine/threonine-protein kinase that regulates translation in response to stressors such as amino acid and purin deprivation, cold shock, wounding, cadmium, and UV-C exposure. Activated GCN2 phosphorylates the α-
Paula Llabata +9 more
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Yeast Gcn2 retains activity following humanization of its auto-phosphorylation region. [PDF]
FEBS Open BioUsing Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Anderson RA, Schiemann AH, Sattlegger E.
europepmc +2 more sources
Multifaceted role of GCN2 in tumor adaptation and therapeutic targeting
Translational OncologyTumor cells voraciously consume nutrients from their environment to facilitate rapid proliferation, necessitating effective strategies to manage nutrient scarcity during tumor growth and progression.
Can Chen, Yaping Xie, Shenxian Qian
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer. [PDF]
Mol OncolCancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Kim A +7 more
europepmc +2 more sources
Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD [PDF]
Advanced scienceThis study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Liu S +20 more
europepmc +2 more sources
Crystal structures of GCN2 C-terminal domain: Insight into GCN2 regulation [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 General control non-derepressible 2 kinase (GCN2) is a serine threonine kinase that curtails translation in response to diverse stress stimuli [1]. It is a primary sensor of amino acid starvation and mediates translation repression by phosphorylating eIF2 [2].
Isha Singh +6 more
openaire +1 more source
GCN2: roles in tumour development and progression
Biochemical Society Transactions, 2022 GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress. Recently, there has been renewed interest in GCN2 as a potential oncotarget, with several studies reporting the development of small molecule inhibitors.
Lyssa T. Gold, Glenn R. Masson
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Antioxidants, 2022 It is well recognized that there is a strong and complex association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D).
Juntao Yuan +7 more
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The Gcn2 Kinase as a Cell Cycle Regulator [PDF]
Cell Cycle, 2007 Cell cycle progression through G1 phase is of particular importance because this is the phase where the decision to embark on another cell cycle is made. An aberrant G1/S transition often leads to cell cycle deregulation and cancer development. Therefore, there is a complex regulatory network to ensure timely entry into S phase, coordinating initiation
Beáta, Grallert, Erik, Boye
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