Results 21 to 30 of about 7,295 (170)
Activation of the integrated stress response by inhibitors of its kinases
Nature Communications, 2023 Phosphorylation of the translation initiation factor eIF2α to initiate the integrated stress response (ISR) is a vital signalling event. Protein kinases activating the ISR, including PERK and GCN2, have attracted considerable attention for drug ...
Maria Szaruga +7 more
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GCN2 Whets the Appetite for Amino Acids [PDF]
Molecular Cell, 2005 In response to amino acid starvation, the kinase GCN2 in yeast activates amino acid biosynthesis. Two recent studies (Maurin et al., 2005; Hao et al., 2005) reveal that GCN2 in the brain of mice restricts intake of diets lacking essential amino acids.
Dever, Thomas E., Hinnebusch, Alan G.
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GCN2 and TOR converge on aging
Aging, 2013 Coordinated responses in all tissues upon nutrient stress ensure the survival of an organism in periods of food unavailability. Two evolutionarily conserved, nutrient-sensing signaling pathways that promote stress adaptation following starvation are the general amino acid control pathway that activates GCN2 kinase and the target of rapamycin (TOR ...
Vlanti, A., Rousakis, A., Syntichaki, P.
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GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
eLife, 2022 A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and ...
Ricardo A Cordova +16 more
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Towards a model of GCN2 activation [PDF]
Biochemical Society Transactions, 2019 Abstract Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated Stress Response (ISR), a short-lived pathway that allows cells to either regain cellular homeostasis or facilitate apoptosis during periods of stress.
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GCN2 has inhibitory effect on human immunodeficiency virus-1 protein synthesis and is cleaved upon viral infection. [PDF]
PLoS ONE, 2012 The reversible phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2alpha) is a well-characterized mechanism of translational control in response to a wide variety of cellular stresses, including viral infection. Beside
Javier del Pino +6 more
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Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice
Biomedicines, 2023 GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor survival and progression.
Eric T. Alexander +3 more
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Redox Biology, 2018 The clinical use of doxorubicin for cancer therapy is limited by its cardiotoxicity, which involves cardiomyocyte apoptosis and oxidative stress. Previously, we showed that general control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α ...
Yue Wang +7 more
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PLoS ONE, 2013 Emerging evidence suggests that dysregulated translation through phosphorylation of eukaryotic initiation factor-2α (eIF2α) may contribute to Alzheimer's disease (AD) and related memory impairments. However, the underlying mechanisms remain unclear. Here,
Latha Devi, Masuo Ohno
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OncoImmunology, 2018 The immunogenic cell death (ICD) process represents a novel therapeutic approach to treat tumours, in which cytotoxic compounds promote both cancer cell death and the emission of damage-associated molecular patterns (DAMPs) from dying cells, to activate ...
Paola Giglio +10 more
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