Results 21 to 30 of about 8,559 (195)
Redox Biology, 2018 The clinical use of doxorubicin for cancer therapy is limited by its cardiotoxicity, which involves cardiomyocyte apoptosis and oxidative stress. Previously, we showed that general control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α ...
Yue Wang +7 more
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Novel cancer-related roles of GCN2
, 2020 GCN2, an amino-acid deprivation sensor is one of the kinases activated during the integrated stress response. Its role in normal as well as in cancer cells during stress induced by starvation has garnered a lot of attention.
Sharma Humagain, Prabin
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Multifaceted role of GCN2 in tumor adaptation and therapeutic targeting
Translational OncologyTumor cells voraciously consume nutrients from their environment to facilitate rapid proliferation, necessitating effective strategies to manage nutrient scarcity during tumor growth and progression.
Can Chen, Yaping Xie, Shenxian Qian
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An In Vitro System to Study Mammalian GCN2 Regulation
General control non-derepressible 2 (GCN2) is an eIF2α kinase responsible for eliciting the integrated stress response (ISR) under amino acid starvation conditions.
Masson, Glenn R.; id_orcid +1 more
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Activation of Gcn2 by Pharmacological Agents Designed to be Inhibitors [PDF]
, 2023 Indiana University-Purdue University Indianapolis (IUPUI)The integrated stress response (ISR) is an important mechanism by which cells confer protection against environmental stresses.
Carlson, Kenneth Reed
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Interleukin-6 is critical in the development of pulmonary vascular disease in <i>Gcn2-</i>deficient mice. [PDF]
Proc Natl Acad Sci U S ABiallelic mutations in EIF2AK4, encoding Eukaryotic Translation Initiation Factor 2α kinase 4 or General Control Nonderepressible 2 (GCN2), cause pulmonary veno-occlusive disease (PVOD), a fatal form of pulmonary hypertension. The mechanisms linking GCN2
Schwiening M +12 more
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Crystal structures of GCN2 C-terminal domain: Insight into GCN2 regulation [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 General control non-derepressible 2 kinase (GCN2) is a serine threonine kinase that curtails translation in response to diverse stress stimuli [1]. It is a primary sensor of amino acid starvation and mediates translation repression by phosphorylating eIF2 [2].
Isha Singh +6 more
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Frontiers in Aging, 2022 Restriction of amino acids in the diet can extend lifespan in diverse species ranging from flies to mammals. However, the role of individual amino acids and the underlying molecular mechanisms are only partially understood.
Anchal Srivastava +6 more
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Antioxidants, 2022 It is well recognized that there is a strong and complex association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D).
Juntao Yuan +7 more
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The Gcn2 Kinase as a Cell Cycle Regulator [PDF]
Cell Cycle, 2007 Cell cycle progression through G1 phase is of particular importance because this is the phase where the decision to embark on another cell cycle is made. An aberrant G1/S transition often leads to cell cycle deregulation and cancer development. Therefore, there is a complex regulatory network to ensure timely entry into S phase, coordinating initiation
Beáta, Grallert, Erik, Boye
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