Results 21 to 30 of about 6,913 (153)
GCN2 and TOR converge on aging
Aging, 2013 Coordinated responses in all tissues upon nutrient stress ensure the survival of an organism in periods of food unavailability. Two evolutionarily conserved, nutrient-sensing signaling pathways that promote stress adaptation following starvation are the general amino acid control pathway that activates GCN2 kinase and the target of rapamycin (TOR ...
Vlanti, A., Rousakis, A., Syntichaki, P.
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GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
eLife, 2022 A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and ...
Ricardo A Cordova +16 more
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Towards a model of GCN2 activation [PDF]
Biochemical Society Transactions, 2019 Abstract Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated Stress Response (ISR), a short-lived pathway that allows cells to either regain cellular homeostasis or facilitate apoptosis during periods of stress.
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Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2
Cancer Research Communications, 2023 Abstract The effect of targeted therapeutics on anticancer immune responses is poorly understood. The BRAF inhibitor dabrafenib has been reported to activate the integrated stress response (ISR) kinase GCN2, and the therapeutic effect has been partially attributed to GCN2 activation.
M. Teresa Ciudad +6 more
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GCN2 has inhibitory effect on human immunodeficiency virus-1 protein synthesis and is cleaved upon viral infection. [PDF]
PLoS ONE, 2012 The reversible phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2alpha) is a well-characterized mechanism of translational control in response to a wide variety of cellular stresses, including viral infection. Beside
Javier del Pino +6 more
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Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice
Biomedicines, 2023 GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor survival and progression.
Eric T. Alexander +3 more
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Redox Biology, 2018 The clinical use of doxorubicin for cancer therapy is limited by its cardiotoxicity, which involves cardiomyocyte apoptosis and oxidative stress. Previously, we showed that general control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α ...
Yue Wang +7 more
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The Metabolic Sensor GCN2 Branches out [PDF]
Cell Metabolism, 2007 GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid deprivation.
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PLoS ONE, 2013 Emerging evidence suggests that dysregulated translation through phosphorylation of eukaryotic initiation factor-2α (eIF2α) may contribute to Alzheimer's disease (AD) and related memory impairments. However, the underlying mechanisms remain unclear. Here,
Latha Devi, Masuo Ohno
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Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells. [PDF]
PLoS Genetics, 2014 The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α, from yeast to mammals.
Sebastien Lageix +3 more
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