Novel cancer-related roles of GCN2
, 2020 GCN2, an amino-acid deprivation sensor is one of the kinases activated during the integrated stress response. Its role in normal as well as in cancer cells during stress induced by starvation has garnered a lot of attention. Most of the literature describes GCN2’s role based on its action on the eIF2-ATF4 pathway.
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GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
Cell ReportsSummary: Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity.
Alexandros P. Drainas +9 more
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Role of mTORC1 and GCN2 signaling in immune cells [PDF]
SCIENTIA SINICA Vitae, 2022 YuYi YE +3 more
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Redox-metabolic circuits as a central regulator of T cell-based immunotherapy. [PDF]
Front ImmunolMcPhedran S, Zhao T, Lum JJ.
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An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity. [PDF]
J Biol ChemMisra J +5 more
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Extracellular vesicles derived by hypoxic preconditioned EPCs attenuated atherosclerosis by suppressing ferroptosis via regulating arginine metabolism. [PDF]
Redox BiolLuo X +18 more
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Amino acid insufficiency orchestrates AMPK and mTOR signaling. [PDF]
Fundam ResLi T, Zhao L, Jia D.
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A Novel Potent and Selective GCN2 Inhibitor, APL-4098, Has Antileukemic Activity through Dysregulation of Mitochondrial Function. [PDF]
Clin Cancer ResRomán-Trufero M +9 more
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Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly. [PDF]
Proc Natl Acad Sci U S AGötz MS +4 more
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