Results 51 to 60 of about 36,093 (252)

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins [PDF]

Nature Cell Biology, 2011
How individual cells respond to mechanical forces is of considerable interest to biologists as force affects many aspects of cell behavior1. Application of force on integrins triggers cytoskeletal rearrangements and growth of the associated adhesion complex, resulting in increased cellular stiffness2,3, also known as reinforcement4. While RhoA has been
Guilluy, Christophe, Swaminathan, Vinay, Garcia-Mata, Rafael, O’Brien, E. Timothy, Superfine, Richard, Burridge, Keith   +5 more
openaire   +2 more sources

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF

Oncotarget, 2016
Cell migration is a process crucial for a variety of biological events, such as morphogenesis and wound healing. Several reports have described the possible regulation of cell migration by autophagy; however, this remains controversial. We here demonstrate that mouse embryonic fibroblasts (MEFs) lacking autophagy protein 5 (Atg5), an essential molecule
Yoshida, Tatsushi, Tsujioka, Masatsune, Honda, Shinya, Tanaka, Masato, Shimizu, Shigeomi   +4 more
openaire   +2 more sources

SOS GEFs in health and disease

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020
SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins contain a sequence of modular domains that are responsible for different intramolecular and intermolecular interactions modulating mechanisms of self-inhibition, allosteric ...
Baltanás, Fernando C, Zarich-Dimitrievich, Natasha, Rojas-Cabañeros, Jose Maria, Santos, Eugenio   +3 more
openaire   +6 more sources

GEFs: Dual regulation of Rac1 signaling [PDF]

Small GTPases, 2016
GEFs play a critical role in regulating Rac1 signaling. They serve as signaling nodes converting upstream signals into downstream Rac1-driven cellular responses. Through associating with membrane-bound Rac1, GEFs facilitate the exchange of GDP for GTP, thereby activating Rac1.
Hadir Marei1, Malliri, Angeliki; id_orcid 0000-0001-6848-090X   +1 more
openaire   +2 more sources

Franquia: Inovação em franquias de serviços sociais: Iniciativa público privada | Adm. Sidney L. Vitorino | Blog GEF

, 2018
Artigo técnico profissional realizado pelo Coord. Adm. Sidney Lincoln Vitorino, MSc do Grupo de Excelência em Franquias - GEF, para o Blog do GEF.Publicação do Blog: https://gefemacao.wixsite.com/gefemacao - 24/02 ...
GEF Grupo de Excelência em Franquias | CRA-SP (5844560), Sidney Lincoln Vitorino (5707031)   +1 more
core   +1 more source

Microplastics in the menu of Mediterranean zooplankton: Insights from the feeding response of the calanoid copepod Centropages typicus

Marine Ecology, EarlyView., 2023
Abstract Microplastic input into the ocean represents an increasing threat to marine biota and may endanger the functioning of marine ecosystems, especially in semi‐enclosed basins, such as the Mediterranean Sea. The size spectrum of microplastics overlaps with that of nano‐microplankton (2–200 μm), thus potentially misleading suspension‐feeding ...
Claudia Traboni, Diana Sarno, Maurizio Ribera d'Alcalà, Maria Grazia Mazzocchi   +3 more
wiley   +1 more source

PROGRAM OF TUTOR SUPPORT OF FORMATION ICT COMPETENCE OF TEACHERS AS A NEW EDUCATIONAL PRODUCT

Вестник Мининского университета, 2017
In the formation of the ICT competence of teachers important role is given to tutor support. The tutor, performing support of process of improvement teacher qualifications on the basis of an educational institution, provides the implementation of the ...
O. F. Bryksina, T. I. Kanyanina, E. P. Krupoderova   +2 more
doaj   +2 more sources

Naringin alleviates gefitinib-induced hepatotoxicity through anti-oxidation, inhibition of apoptosis, and autophagy [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Gefitinib (GEF) is a targeted medicine used to treat locally advanced or metastatic non-small cell lung cancer (NSCLC). However, GEF’s hepatotoxicity limits its clinical use. This study aims to investigate the protective effect of naringin (
Dan Liu, Changlin Zhen, Xiuzhen He, wansong chen, Juan Pan, Mengying Yin, Mengru Zhong, Hongyan Zhang, Xiaohuan Huang, Yonghui Zhang   +9 more
doaj   +1 more source

Governing Artificial Intelligence and Digital Economy for Sustainability: Does Institutional Quality Help or Hinder SDGs Progress Across OECD Countries?

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates how artificial intelligence (AI) can support sustainable development strategies in OECD countries, particularly in achieving the United Nations Sustainable Development Goals (SDGs). The study contributes to the literature by investigating the role of AI as a transformative enabler of sustainable business strategies ...
Muskan Sahu, Waleed M. Alahdal, Mohammed M. Elgammal   +2 more
wiley   +1 more source

Dissolution enhancement of Gefitinib by solid dispersion and complexation with β-cyclodextrins: In vitro testing, cytotoxic activity, and tablet formulation

Saudi Pharmaceutical Journal
Cancer is the leading cause of mortality worldwide. In patients with metastatic non-small cell lung cancer, epidermal growth factor receptor (EGFR) is often overexpressed.
Adel F. Alghaith, Gamal M. Mahrous, Ahmed S. Alenazi, Suliaman M. ALMufarrij, Mohammed S. Alhazzaa, Awwad A. Radwan, Abdullah S. Alhamed, Mohamed S. Bin Salamah, Sultan Alshehri   +8 more
doaj   +1 more source