Results 181 to 190 of about 17,212 (306)

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

open access: yesBrain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová   +19 more
wiley   +1 more source

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin   +7 more
wiley   +1 more source

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

open access: yesCell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu   +7 more
wiley   +1 more source

Functional Properties of <i>Brosimum alicastrum</i> Seed Flour Gels: Impact of Temperature, Concentration, and Additives on Rheology, Viscoelasticity, and Texture. [PDF]

open access: yesInt J Mol Sci
Cabrera-Ramírez ÁH   +6 more
europepmc   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

open access: yesCell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang   +12 more
wiley   +1 more source

Predator cues from jumping spiders modulate herbivore behaviour and reduce plant damage

open access: yesEcological Entomology, EarlyView.
Jumping spider cues increase immobility and delay first reproduction in the aphid Myzus persicae. Spider cues reduce leaf consumption by chewing herbivores, indicating reduced herbivore pressure on plants. Jumping spider cues may mediate indirect effects across trophic levels by altering herbivore behaviour and plant–herbivore interactions.
Paloma Ceribelli   +2 more
wiley   +1 more source

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