Results 201 to 210 of about 8,013,600 (393)

Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient‐derived xenograft models

Molecular Oncology, Volume 19, Issue 4, Page 1075-1091, April 2025.
Pancreatic ductal adenocarcinoma patient‐derived xenografts (PDAC‐PDXs) engrafted orthotopically in the pancreas of immunodeficient mice retain the main genetic and histopathological characteristics of the original human tumors. A 294 stroma gene signature differentiates between PDAC‐PDXs that are responsive to gemcitabine plus nab‐paclitaxel versus ...
Alessia Anastasia, Laura Formenti, Paola Ostano, Lucia Minoli, Andrea Resovi, Lavinia Morosi, Claudia Fioravanti, Edoardo Micotti, Cristina Matteo, Eugenio Scanziani, Giovanna Chiorino, Raffaella Giavazzi, Carmen Ghilardi, Dorina Belotti   +13 more
wiley   +1 more source

Electrochemical Gene Amplification Signal Detection of Disposable Biochips Using Electrodes. [PDF]

Sensors (Basel), 2022
Kim GR, Hwang JS, Kim JD, Kim YS, Park CY.   +4 more
europepmc   +1 more source

Gene amplification: an example of accelerated evolution in tumorigenic cells. [PDF]

, 1985
Ruth Sager, Inder Gadi, Len Stephens, Constance T. Grabowy   +3 more
openalex   +1 more source

Gene Amplification

Definitions, 2019

semanticscholar   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

SARS-CoV-2 and Swabs: Disease Severity and the Numbers of Cycles of Gene Amplification, Single Center Experience. [PDF]

Children (Basel), 2023
Falsaperla R, Sortino V, Collotta AD, Marino S, Pavone P, Grassi L, Privitera GF, Ruggieri M.   +7 more
europepmc   +1 more source

A subset of herpes simplex virus replication genes induces DNA amplification within the host cell genome [PDF]

, 1989
Regine Heilbronn, Harald zur Hausen
openalex   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

ZNF217 Gene Copy Number as a Marker of Response to Standard Therapy Drugs According to ERα Status in Breast Cancer

Breast Cancer: Targets and Therapy
Nelson Rangel,1 Iris Lorena Sánchez,2 Duván Sebastián Valbuena,2 Milena Rondón-Lagos2 1Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, 110231, Colombia; 2School of Biological Sciences, Universidad ...
Rangel N, Sánchez IL, Valbuena DS, Rondón-Lagos M   +3 more
doaj  

Amplified ribosomal RNA genes in a rat hepatoma cell line are enriched in 5-methylcytosine.

, 1981
Umadevi Tantravahi, R V Guntaka, Bernard F. Erlanger, O.J. Miller   +3 more
openalex   +1 more source