Results 51 to 60 of about 8,013,600 (393)
Massive gene amplification on a recently formed Drosophila Y chromosome. [PDF]
, 2019 Widespread loss of genes on the Y is considered a hallmark of sex chromosome differentiation. Here we show that the initial stages of Y evolution are driven by massive amplification of distinct classes of genes. The neo-Y chromosome of Drosophila miranda
Bachtrog, Doris +2 more
core +1 more source
Molecular Cytogenetics, 2011 Background The goal of this study was to investigate ERBB2(HER2) and EGFR gene amplification and protein expression in gastric cancer. Fluorescence in situ hybridization (FISH) and immunohistochemistry were used to analyze ERBB2 and EGFR gene ...
XX Lv +7 more
doaj +1 more source
Oncogene, 2015 The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small.
C. Anadón +16 more
semanticscholar +1 more source
Gene amplification system based on double rolling-circle replication as a model for oncogene-type amplification [PDF]
, 2011 Gene amplification contributes to a variety of biological phenomena, including malignant progression and drug resistance. However, details of the molecular mechanisms remain to be determined.
HORIUCHI Takashi +2 more
core +2 more sources
Activating HER2 mutations in HER2 gene amplification negative breast cancer.
Cancer Discovery, 2013 UNLABELLED Data from 8 breast cancer genome-sequencing projects identified 25 patients with HER2 somatic mutations in cancers lacking HER2 gene amplification.
R. Bose +13 more
semanticscholar +1 more source
Evolution of Gene Expression after Gene Amplification [PDF]
Genome Biology and Evolution, 2015 We took a rather unique approach to investigate the conservation of gene expression of prolamin storage protein genes across two different subfamilies of the Poaceae. We took advantage of oat plants carrying single maize chromosomes in different cultivars, called oat-maize addition (OMA) lines, which permitted us to determine whether regulation of gene
Joachim Messing +3 more
openaire +3 more sources
PLoS ONE, 2014 This study aimed at determining the incidence and clinical implications of HER2 status in primary colorectal cancer (CRC). HER2 status was investigated in two retrospective cohorts of 365 consecutive CRC patients (cohort 1) and 174 advanced CRC patients ...
A. Seo +6 more
semanticscholar +1 more source
Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe [PDF]
, 1993 A modification of reverse chromosome painting was carried out using genomic DNA from tumor cells as a complex probe for chromosomal in situ suppression hybridization to normal metaphase chromsome spreads.
Cremer, Thomas +5 more
core +1 more source
Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2003 Signaling by the transforming growth factor (TGF)family members is transduced from the cell surface to the nucleus by the Smad group of intracellular proteins. Because we detected alterations on the long arm of chromosome 5, we examined the status of the
Drazen B. Zimonjic +5 more
doaj +1 more source