Results 51 to 60 of about 7,371,567 (249)

Mutations and amplification of oncogenes in endometrial cancer [PDF]

, 1999
Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
An, Han-Xiang, Beckmann, Matthias W., Bender, Hans G., Cho, Yong-Jig, Hantschmann, Peer, Niederacher, Dieter   +5 more
core   +1 more source

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

Oncogene, 2015
The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small.
C. Anadón, S. Guil, L. Simó-Riudalbas, C. Moutinho, F. Setién, A. Martínez-Cardús, S. Moran, A. Villanueva, M. Calaf, A. Vidal, P. Lazo, I. Zondervan, S. Savola, T. Kohno, J. Yokota, L. R. de Pouplana, M. Esteller   +16 more
semanticscholar   +1 more source

Activating HER2 mutations in HER2 gene amplification negative breast cancer.

Cancer Discovery, 2013
UNLABELLED Data from 8 breast cancer genome-sequencing projects identified 25 patients with HER2 somatic mutations in cancers lacking HER2 gene amplification.
R. Bose, Shyam M. Kavuri, Adam C. Searleman, W. Shen, D. Shen, D. Koboldt, J. Monsey, Nicholas J. Goel, Adam B Aronson, Shunqiang Li, Cynthia X. Ma, L. Ding, E. Mardis, M. Ellis   +13 more
semanticscholar   +1 more source

Correlation Between C-MYC, BCL-2, and BCL-6 Protein Expression and Gene Translocation as Biomarkers in Diagnosis and Prognosis of Diffuse Large B-cell Lymphoma

Frontiers in Pharmacology, 2019
This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities.
YunXiang Zhang, Hui Wang, Cuiai Ren, Hai Yu, Wenjia Fang, Na Zhang, Sumei Gao, Qian Hou   +7 more
doaj   +1 more source

Fibroblast Growth Factor Receptor 3 (FGFR3) Gene Amplification in Patients with Urothelial Carcinoma of the Urinary Bladder

The Iraqi Journal of Medical Sciences, 2021
Background: The fibroblast growth factor receptors (FGFRs) family includes five tyrosine kinase receptors, which play an important role in many cellular mechanisms including proliferation, migration and survival.
Mohsin Al-Marashi, Ban Qasim
doaj   +1 more source

Evolution of Gene Expression after Gene Amplification [PDF]

Genome Biology and Evolution, 2015
We took a rather unique approach to investigate the conservation of gene expression of prolamin storage protein genes across two different subfamilies of the Poaceae. We took advantage of oat plants carrying single maize chromosomes in different cultivars, called oat-maize addition (OMA) lines, which permitted us to determine whether regulation of gene
Joachim Messing, Yongrui Wu, Wei Zhang, Nelson Garcia   +3 more
openaire   +3 more sources

Amplification of the Chromosomal blaCTX-M-14 Gene in Escherichia coli Expanding the Spectrum of Resistance under Antimicrobial Pressure

Microbiology Spectrum, 2022
Various forms of adaptive evolution occur in clinical isolates in response to the presence of antimicrobial drugs. Among a total of 171 CTX-M-9 group/family extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli blood isolates recovered ...
Eun-Jeong Yoon, You Jeong Choi, Dokyun Kim, Dongju Won, Jong Rak Choi, Seok Hoon Jeong   +5 more
doaj   +1 more source

HER2 Status in Colorectal Cancer: Its Clinical Significance and the Relationship between HER2 Gene Amplification and Expression

PLoS ONE, 2014
This study aimed at determining the incidence and clinical implications of HER2 status in primary colorectal cancer (CRC). HER2 status was investigated in two retrospective cohorts of 365 consecutive CRC patients (cohort 1) and 174 advanced CRC patients ...
A. Seo, Y. Kwak, Duck-Woo Kim, Sung-Bum Kang, G. Choe, W. Kim, H. Lee   +6 more
semanticscholar   +1 more source

The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis

Archives of Medical Science, 2019
Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and
Jian-Long Miao, Jin-Hua Zhou, Jing-Jing Cai, Rui-Juan Liu   +3 more
doaj   +1 more source

Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer [PDF]

, 2015
Introduction Aromatase inhibitors (AIs) are a vital component of estrogen receptor positive (ER+) breast cancer treatment. De novo and acquired resistance, however, is common.
A Mackay, AK Dunbier, AK Dunbier, Alan Mackay, Alexey Larionov, Anita K Dunbier, Aradhana Rani, Ash Nerurkar, B Weigelt, BP Coe, C Curtis, C Kent, D Generali, DG Albertson, DS Tan, Elena López-Knowles, F Kreisel, Helen Anderson, HW Cheung, IE Smith, IE Smith, J Hicks, J Michael Dixon, Jorge S Reis-Filho, JS Foster, K Lundgren, L Osterberg, LA Martin, LA Martin, LA Martin, Lesley-Ann Martin, LG Leon, Lorna Renshaw, M Dowsett, M Mello-Grand, M Scaltriti, Mitch Dowsett, MJ Ellis, MT Weigel, N Turner, P Darbre, P Lal, Paul M Wilkerson, Peter Osin, PM Wilkerson, PM Wilkerson, PT Simpson, R Beroukhim, R Duprez, R Katz-Brull, R Natrajan, R Natrajan, R Natrajan, Ricardo Ribas, T Miyake, T Troiani, TK Lam, William R Miller, WR Miller, WR Miller, WR Miller, WR Miller, X Huo, Y Zhao, Z Ghazoui, Zara Ghazoui   +65 more
core   +3 more sources