Results 11 to 20 of about 401,494 (259)

A gene wiki for community annotation of gene function. [PDF]

PLoS Biology, 2008
This manuscript describes the creation of comprehensive gene wiki, seeded with data from public domain sources, which will enable and encourage community annotation of gene function.
Jon W Huss, Camilo Orozco, James Goodale, Chunlei Wu, Serge Batalov, Tim J Vickers, Faramarz Valafar, Andrew I Su   +7 more
doaj   +6 more sources

Gene characterization index: assessing the depth of gene annotation.

PLoS ONE, 2008
BackgroundWe introduce the Gene Characterization Index, a bioinformatics method for scoring the extent to which a protein-encoding gene is functionally described. Inherently a reflection of human perception, the Gene Characterization Index is applied for
Danielle Kemmer, Raf M Podowski, Dimas Yusuf, Jochen Brumm, Warren Cheung, Claes Wahlestedt, Boris Lenhard, Wyeth W Wasserman   +7 more
doaj   +5 more sources

Impact of gene annotation choice on the quantification of RNA-seq data [PDF]

BMC Bioinformatics, 2022
Background RNA sequencing is currently the method of choice for genome-wide profiling of gene expression. A popular approach to quantify expression levels of genes from RNA-seq data is to map reads to a reference genome and then count mapped reads to ...
David Chisanga, Yang Liao, Wei Shi
doaj   +2 more sources

The use of semantic similarity measures for optimally integrating heterogeneous Gene Ontology data from large scale annotation pipelines

Frontiers in Genetics, 2014
With the advancement of new high throughput sequencing technologies, there has been an increase in the number of genome sequencing projects worldwide, which has yielded complete genome sequences of human, animals and plants.
Gaston K Mazandu, Nicola eMulder
doaj   +3 more sources

GENCODE 2025: reference gene annotation for human and mouse [PDF]

Nucleic Acids Research
Ewan Birney, Robert D Finn, Benedict Paten   +2 more
exaly   +2 more sources

Consistent annotation of gene expression arrays [PDF]

BMC Genomics, 2010
Background Gene expression arrays are valuable and widely used tools for biomedical research. Today's commercial arrays attempt to measure the expression level of all of the genes in the genome.
Proctor Glenn, Johnson Nathan, Ballester Benoît, Flicek Paul   +3 more
doaj   +4 more sources

Student biocuration projects as a learning environment [version 2; peer review: 2 approved]

F1000Research, 2022
Background: Bioinformatics is becoming an essential tool for the majority of biological and biomedical researchers. Although bioinformatics data is exploited by academic and industrial researchers, limited focus is on teaching this area to undergraduates,
Ruth C. Lovering, Katherine E. Thurlow, Sandra De Miranda Pinheiro   +2 more
doaj   +1 more source

Capturing heart valve development with Gene Ontology

Frontiers in Genetics, 2023
Introduction: The normal development of all heart valves requires highly coordinated signaling pathways and downstream mediators. While genomic variants can be responsible for congenital valve disease, environmental factors can also play a role. Later in
Saadullah H. Ahmed, Alexander T. Deng, Rachael P. Huntley, Nancy H. Campbell, Ruth C. Lovering   +4 more
doaj   +1 more source

GOing Forward With the Cardiac Conduction System Using Gene Ontology

Frontiers in Genetics, 2022
The cardiac conduction system (CCS) comprises critical components responsible for the initiation, propagation, and coordination of the action potential. Aberrant CCS development can cause conduction abnormalities, including sick sinus syndrome, accessory
Kan Yan Chloe Li, Kan Yan Chloe Li, Andrew C Cook, Ruth C Lovering   +3 more
doaj   +1 more source

Insights into Online microRNA Bioinformatics Tools

Non-Coding RNA, 2023
MicroRNAs (miRNAs) are members of the small non-coding RNA family regulating gene expression at the post-transcriptional level. MiRNAs have been found to have critical roles in various biological and pathological processes.
Diana Luna Buitrago, Ruth C. Lovering, Andrea Caporali   +2 more
doaj   +1 more source