Results 31 to 40 of about 10,955,304 (331)
BMC Genomics, 2021 Background Functional genome annotation is the process of labelling functional genomic regions with descriptive information. Manual curation can produce higher quality genome annotations than fully automated methods.
Matthew R. Lueder +6 more
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PINOT: an intuitive resource for integrating protein-protein interactions
Cell Communication and Signaling, 2020 Background The past decade has seen the rise of omics data for the understanding of biological systems in health and disease. This wealth of information includes protein-protein interaction (PPI) data derived from both low- and high-throughput assays ...
James E. Tomkins +7 more
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Liftoff: accurate mapping of gene annotations [PDF]
Bioinformatics, 2021 Abstract Motivation Improvements in DNA sequencing technology and computational methods have led to a substantial increase in the creation of high-quality genome assemblies of many species. To understand the biology of these genomes, annotation of gene features and other functional elements is ...
Alaina Shumate, Steven L. Salzberg
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Community gene annotation in practice [PDF]
Database, 2012 Manual annotation of genomic data is extremely valuable to produce an accurate reference gene set but is expensive compared with automatic methods and so has been limited to model organisms. Annotation tools that have been developed at the Wellcome Trust Sanger Institute (WTSI, http://www.sanger.ac.uk/.) are being used to fill that gap, as they can be ...
Jane E. Loveland +3 more
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Exploiting proteomic data for genome annotation and gene model validation in
, 2009 Background Proteomic data is a potentially rich, but arguably unexploited, data source for genome annotation. Peptide identifications from tandem mass spectrometry provide prima facie evidence for gene predictions and can discriminate over a set of ...
Simon J Gaskell +35 more
core +1 more source
Logical Gene Ontology Annotations (GOAL): exploring gene ontology annotations with OWL [PDF]
Journal of Biomedical Semantics, 2012 Ontologies such as the Gene Ontology (GO) and their use in annotations make cross species comparisons of genes possible, along with a wide range of other analytical activities. The bio-ontologies community, in particular the Open Biomedical Ontologies (OBO) community, have provided many other ontologies and an increasingly large volume of annotations ...
Jupp, Simon +2 more
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Comparison of three microarray probe annotation pipelines: differences in strategies and their effect on downstream analysis [PDF]
, 2009 BACKGROUND: Reliable annotation linking oligonucleotide probes to target genes is essential for functional biological analysis of microarray experiments.
Groenen, M.A. +18 more
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Improving the Annotation of Arabidopsis lyrata Using RNA-Seq Data. [PDF]
PLoS ONE, 2015 Gene model annotations are important community resources that ensure comparability and reproducibility of analyses and are typically the first step for functional annotation of genomic regions.
Vimal Rawat +7 more
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Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs [PDF]
, 2014 The reference annotations made for a genome sequence provide the framework for all subsequent analyses of the genome. Correct and complete annotation in addition to the underlying genomic sequence is particularly important when interpreting the results ...
Junfang Song +29 more
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ANNOTATING GENES USING TEXTUAL PATTERNS [PDF]
Biocomputing 2007, 2006 Annotating genes with Gene Ontology (GO) terms is crucial for biologists to characterize the traits of genes in a standardized way. However, manual curation of textual data, the most reliable form of gene annotation by GO terms, requires significant amounts of human effort, is very costly, and cannot catch up with the rate of increase in biomedical ...
Ali Cakmak 0001, Gultekin Özsoyoglu
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