A rapid change in virulence gene expression during the transition from the intestinal lumen into tissue promotes systemic dissemination of Salmonella. [PDF]
, 2010 Bacterial pathogens causing systemic disease commonly evolve from organisms associated with localized infections but differ from their close relatives in their ability to overcome mucosal barriers by mechanisms that remain incompletely understood.
Andrews-Polymenis, Helene L. +7 more
core +5 more sources
Toll-like Receptor 2 and 4 (TLR2 and TLR4) Agonists Differentially Regulate Secretory Interleukin-1 Receptor Antagonist Gene Expression in Macrophages [PDF]
, 2002 Treatment of macrophages with lipopolysaccharide (LPS) from Gram-negative bacteria or peptidoglycan (PGN) from Gram-positive bacteria activates multiple intracellular signaling pathways and a large, diverse group of nuclear transcription factors.
Brown-Steinke, K. +3 more
core +1 more source
Control of Bacterial Sulfite Detoxification by Conserved and Species-Specific Regulatory Circuits
Frontiers in Microbiology, 2019 Although sulfite, a by-product of the degradation of many sulfur compounds, is highly reactive and can cause damage to DNA, proteins and lipids, comparatively little is known about the regulation of sulfite-oxidizing enzyme (SOEs) expression.
Yi Jie Chelsea Tan +8 more
doaj +1 more source
Do small RNAs unlock the below ground microbiome-plant interaction mystery?
Frontiers in Molecular Biosciences, 2022 Over the past few decades, regulatory RNAs, such as small RNAs (sRNAs), have received increasing attention in the context of host-microbe interactions due to their diverse roles in controlling various biological processes in eukaryotes.
Roshan Regmi +8 more
doaj +1 more source
mBio, 2022 Despite being in a golden age of bacterial epigenomics, little work has systematically examined the plasticity and functional impacts of the bacterial DNA methylome.
Jeffrey S. Bourgeois +7 more
doaj +1 more source
miRNA/phasiRNA mediated regulation of plant defense response against P. syringae [PDF]
, 2018 Gene silencing is a mechanism of regulation of gene expression where the small RNAs (sRNAs) are key components for giving specificity to the system. In plants, two main types of noncoding small RNA molecules have been found: microRNAs (miRNAs) and small ...
Del Espino Pérez, Ángel +7 more
core
Co-PATHOgenex web application for assessing complex stress responses in pathogenic bacteria
Microbiology SpectrumPathogenic bacteria encounter various stressors while residing in the host. They respond through intricate mechanisms of gene expression regulation, ensuring their survival and adaptation.
Leyden Fernandez +4 more
doaj +1 more source
Regulation of bacterial gene expression by the NTP substrates of transcription initiation [PDF]
Molecular Microbiology, 2008 SummaryMany mechanisms of gene regulation in bacteria do not employ repressor or activator proteins. One class of these mechanisms includes those in which the key regulatory element is the control of transcription initiation by the availability of NTP substrates.
openaire +3 more sources
Bacterial Bioluminescence Regulates Expression of a Host Cryptochrome Gene in the Squid-Vibrio Symbiosis [PDF]
mBio, 2013 ABSTRACTThe symbiosis between the squidEuprymna scolopesand its luminous symbiont,Vibrio fischeri, is characterized by daily transcriptional rhythms in both partners and daily fluctuations in symbiont luminescence. In this study, we sought to determine whether symbionts affect host transcriptional rhythms. We identified two transcripts in host tissues (
Michael A. Apicella +5 more
openaire +4 more sources
Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes
Scientific Reports, 2022 AbstractLithium is rare in Earth’s crust compared to the biologically relevant alkali metal cations sodium and potassium but can accumulate to toxic levels in some environments. We report the experimental validation of two distinct bacterial riboswitch classes that selectively activate gene expression in response to elevated Li+ concentrations.
Neil White +4 more
openaire +3 more sources