Results 91 to 100 of about 562,158 (338)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Harnessing Epigenetic Modifiers Reveals MAPK-Mediated Regulation Mechanisms in Hadal Fungi of Alternaria alternata Under High Hydrostatic Pressure

Journal of Fungi
High hydrostatic pressure (HHP) significantly modulates microbial metabolism, while chemical epigenetic modifiers are known to reactivate silent biosynthetic gene clusters and induce novel natural products.
Qingqing Peng, Qifei Wei, Xi Yu
doaj   +1 more source

Regulation of meiotic gene expression is functional in the human fungal pathogen Candida glabrata

FEMS Yeast Research
Abstract The human fungal pathogen Candida glabrata is closely related to the budding yeast Saccharomyces cerevisiae. The sexual cycle in S. cerevisiae has been extensively characterized. Haploid cells ‘a’ and alpha secrete pheromones involved in mating of the opposite cell type leading to the formation of a diploid cell.
Natalia Klimova, Cindy Ngov, Frédéric Devaux, Bernard Turcotte   +3 more
openaire   +2 more sources

Differential expression of the hexose‐regulated fungal genes AmPAL and AmMst1 within Amanita/Populus ectomycorrhizas [PDF]

New Phytologist, 2001
Summary  At least three fungal ‘networks’ are formed in ectomycorrhizal symbiosis: the Hartig net, the sheath and extramatrical hyphae. Since these structures have different functions regarding uptake, storage and partitioning of carbohydrates and nutrients, regulation and coordination of metabolic fluxes are of special interest for ectomycorrhizal ...
Uwe Nehls, Andrea Bock, Margret Ecke, Rüdiger Hampp   +3 more
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transcriptome Analysis Reveals Candidate Genes for Light Regulation of Elsinochrome Biosynthesis in Elsinoë arachidis

Microorganisms
Light regulation is critical in fungal growth, development, morphogenesis, secondary metabolism, and the biological clock. The fungus Elsinoë arachidis is known to produce the mycotoxin Elsinochrome (ESC), a key factor contributing to its pathogenicity ...
Dan Liu, Jingzi Piao, Yang Li, Haiwen Guan, Jingwen Hao, Rujun Zhou   +5 more
doaj   +1 more source

Transcriptome analysis of silkworm, Bombyx mori, during early response to Beauveria bassiana challenges. [PDF]

PLoS ONE, 2014
Host-pathogen interactions are complex processes and it is a central challenge to reveal these interactions. Fungal infection of silkworm, Bombyx mori, may induce a variety of responsive reaction. However, little is known about the molecular mechanism of
Chengxiang Hou, Guangxing Qin, Ting Liu, Tao Geng, Kun Gao, Zhonghua Pan, Heying Qian, Xijie Guo   +7 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Harnessing the Tet-Off system for effective gene silencing in Magnaporthe oryzae

Frontiers in Plant Science
Rice blast is the most serious fungal disease affecting rice production worldwide. Studying gene function in the rice-blast fungus Magnaporthe oryzae often presents significant challenges, especially if it involves loci that are essential for the fungal ...
Zhenyu Fang, Zhenyu Fang, Fan Yang, Yongge Ma, Yongge Ma, Yan Cai, Yan Cai, Xin Chen, Xin Chen, Shiyu Yang, Shiyu Yang, Abubakar Yakubu Saddeeq, Abubakar Yakubu Saddeeq, Zonghua Wang, Zonghua Wang, Zonghua Wang, Naweed I. Naqvi, Wenhui Zheng, Wenhui Zheng   +18 more
doaj   +1 more source

Transcriptional Profiles Uncover Aspergillus flavus-Induced Resistance in Maize Kernels

Toxins, 2011
Aflatoxin contamination caused by the opportunistic pathogen A. flavus is a major concern in maize production prior to harvest and through storage.
Zhi-Yuan Chen, Abebe Menkir, Jiujiang Yu, Deepak Bhatnagar, Robert L. Brown, Meng Luo   +5 more
doaj   +1 more source