Tightly regulated expression of Autographa californica multicapsid nucleopolyhedrovirus immediate early genes emerges from their interactions and possible collective behaviors. [PDF]
PLoS ONE, 2015 To infect their hosts, DNA viruses must successfully initiate the expression of viral genes that control subsequent viral gene expression and manipulate the host environment.
Chikako Ono +5 more
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Viruses, 2022 African swine fever virus (ASFV) has become a global threat to the pig production industry and has caused enormous economic losses in many countries in recent years. Peripheral blood mononuclear cells (PBMCs) from pigs infected with ASFV not only express
Ann Sofie Olesen +7 more
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Pharmacologically regulated gene expression in the retina following transduction with viral vectors [PDF]
Gene Therapy, 2001 The availability of inducible expression systems makes regulatable control of therapeutic proteins an attainable goal in gene therapy. We delivered tetracycline-inducible transgenes to the subretinal space using recombinant adenoviruses. Upon administration of doxycycline, we demonstrated reversible expression of green fluorescent protein in the ...
DEJNEKA N. +6 more
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The nuclear lamina binds the EBV genome during latency and regulates viral gene expression [PDF]
PLOS Pathogens, 2021 The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals. In latently infected cells, the EBV genome persists as a chromatinized episome that expresses a limited set of viral ...
Lisa Beatrice Caruso +9 more
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IFN-Gamma Inhibits JC Virus Replication in Glial Cells by Suppressing T-Antigen Expression. [PDF]
PLoS ONE, 2015 Patients undergoing immune modulatory therapies for the treatment of autoimmune diseases such as multiple sclerosis, and individuals with an impaired-immune system, most notably AIDS patients, are in the high risk group of developing progressive ...
Francesca Isabella De-Simone +6 more
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Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression [PDF]
Cell Host & Microbe, 2019 How the covalent modification of mRNA ribonucleotides, termed epitranscriptomic modifications, alters mRNA function remains unclear. One issue has been the difficulty of quantifying these modifications. Using purified HIV-1 genomic RNA, we show that this RNA bears more epitranscriptomic modifications than the average cellular mRNA, with 5 ...
Courtney, David G. +8 more
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Control of stochastic gene expression by host factors at the HIV promoter.
PLoS Pathogens, 2009 The HIV promoter within the viral long terminal repeat (LTR) orchestrates many aspects of the viral life cycle, from the dynamics of viral gene expression and replication to the establishment of a latent state. In particular, after viral integration into
John C Burnett +4 more
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The [KIL-d] Element Specifically Regulates Viral Gene Expression in Yeast [PDF]
Genetics, 2000 AbstractThe cytoplasmically inherited [KIL-d] element epigenetically regulates killer virus gene expression in Saccharomyces cerevisiae. [KIL-d] results in variegated defects in expression of the M double-stranded RNA viral segment in haploid cells that are “healed” in diploids.
Z, Tallóczy +4 more
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Expanding the role of Drosha to the regulation of viral gene expression [PDF]
Proceedings of the National Academy of Sciences, 2011 It is well-appreciated that viruses use host effectors for macromolecular synthesis and as regulators of viral gene expression. Viruses can encode their own regulators, but often use host-encoded factors to optimize replication. Here, we show that Drosha, an endoribonuclease best known for its role in the biogenesis of microRNAs (miRNAs), can also ...
Yao-Tang, Lin, Christopher S, Sullivan
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Variable episomal silencing of a recombinant herpesvirus renders its encoded GFP an unreliable marker of infection in primary cells. [PDF]
PLoS ONE, 2014 The availability of reliable recombinant reporter virus systems has been a great boon to the study of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8).
Thomas J Ellison, Dean H Kedes
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