Control of stochastic gene expression by host factors at the HIV promoter.
PLoS Pathogens, 2009 The HIV promoter within the viral long terminal repeat (LTR) orchestrates many aspects of the viral life cycle, from the dynamics of viral gene expression and replication to the establishment of a latent state. In particular, after viral integration into
John C Burnett +4 more
doaj +1 more source
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
The [KIL-d] Element Specifically Regulates Viral Gene Expression in Yeast [PDF]
Genetics, 2000 AbstractThe cytoplasmically inherited [KIL-d] element epigenetically regulates killer virus gene expression in Saccharomyces cerevisiae. [KIL-d] results in variegated defects in expression of the M double-stranded RNA viral segment in haploid cells that are “healed” in diploids.
Z, Tallóczy +4 more
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Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes [PDF]
, 2013 Death domain–associated protein (Daxx) cooperates with X-linked α-thalassaemia retardation syndrome protein (ATRX), a putative member of the sucrose non-fermentable 2 family of ATP-dependent chromatin-remodelling proteins, acting as the core ATPase ...
Andreas Mund +92 more
core +1 more source
Circadian control of interferon-sensitive gene expression in murine skin. [PDF]
, 2020 The circadian clock coordinates a variety of immune responses with signals from the external environment to promote survival. We investigated the potential reciprocal relationship between the circadian clock and skin inflammation.
Andersen, Bogi +9 more
core +2 more sources
Expanding the role of Drosha to the regulation of viral gene expression [PDF]
Proceedings of the National Academy of Sciences, 2011 It is well-appreciated that viruses use host effectors for macromolecular synthesis and as regulators of viral gene expression. Viruses can encode their own regulators, but often use host-encoded factors to optimize replication. Here, we show that Drosha, an endoribonuclease best known for its role in the biogenesis of microRNAs (miRNAs), can also ...
Yao-Tang, Lin, Christopher S, Sullivan
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The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons [PDF]
, 2016 open access articleHerpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced.
Coleman, Heather M. +7 more
core +3 more sources
CCCTC-binding factor recruitment to the early region of the human papillomavirus 18 genome regulates viral oncogene expression. [PDF]
, 2015 UNLABELLED: Host cell differentiation-dependent regulation of human papillomavirus (HPV) gene expression is required for productive infection. The host cell CCCTC-binding factor (CTCF) functions in genome-wide chromatin organization and gene regulation ...
Coleman, Nicholas +7 more
core +5 more sources
Importance of codon usage for the temporal regulation of viral gene expression [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance We describe here that different families of persisting viruses consistently use highly unusual codon usage for synthesis of their structural gene products; that the specific nature of the skewed codon usage differs fundamentally from one virus family to another; and that viral-encoded regulatory proteins (specifically Rev of HIV ...
Young C, Shin +3 more
openaire +2 more sources
Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance HIV-1 infects CD4 T cells, and, among these, T helper 17 (Th17) cells are known to be particularly permissive for virus replication. The infection of Th17 cells is critical for AIDS pathogenesis and viral persistence. It is, however, not clear why these cells are highly permissive to HIV-1.
Tomas Raul Wiche Salinas +15 more
openaire +3 more sources