Frontiers in Molecular Biosciences, 2023 Infections by non-segmented negative-strand RNA viruses (NNSV) are widely thought to entail gradient gene expression from the well-established existence of a single promoter at the 3’ end of the viral genome and the assumption of constant transcriptional
Felipe-Andrés Piedra +14 more
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Cell type specific and viral regulation of visna virus gene expression
Virus Research, 1990 Regulation of gene expression of visna virus and other lentiviruses in vivo and in vitro is dependent on both cellular and viral factors. Differentiation and activation of the target cell is essential for transcriptional activation of the viruses. The cellular factors then activate viral transcription and expression of viral genes and viral regulatory ...
J E, Clements, D H, Gabuzda, S L, Gdovin
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Visna virus encodes a post-transcriptional regulator of viral structural gene expression [PDF]
Proceedings of the National Academy of Sciences, 1990 Visna virus is an ungulate lentivirus that is distantly related to the primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1). Replication of HIV-1 and of other complex primate retroviruses, including human T-cell leukemia virus type I (HTLV-I), requires the expression in trans of a virally encoded post-transcriptional activator of
L S, Tiley +5 more
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Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication
Viruses, 2014 UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
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Comparative study of CXC chemokines modulation in brown trout (Salmo trutta) following infection with a bacterial or viral pathogen [PDF]
, 2017 Acknowledgements We would like to acknowledge Richard Paley, Tom Hill and Georgina Rimmer for their collaboration during brown trout infection challenges in CEFAS-Weymouth biosecurity facilities. Bartolomeo Gorgoglione, Stephen W. Feist and Nick G.
Feist, Stephen W. +5 more
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Regulation of Viral Intermediate Gene Expression by the Vaccinia Virus B1 Protein Kinase [PDF]
Journal of Virology, 2001 ABSTRACT The B1 gene of vaccinia virus encodes a serine/threonine protein kinase that is expressed early after infection. Under nonpermissive conditions, temperature-sensitive mutants ( ts 2 and ts 25) that map to B1 fail to efficiently replicate viral DNA.
G R, Kovacs, N, Vasilakis, B, Moss
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Infection of apple by apple stem grooving virus leads to extensive alterations in gene expression patterns but no disease symptoms. [PDF]
PLoS ONE, 2014 To understand the molecular basis of viral diseases, transcriptome profiling has been widely used to correlate host gene expression change patterns with disease symptoms during viral infection in many plant hosts. We used infection of apple by Apple stem
Shanyi Chen +7 more
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Cancer is a side effect of evolution of viruses and bacteria [PDF]
, 2011 Any human organism is home to viruses and bacteria. However, viruses (as well as other intracellular parasites) are interested in continuous division of the host cells.
Valentin Mitin
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The Unique IR2 Protein of Equine Herpesvirus 1 Negatively Regulates Viral Gene Expression [PDF]
Journal of Virology, 2006 ABSTRACT The IR2 protein (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acidic transcriptional activation domain (TAD) and serine-rich tract and yet retaining binding domains for DNA and TFIIB and nuclear localization signal (NLS).
Seong K, Kim +3 more
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Negative regulation of interferon-β gene expression during acute and persistent virus infections. [PDF]
PLoS ONE, 2011 The production of type I interferons (IFNs) in response to viral infections is critical for antiviral immunity. However, IFN production is transient, and continued expression can lead to inflammatory or autoimmune diseases.
Junqiang Ye, Tom Maniatis
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