Results 51 to 60 of about 698,006 (308)

Virus-induced gene complementation reveals a transcription factor network in modulation of tomato fruit ripening [PDF]

, 2012
Plant virus technology, in particular virus-induced gene silencing, is a widely used reverse- and forward-genetics tool in plant functional genomics. However the potential of virus technology to express genes to induce phenotypes or to complement mutants
Fan, Zaifeng, Gallusci, Philippe, Giovannoni, James J., Hong, Yiguo, Jackson, Stephen D., Jin, Mingfei, Lai, Tongfei, Liu, Yule, Qin, Cheng, Rolin, Dominique, Shi, Nongnong, Wang, Huizhong, Wu, Zirong, Zhang, Hang, Zhong, Silin, Zhou, Tao   +15 more
core   +3 more sources

Optimization of the Tet-On system for regulated gene expression through viral evolution [PDF]

Gene Therapy, 2006
The ability to control (trans)gene expression is important both for basic biological research and applications such as gene therapy. In vivo use of the inducible tetracycline (Tc)-regulated gene expression system (Tet-On system) is limited by its low sensitivity for the effector doxycycline (dox).
Zhou, X., Vink, M., Klaver, B., Berkhout, B., Das, A. T.   +4 more
openaire   +3 more sources

YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity

Journal of Virology
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neurodegenerative disease.
Emily M. King, Amanda Midkiff, Karsyn McClain, Sanggu Kim, Amanda R. Panfil   +4 more
doaj   +1 more source

RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]

, 2016
Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan, Ares, Manuel, Batra, Ranjan, Belzile, Jean-Philippe, Bos, Tomas J, Clark, Elizabeth, Donohue, John Paul, Gelboin-Burkhart, Chelsea, Huang, Hui, Huelga, Stephanie C, Rigo, Frank, Roberts, Brett T, Sathe, Shashank, Spector, Deborah H, Stark, Thomas J, Wheeler, Emily C, Yee, Brian A, Yeo, Gene W   +17 more
core   +2 more sources

An adenovirus type 5 early gene function regulates expression of other early viral genes. [PDF]

Proceedings of the National Academy of Sciences, 1979
We have identified an adenovirus type 5(Ad5) early gene function located in early region 1 which is required for the production of early cytoplasmic mRNAs corresponding to early regions 2, 3, and 4. Mutant dl312 (lacks the segment between 1.5 and 4.5 map units) grows as well as wild-type virus in 293 cells (Ad5-transformed human embryonic kidney cells)
N, Jones, T, Shenk
openaire   +2 more sources

Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb. [PDF]

PLoS ONE, 2012
ICP22 is a multifunctional herpes simplex virus 1 (HSV-1) immediate early protein that functions as a general repressor of a subset of cellular and viral promoters in transient expression systems.
Lei Guo, Wen-juan Wu, Long-ding Liu, Li-chun Wang, Ying Zhang, Lian-qiu Wu, Ying Guan, Qi-han Li   +7 more
doaj   +1 more source

Acute BVDV infection inhibits expression of interferon-stimulated genes during pregnancy recognition in bovine endometrium [PDF]

, 2017
Bovine viral diarrhea virus (BVDV) can evade host detection by downregulation of interferon signaling pathways. Infection of cows with noncytopathic (ncp) BVDV can cause early embryonic mortality. Upregulation of type I interferon stimulated genes (ISGs)
Abudureyimu, A, Barry, A T, Chauhan, L, Chen, X, Cheng, Z R, Oguejiofor, C F, Wathes, D C   +6 more
core   +1 more source

Comparative analysis of viral gene expression programs during poxvirus infection: a transcriptional map of the vaccinia and monkeypox genomes. [PDF]

PLoS ONE, 2008
Poxviruses engage in a complex and intricate dialogue with host cells as part of their strategy for replication. However, relatively little molecular detail is available with which to understand the mechanisms behind this dialogue.We designed a ...
Kathleen H Rubins, Lisa E Hensley, George W Bell, Chunlin Wang, Elliot J Lefkowitz, Patrick O Brown, David A Relman   +6 more
doaj   +1 more source

Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding [PDF]

, 2016
Repression of the cellular CIITA gene is part of the immune evasion strategy of the γherpes virus Epstein-Barr virus (EBV) during its lytic replication cycle in B-cells. In part this is mediated through down regulation of MHC class II gene expression via
Adamson, Alison J. Sinclair, Broderick, Crawford, Farrell, Holley-Guthrie, Kay Osborn, Kenney, Kenney, Klug, Mikaélian, Nicolae Balan, Packham, Sinclair, Young   +14 more
core   +1 more source

Chromatin, Non-Coding RNAs, and the Expression of HIV

Viruses, 2013
HIV is a chronic viral infection affecting an estimated 34 million people worldwide. Current therapies employ the use of a cocktail of antiretroviral medications to reduce the spread and effects of HIV, however complete eradication from an individual ...
Jessica N. Groen, Kevin V. Morris
doaj   +1 more source