Results 21 to 30 of about 472,464 (265)
Importance of codon usage for the temporal regulation of viral gene expression [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance We describe here that different families of persisting viruses consistently use highly unusual codon usage for synthesis of their structural gene products; that the specific nature of the skewed codon usage differs fundamentally from one virus family to another; and that viral-encoded regulatory proteins (specifically Rev of HIV ...
Young C, Shin +3 more
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Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance HIV-1 infects CD4 T cells, and, among these, T helper 17 (Th17) cells are known to be particularly permissive for virus replication. The infection of Th17 cells is critical for AIDS pathogenesis and viral persistence. It is, however, not clear why these cells are highly permissive to HIV-1.
Tomas Raul Wiche Salinas +15 more
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Viral Evolution as a Tool to Improve the Tetracycline-regulated Gene Expression System [PDF]
Journal of Biological Chemistry, 2004 We present viral evolution as a novel and powerful method to optimize non-viral proteins. We used this approach to optimize the tetracycline (Tc)-regulated gene expression system (Tet system) for its function in mammalian cells. The components of the Tet system were incorporated in the human immunodeficiency virus (HIV)-1 virus such that viral ...
Das, Atze T. +6 more
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Transcriptional Targeting and MicroRNA Regulation of Lentiviral Vectors
Molecular Therapy: Methods & Clinical Development, 2019 Gene expression regulation is the result of complex interactions between transcriptional and post-transcriptional controls, resulting in cell-type-specific gene expression patterns that are determined by the developmental and differentiation stage of ...
Simone Merlin, Antonia Follenzi
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Unfolding SARS-CoV-2 viral genome to understand its gene expression regulation
Infection, Genetics and Evolution, 2020 SARS-CoV-2 is a new virus responsible for an outbreak of respiratory illness known as COVID-19, which has spread to several countries around the world and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In silico analysis of the transcription start sites, promoter regions, transcription
Dinka, Hunduma, Milkesa, Ashenafi
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Novel RNA Viral Vectors for Chemically Regulated Gene Expression in Embryonic Stem Cells
ACS Synthetic Biology, 2021 RNA viral vectors that replicate without DNA intermediates are attractive platforms for manipulation of cells for biomedical and veterinary applications because they have minimal risk of chromosomal integration. Vesicular stomatitis virus (VSV) vectors are among the most well-studied RNA viral vectors due to their low pathogenicity to humans and ...
Narae Kim, Yohei Yokobayashi
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PLoS Pathogens, 2019 Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ ...
Lauren M Oko +9 more
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Journal of Integrative Bioinformatics, 2023 Hepatocellular carcinoma (HCC) has been associated with hepatitis C viral (HCV) infection as a potential risk factor. Nonetheless, the precise genetic regulatory mechanisms triggered by the virus, leading to virus-induced hepatocarcinogenesis, remain ...
Antropova Evgeniya A. +12 more
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Frontiers in Molecular Biosciences, 2023 Infections by non-segmented negative-strand RNA viruses (NNSV) are widely thought to entail gradient gene expression from the well-established existence of a single promoter at the 3’ end of the viral genome and the assumption of constant transcriptional
Felipe-Andrés Piedra +14 more
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Murine Cytomegalovirus Protein pM92 Is a Conserved Regulator of Viral Late Gene Expression [PDF]
Journal of Virology, 2014 ABSTRACT In this study, we report that murine cytomegalovirus (MCMV) protein pM92 regulates viral late gene expression during virus infection. Previously, we have shown that MCMV protein pM79 and its human cytomegalovirus (HCMV) homologue pUL79 are required for late viral gene transcription.
Chapa, Travis J +3 more
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