Results 21 to 30 of about 3,123,960 (258)

Knockout of EPA1 and EPA6 genes in Candida glabrata and their impact on biofilm formation [PDF]

Zhenduanxue lilun yu shijian
Objective To construct Candida glabrata epithelial adhesin EPA1 and EPA6 gene knockout strains and analyze the effects of gene knockout on the biofilm formation of Candida glabrata.
LIU Jinyan, SONG Yihui, WANG Luling, CHEN Kezhi, ZHAO Juntao, LV Geng, XIANG Mingjie
doaj   +1 more source

Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene [PDF]

, 2010
Beta-carotene 15,15'-monooxygenase 1 knockout (Bcmo1 (-/-)) mice accumulate beta-carotene (BC) similarly to humans, whereas wild-type (Bcmo1 (+/+)) mice efficiently cleave BC.
Yvonne G. J. van Helden, Georg Lietz, Roger W. L. Godschalk, Jaap Keijer, Teerds, K., Hessel, S., Keijer, J., Schooten, F.J., van, Adrian Wyss, von Lintig, J., Sandra G. Heil, Heil, S.G., Kramer, E., Lietz, G., van Schooten, F.J., Lintig, J., von, Amengual, J., Wyss, A., Ribot, J., Katja Teerds, Frederik J. van Schooten, Helden, Y.G.J., Johannes von Lintig, Godschalk, R.W.L., M. Luisa Bonet, van Helden, Y.G., Evelien Kramer, Joan Ribot, Susanne Hessel, Teerds, K.J., Bonet, M.L., Jaume Amengual   +31 more
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Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification [PDF]

, 2010
Peer ...
Ahmad A Mannan, Kadir Tuty, Kazuyuki Shimizu, Andrzej M Kierzek, Tuty Asmawaty Abdul Kadir, McFadden, J, Kadir, TAA, Kadir, Tuty Asmawaty Abdul, Shimizu, K, Kierzek, AM, Kierzek, Andrzej M, Shimizu, Kazuyuki, Kierzek, Andrzej M., McFadden Johnjoe, Mannan, AA, Johnjoe McFadden, Kadir, TA, Mannan, Ahmad A., McFadden, Johnjoe, Shimizu Kazuyuki, Mannan, Ahmad A, Abdul Kadir, Tuty Asmawaty, Mannan Ahmad A, Kierzek Andrzej M, Tuty Kadir   +24 more
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Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice [PDF]

, 2013
International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised.
Mohun, Timothy, Richard Baldock, Andrew J. Copp, Houart, Corinne, Hurles, Matt E., Hemberger, Myriam, Wolfgang Weninger, James C. Smith, Adams, David J, Shoumo Bhattacharya, Bhattacharya, Shoumo, Corinne Houart, Hurles, Matt E, Weninger, W, Weninger, Wolfgang, Timothy Mohun, Tom Weaver, Adams, David J., Smith, James C., Baldock, Richard, Weaver, T, David J. Adams, Adams, DJ, Houart, C, Baldock, R, Mohun, T, Hemberger, M, Copp, Andrew J., Weaver, Tom, Bhattacharya, S, Smith, JC, Elizabeth Robertson, Robertson, E, Copp, Andrew J, Myriam Hemberger, Copp, AJ, Robertson, Elizabeth, Hurles, ME, Matt E. Hurles   +38 more
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Multiplexed CRISPR/Cas9 gene knockout with simple crRNA:tracrRNA co-transfection

Cell & Bioscience, 2019
Background CRISPR/Cas9 mediated gene knockout is a powerful tool for genome editing with the ability to target multiple genes simultaneously. Establishing an efficient, multiplexed gene knockout system using CRISPR/Cas9 that is both simple and robust in ...
Fehad J. Khan, Garmen Yuen, Ji Luo
doaj   +1 more source

Biosynthetic Nanobubble-Mediated CRISPR/Cas9 Gene Editing of Cdh2 Inhibits Breast Cancer Metastasis

Pharmaceutics, 2022
The epithelial-mesenchymal transition (EMT), a process in which epithelial cells undergo a series of biochemical changes to acquire a mesenchymal phenotype, has been linked to tumor metastasis.
Ruru Gao, Qiong Luo, Yang Li, Liming Song, Junnan (Stephen) Cai, Ying Xiong, Fei Yan, Jianhua Liu   +7 more
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Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength [PDF]

, 2012
Osteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput multi-parameter phenotype screen to identify functionally significant skeletal phenotypes in mice ...
Gogakos Apostolos, Campbell, MJ, Anne H. van der Spek (145990), Campbell Michael J., Gogakos, A, Sunter, D, Williams, GR, David Sunter, Bassett, JHD, Boyde, A, Michael J. Campbell (5833), Sunter, D., Richard M Jacques, Project, S.M.G., Alan Boyde (146008), Croucher Peter I., Ramirez-Solis, R, Williams, G.R., Richard M. Jacques (145985), van der Spek Anne H., Holly Evans (145980), Bassett, J.H.D., Ryder, E, Edward Ryder (145998), Peter I. Croucher (146016), Graham R Williams, Evans, H, Bassett J. H. Duncan, Jacques, RM, Anne H van der Spek, J. H. Duncan Bassett (145971), Croucher, PI, Peter I Croucher, Project, SMG, Ryder, E., David Sunter (146002), Holly Evans, Gogakos, A., Jacqueline K. White (119191), Apostolos Gogakos (145975), Ramirez-Solis, R., Jacqueline K White, White Jacqueline K., Boyde, A., van der Spek, A.H., Evans, H., Michael J Campbell, Ramirez-Solis Ramiro, White, J.K., Jacques, R.M., J H Duncan Bassett, Apostolos Gogakos, Jacques Richard M., Croucher, P.I., Ryder Edward, Graham R. Williams (20148), Campbell, M.J., Evans Holly, Ramiro Ramirez-Solis (119181), Williams Graham R., Ramiro Ramirez-Solis, Edward Ryder, Alan Boyde, van der Spek, AH, Sanger Mouse Genetics Project, Sunter David, White, JK, Boyde Alan   +67 more
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Predicting gene knockout effects from expression data

BMC Medical Genomics, 2023
Background The study of gene essentiality, which measures the importance of a gene for cell division and survival, is used for the identification of cancer drug targets and understanding of tissue-specific manifestation of genetic conditions.
Jonathan Rosenski, Sagiv Shifman, Tommy Kaplan   +2 more
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Does change in neurotransmitter brain status affect the growth of transplantable melanoma?

Бюллетень сибирской медицины, 2021
Aim. Studying the influence of the features of aminergic brain status on the development of B16/F10 melanoma in mice with urokinase gene knockout and chronic neurogenic pain (CNP).Material and methods. The study included female (n = 68) С57ВL/6 mice with
O. I. Kit, E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, L. K. Trepitaki, N. D. Cheryarina, I. M. Kotieva   +7 more
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Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
S Eyre, J Worthington, X Ke, P Martin, W Thomson, A Hinks, E Flynn, J Packham, A Barton, Martin, P., Barton, A., Gardner-Medwin, J. [CAPS and BSPAR study groups], UKRAG Consortium, Worthington, J., Thomson, W., Flynn, E., Packham, J., Hinks, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Eyre, S., Ke, X., Childhood Arthritis Prospective Study (CAPS)   +21 more
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