Results 1 to 10 of about 7,554,622 (397)
The Professional Medical Journal, 2018 Objectives: Cancer, the most complex group of genetic disorders results due to over expression or mutation of oncogenes/molecules involved in cell signaling pathways. KRAS is an oncogene that encodes a small GTPase protein with two isoforms KRasA & KRasB and is involved in the regulation of cell division.
Samra Hafiz +2 more
semanticscholar +7 more sources
International Journal of Molecular Sciences, 2022 TRUE gene silencing is an RNA-mediated gene expression control technology and is termed after tRNase ZL-utilizing efficacious gene silencing. In this review, I overview the potentiality of small guide RNA (sgRNA) for TRUE gene silencing as novel therapeutics.
M. Nashimoto
openaire +3 more sources
Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development
Frontiers in Plant Science, 2021 Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism.
Ahmed H. El-Sappah +22 more
doaj +2 more sources
Frontiers in Genetics, 2021 Prediction of growth-related complex traits is highly important for crop breeding. Photosynthesis efficiency and biomass are direct indicators of overall plant performance and therefore even minor improvements in these traits can result in significant ...
Muhammad Farooq +9 more
doaj +1 more source
Gene Activation and Gene Silencing [PDF]
Plant Physiology, 2001 Twenty-five years ago the field of eukaryotic gene regulation was in its infancy. Paradigms driving experiments came primarily from work with prokaryotes and the phage that infected them (12). These paradigms, pioneered by Jacob and Monod, were that genes contained promoter sequences to which ...
V L, Chandler, H, Vaucheret
openaire +2 more sources
Virus‐Induced Gene Silencing, a Post Transcriptional Gene Silencing Method [PDF]
International Journal of Plant Genomics, 2009 Virus‐induced gene silencing (VIGS) is one of the reverse genetics tools for analysis of gene function that uses viral vectors carrying a target gene fragment to produce dsRNA which trigger RNA‐mediated gene silencing. There are a number of viruses which have been modified to silence the gene of interest effectively with a sequence‐specific manner ...
Unver, Turgay, Budak, Hikmet
openaire +3 more sources
Non-Coding RNA, 2021 RNA silencing pathways control eukaryotic gene expression transcriptionally or posttranscriptionally in a sequence-specific manner. In RNA silencing, the production of double-stranded RNA (dsRNA) gives rise to various classes of 20–24 nucleotide (nt ...
Xia Hua +5 more
doaj +1 more source
Targeted gene silencing in vivo by platelet membrane–coated metal-organic framework nanoparticles
Science Advances, 2020 Platelet-mimicking nanoparticles enable the targeted delivery of small interfering RNA to tumors for anticancer therapy. Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biomedical applications ...
Zhuang Jia +6 more
semanticscholar +1 more source
A protein assembly mediates Xist localization and gene silencing
Nature, 2020 Nuclear compartments have diverse roles in regulating gene expression, yet the molecular forces and components that drive compartment formation remain largely unclear1.
Amy Pandya-Jones +17 more
semanticscholar +1 more source
Carbon Dots for Efficient Small Interfering RNA Delivery and Gene Silencing in Plants[OPEN]
Plant Physiology, 2020 The development of a formulation for siRNA delivery enables post-transcriptional gene silencing in plants with a simple spray application. The initiation of RNA interference (RNAi) by topically applied small interfering RNA has potential applications for
Steven H. Schwartz +4 more
semanticscholar +1 more source