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Gene silencing: Cosuppression at a distance [PDF]
Current Biology, 1997 When a plant carries a transgenic copy of an endogenous gene, both genes may be silenced. This 'cosuppression' can occur not only within individual cells, but also in distant cells through an agent that apparently moves through the plant's phloem.
David Smyth
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Gene silencing in worms and fungi [PDF]
Nature, 2000 The introduction into cells of foreign nucleic acid molecules can induce sequence-specific gene silencing in some organisms. Here we show that two distantly related organisms, the nematode Caenorhabditis elegans and the fungus Neurospora crassa, which have quite different mechanisms of gene silencing, both use a similar protein to control the process ...
Caterina Catalanotto +3 more
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Frontiers in Genetics, 2021 Prediction of growth-related complex traits is highly important for crop breeding. Photosynthesis efficiency and biomass are direct indicators of overall plant performance and therefore even minor improvements in these traits can result in significant ...
Muhammad Farooq +9 more
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Proceedings of the National Academy of Sciences, 2004 The genomes of many species, including man, have been laid bare with hundreds of known and thousands of unknown genes. A major challenge in present day biology is to decipher the molecular function of the unknown genes. Gene knockout by homologous recombination has proven to be very useful but is laborious and expensive.
Inder M. Verma, Amiel Yanai, Oded Singer
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Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development
Frontiers in Plant Science, 2021 Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism.
Ahmed H. El-Sappah +22 more
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Non-Coding RNA, 2021 RNA silencing pathways control eukaryotic gene expression transcriptionally or posttranscriptionally in a sequence-specific manner. In RNA silencing, the production of double-stranded RNA (dsRNA) gives rise to various classes of 20–24 nucleotide (nt ...
Xia Hua +5 more
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Gene Activation and Gene Silencing [PDF]
Plant Physiology, 2001 Twenty-five years ago the field of eukaryotic gene regulation was in its infancy. Paradigms driving experiments came primarily from work with prokaryotes and the phage that infected them (12). These paradigms, pioneered by Jacob and Monod, were that genes contained promoter sequences to which ...
Hervé Vaucheret, Vicki L. Chandler
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eLife, 2022 In mammalian cells genes that are in close proximity can be transcriptionally coupled: silencing or activating one gene can affect its neighbors. Understanding these dynamics is important for natural processes, such as heterochromatin spreading during ...
Sarah Lensch +7 more
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Pygmy MicroRNA: Surveillance Cops in Therapy Kingdom
Molecular Medicine, 2016 MicroRNAs (miRNAs) are well preserved in every animal. These pygmy-sized (21–23 nt) noncoding RNAs scattered in the genome are responsible for micromanaging versatile gene regulation.
Utpal Bhadra +3 more
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