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Frontiers in Cell and Developmental Biology, 2022 The adenomatous polyposis coli (APC) gene is the chromatin-remodeling-related gene and a typical tumor suppressor. Patients with a high expression of programmed death-ligand 1 (PD-L1) or a high level of tumor mutational burden (TMB) may benefit from ...
Yunfeng Song +4 more
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Prediction and testing of biological networks underlying intestinal cancer. [PDF]
PLoS ONE, 2010 Colorectal cancer progresses through an accumulation of somatic mutations, some of which reside in so-called "driver" genes that provide a growth advantage to the tumor.
Vishal N Patel +5 more
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Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. [PDF]
PLoS Genetics, 2015 Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated ...
Ying Feng +11 more
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PLoS ONE, 2021 Adenomatous Polyposis Coli (APC) is lost in approximately 70% of sporadic breast cancers, with an inclination towards triple negative breast cancer (TNBC).
Emily M Astarita +6 more
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Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer. [PDF]
PLoS ONE, 2011 Aberrant activation of the Wnt/β-catenin pathway is critical for the initiation and progression of most colon cancers. This activation provokes the accumulation of nuclear β-catenin and the induction of its target genes.
María Jesús Larriba +6 more
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APC Gene Mutations in Human Prostate Cancer [PDF]
Japanese Journal of Clinical Oncology, 1996 Prostate cancer is the most common cancer in aged men. Although ras and p53 gene mutations have been detected in some prostate cancers, the major genetic alterations involved in its carcinogenesis are not well understood. Mutation of the APC gene is responsible for colorectal tumors in which ras and p53 mutations are also often involved. Using PCR-SSCP
M, Watanabe +6 more
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APC Gene Testing for Familial Adenomatosis Polyposis [PDF]
JAMA, 2012 While genomics is destined to revolutionize clinical medicine, to date its beneficial effects have been somewhat muted. The promise and perils of genomics are emblemized by one of its flagship applications, namely the diagnosis of familial adenomatosis polyposis (FAP).
Hemant K, Roy, Janardan D, Khandekar
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APC/C-dependent control of gene expression and cell identity
Nature, 2020 Metazoan development requires the robust proliferation of progenitor cells, the identities of which are established by tightly controlled transcriptional networks1.
E. Oh +9 more
semanticscholar +1 more source
CD24 and APC Genetic Polymorphisms in Pancreatic Cancers as Potential Biomarkers for Clinical Outcome. [PDF]
PLoS ONE, 2015 There are no validated biomarkers that correlate with the prognosis of pancreatic ductal adenocarcinoma (PDA). The CD24 and adenomatous polyposis coli (APC) genes are important in the malignant transformation of gastrointestinal cells.
Sivan Shamai +8 more
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APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer
British Journal of Cancer, 2020 Most cancer cells employ the Warburg effect to support anabolic growth and tumorigenesis. Here, we discovered a key link between Warburg effect and aberrantly activated Wnt/β-catenin signalling, especially by pathologically significant APC loss, in CRC ...
Pu-Hyeon Cha +5 more
semanticscholar +1 more source