Results 231 to 240 of about 241,277 (303)

Genomic and transcriptomic landscape of carcinogenesis in patients with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). [PDF]

Proc Natl Acad Sci U S A
Matsumoto C, Takahashi KK, Iwatsuki M, Yasuda-Yoshihara N, Niida A, Yamashita K, Morinaga T, Eto K, Iwagami S, Ida S, Yano H, Komohara Y, Miyamoto Y, Masuda T, Tanaka Y, Mimori K, Baba H.   +16 more
europepmc   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance. [PDF]

Nature
White M, Mills ML, Millett LM, Gilroy K, Hong Y, Zeiger LB, Simpson RJ, Corry SM, Ligeza A, Lannagan TRM, Susanti S, Ridgway RA, Yazgili AS, Grzesiak L, Amirkhah R, Ford CA, Vlahov N, Tovell H, Officer-Jones L, Ficken C, Pennie R, Najumudeen AK, Raven A, Nasreddin N, Chauhan E, Papanastasiou AS, Nixon C, Morrison V, Jackstadt R, Graham JS, Miller CJ, Ross SJ, Barry ST, Pavet V, Wilson RH, Le Quesne J, Dunne PD, Tejpar S, Leedham S, Campbell AD, Sansom OJ.   +40 more
europepmc   +1 more source

Smartly Assembled near‐Micron RF‐Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation

Advanced Science, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu, Junkang Ding, Lingxiao Zhang, Zhou Tian, Cheng Zeng, Shaomin Zou, Wenjing Zhang, Tangye Zeng, Zhencang Gao, Zhouyi Sun, Gang Liu, Weiyu Chen, Zhe Tang   +12 more
wiley   +1 more source

The use of whole genome sequencing to study young patients with 100+ adenomas of the colon. [PDF]

Front Oncol
Tsukanov AS, Achkasov SI, Loginova AN, Shubin VP, Pikunov DY, Chekanov NN, Salomatina AS, Severinov KV.   +7 more
europepmc   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

Metastatic colorectal adenocarcinoma with APC and EGFR L858R co-mutations: a case report. [PDF]

Oncologist
Cavalheiro VJ, Sobral Filho DSR, de Oliveira GM, da Fonseca MDRN, Travessini G, Soares IC, de Castro Junior G, Sabbaga J, Mak MP, Gehm Hoff PM.   +9 more
europepmc   +1 more source

Characterization of Korean Colorectal Cancer Reveals Novel Driver Gene and Clinically Relevant Mutations. [PDF]

MedComm (2020)
Kang J, Lim DM, Kim YJ, Shim H, Kim TY, Park KJ, Kang SB, Yu CS, Lee JL, Yu Y, Lee H, Kwon EJ, Kim HM, Mun S, Kwak D, Lee HS, Heo HJ, Kim EK, Baek SE, Park JW, Bae SU, Kwon TK, Lee D, Kim K, Oh CK, Ko DS, Cho S, Park HR, Kim S, Kim YH.   +29 more
europepmc   +1 more source

Ubiquitylation-oxaliplatin-related prognosis signature reveals the landscapes of immune responses, cell communication, and therapeutic sensitivity for colorectal cancer. [PDF]

Anticancer Drugs
Zhang G, Chen X.
europepmc   +1 more source