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Age-Related Multigene Analysis of Colorectal Cancer Using Next-Generation Sequencing. [PDF]

Cancers (Basel)
Kozlowska-Geller M, Nawacki Ł, Wawszczak-Kasza M, Lewitowicz W, Bicki J, Lewitowicz P.   +5 more
europepmc   +1 more source

Insights into intramuscular adipose-muscle signaling in the diabetic lower extremity. [PDF]

J Clin Transl Endocrinol
Gui C, Kamm DR, Ferey JLA, Bohnert KL, McCormick JJ, Hastings MK, Meyer GA.   +6 more
europepmc   +1 more source

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The APC gene in colorectal cancer

European Journal of Cancer, 2002
Mutations in the adenomatous polyposis coli (APC) gene are not only responsible for familial adenomatous polyposis (FAP), but also play a rate-limiting role in the majority of sporadic colorectal cancers. Colorectal tumours are known to arise through a gradual series of histological changes, the so-called 'adenoma-carcinoma' sequence, each accompanied ...
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Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene

Anatomical Science International, 2005
The adenomatous polyposis coli (Apc) gene is mutated in familial adenomatous polyposis and in sporadic colorectal tumors. The Apc gene product (APC), basically a cytoplasmic protein, blocks cell cycle progression and plays crucial roles in development.
Takao, Senda, Atsushi, Shimomura, Akiko, Iizuka-Kogo   +2 more
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The Many Faces of the Tumor Suppressor Gene APC

Experimental Cell Research, 2001
Inactivation of the tumor suppressor adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer. Close examination of the function of APC has shown that it is a multifunctional protein involved in a wide variety of processes, including regulation of cell proliferation, cell migration, cell
Es, J.H. van, Giles, R.H., Clevers, J.C.
openaire   +3 more sources