Results 21 to 30 of about 5,527,747 (326)
E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]
, 2015 Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke +27 more
core +2 more sources
p53 and APC gene mutations: software and databases [PDF]
Nucleic Acids Research, 1997 A large number of different mutations in the APC and p53 tumor suppressor genes have been identified in various types of cancer. This substantial increase since our previous reports can enable analyses which were not previously possible. In order to capture all these new data, the software permitting analysis has been improved.
C, Béroud, T, Soussi
openaire +2 more sources
Baculovirus expression: tackling the complexity challenge [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Barford, David +3 more
core +2 more sources
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling
BMC Bioinformatics, 2010 Background Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified over the years, it is not always clear which functions or interactions are ...
Patel Vishal +2 more
doaj +1 more source
Recurrent APC gene mutations in Polish FAP families [PDF]
Hereditary Cancer in Clinical Practice, 2007 The molecular diagnostics of genetically conditioned disorders is based on the identification of the mutations in the predisposing genes. Hereditary cancer disorders of the gastrointestinal tracts are caused by mutations of the tumour suppressor genes or the DNA repair genes. Occurrence of recurrent mutation allows improvement of molecular diagnostics.
Pławski Andrzej +2 more
openaire +3 more sources
Cáncer colorrectal hereditario: análisis molecular de los genes APC y MLH1
, 2006 Two FAP andone HNPCC families were studied. The APC gene (for FAP patients) and the MLH1 gene (forHNPCC patients), were screened for mutations on genomic DNA.
R. FelipeBellolio +7 more
semanticscholar +1 more source
Orphanet Journal of Rare Diseases, 2013 BackgroundPatients with multiple colorectal adenomas are currently screened for germline mutations in two genes, APC and MUTYH. APC-mutated patients present classic or attenuated familial adenomatous polyposis (FAP/AFAP), while patients carrying ...
G. Torrezan +7 more
semanticscholar +1 more source
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Methylation of multiple genes in hepatitis C virus associated hepatocellular carcinoma
Journal of Advanced Research, 2014 We studied promoter methylation (PM) of 11 genes in Peripheral Blood Lymphocytes (PBLs) and tissues of hepatitis C virus (HCV) associated hepatocellular carcinoma (HCC) and chronic hepatitis (CH) Egyptian patients.
Abdel-Rahman N. Zekri +8 more
doaj +1 more source
Genes & Development, 2013 Mutation of the APC tumor suppressor stabilizes β-catenin and aberrantly reactivates Wnt/β-catenin target genes in colon cancer. Here, Choi et al. perform proteomic analysis of Wnt/β-catenin regulator complexes and uncover a role for the tumor suppressor
S. Choi +4 more
semanticscholar +1 more source