Results 31 to 40 of about 5,527,747 (326)

Influence of some methylated hepatocarcinogenesis-related genes on the response to antiviral therapy and development of fibrosis in chronic hepatitis C patients [PDF]

Clinical and Molecular Hepatology, 2020
Background and Aim Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients ...
Waleed Seif Eldin Mohamed Mostafa, Mohammed Hassan Saiem Al-Dahr, Dalia Abdel Hamid Omran, Zeinab Fathy Abdullah, Suzan Hamdy Elmasry, Mohamed Nabil Ibrahim   +5 more
doaj   +1 more source

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene [PDF]

Human Molecular Genetics, 1992
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mutations were detected.
Y, Miyoshi, H, Nagase, H, Ando, A, Horii, S, Ichii, S, Nakatsuru, T, Aoki, Y, Miki, T, Mori, Y, Nakamura   +9 more
openaire   +2 more sources

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation [PDF]

, 2013
A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT ...
A Gregorieff, A Horii, A Jung, A Novak, AC de Vries, AN Milne, AT Franco, B Kim, B Tycko, C Cavard, D Athineos, D M Pritchard, DM Parkin, E Half, E Tahara, EF Chan, G Gatta, H Guillen-Ahlers, H Ireland, H Luche, H Nagase, H Oshima, H Shibata, H Watanabe, H Zhang, HC Zheng, HJ Freeman, J Cordero, J Neumann, J Parsonnet, J Woodgett, JG Forte, K Miyazawa, K Oien, KF Becker, KW Kinzler, LK Bianchi, M Crabtree, M Iida, M Nakayama, M Shitashige, M Suzuki, M Suzuki, M Torbenson, MG Smith, MP Ebert, N Barker, N Barker, N Barker, N Barker, N Barker, N Harada, N Murata-Kamiya, N Uemura, O J Sansom, O Sokolova, O Tetsu, OJ Sansom, P Blache, P Correa, P Correa, P Lauren, P Salgueiro, P Soriano, PJ Guilford, R A Ridgway, R Kemp, R Poulsom, S Garrean, S Nakatsuru, S Patel, S Patel, S Radulescu, S Segditsas, S Sekine, SC Abraham, SC Abraham, SM Przemeck, SS Ng, T Gnad, T Oda, TC He, WM Clements, WS Park, XC He, Y Miyoshi, Y Park do, Z Spicer, Z Zhao   +88 more
core   +1 more source

Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis.

PLoS ONE, 2021
The spectrum of somatic genetic variation in colorectal adenomas caused by biallelic pathogenic germline variants in the MSH3 gene, was comprehensively analysed to characterise mutational signatures and identify potential driver genes and pathways of ...
Claudia Perne, Sophia Peters, Maria Cartolano, Sukanya Horpaopan, Christina Grimm, Janine Altmüller, Anna K Sommer, Axel M Hillmer, Holger Thiele, Margarete Odenthal, Gabriela Möslein, Ronja Adam, Sugirthan Sivalingam, Jutta Kirfel, Michal R Schweiger, Martin Peifer, Isabel Spier, Stefan Aretz   +17 more
doaj   +1 more source

Somatic Mutation Rate of the APC Gene [PDF]

Japanese Journal of Clinical Oncology, 2001
Somatic inactivation of the wild-type APC gene is involved in the development of adenoma of familial adenomatous polyposis. This situation is also true in sporadic adenomas. It is of biological interest to know the somatic mutation rate of the APC gene.The number of stem cells of the colon (N) and somatic mutation rate of the APC gene in a stem cell in
openaire   +2 more sources

Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer

Revista de Gastroenterología de México (English Edition), 2014
Background: Stomach cancer (SC) and colorectal cancer (CRC) present with high rates of incidence and mortality in the worldwide population. These 2 tumors are characterized by great genetic heterogeneity.
K.A. Palacio-Rúa, L.F. Isaza-Jiménez, E. Ahumada-Rodríguez, H. Ceballos-García, C.M. Muñetón-Peña   +4 more
doaj   +1 more source

Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions.

PLoS ONE, 2020
Computational algorithms are often used to assess pathogenicity of Variants of Uncertain Significance (VUS) that are found in disease-associated genes. Most computational methods include analysis of protein multiple sequence alignments (PMSA), assessing ...
Alexander D Karabachev, Dylan J Martini, David J Hermel, Dana Solcz, Marcy E Richardson, Tina Pesaran, Indra Neil Sarkar, Marc S Greenblatt   +7 more
doaj   +1 more source

Meningiomas exhibit loss of heterozygosity of the APC gene [PDF]

Journal of Neuro-Oncology, 2007
The molecular mechanisms and candidate genes involved in development of meningiomas still need investigation and elucidation. In the present study 33 meningiomas were analyzed regarding genetic changes of tumor suppressor gene Adenomatous polyposis coli (APC), a component of the wnt signaling.
Pećina-Šlaus, Nives, Nikuševa Martić, Tamara, Tomas, Davor, Beroš, Vili, Zeljko, Martina, Čupić, Hrvoje   +5 more
openaire   +7 more sources

Expression of inflammation-related genes is associated with adipose tissue location in horses [PDF]

, 2013
Background : In humans, adipose tissue (AT) originating from different depots shows varying gene expression profiles. In horses, the risk of certain metabolic disorders may also be influenced by the impact of specific AT depots.
Bruynsteen, Lien, Ducatelle, Richard, Erkens, Tim, Harris, Patricia, Hesta, Myriam, Janssens, Geert, Peelman, Luc   +6 more
core   +2 more sources

A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC

Nature Communications, 2016
Colorectal cancer (CRC) is a highly heterogeneous disease, for which prognosis has been relegated to clinicopathologic staging for decades. There is a need to stratify subpopulations of CRC on a molecular basis to better predict outcome and assign ...
M. Schell, Mingli Yang, J. Teer, F. Y. Lo, A. Madan, D. Coppola, Alvaro N. A. Monteiro, M. Nebozhyn, Binglin Yue, A. Loboda, G. Bien-Willner, D. Greenawalt, T. Yeatman   +12 more
semanticscholar   +1 more source