Results 51 to 60 of about 5,527,747 (326)
Epigenetic Changes in Tumor Suppressor Genes, P15, P16, APC-3 and E-cadherin in Body Fluid
Kaohsiung Journal of Medical Sciences, 2007 The inactivation of tumor suppressor genes by promoter methylation plays an important role in the development of cancers; it can also be used as a marker to distinguish cancerous cells from non-cancer cells.
Mei-Ling Chen +4 more
doaj +1 more source
Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis. [PDF]
PLoS ONE, 2013 Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and Apc ...
Mehrnaz Ghazvini +9 more
doaj +1 more source
BMC Cancer, 2005 BackgroundThe early to intermediate stages of the majority of colorectal tumours are thought to be driven by aberrations in the Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A smaller proportion of cancers shows mismatch repair deficiency.
M. Lüchtenborg +9 more
semanticscholar +1 more source
Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core +1 more source
Current Issues in Molecular Biology, 2022 This study aims at identifying common pathogenic somatic mutations at different stages of colorectal carcinogenesis in Egyptian patients. Our cohort included colonoscopic biopsies collected from 120 patients: 20 biopsies from patients with inflammatory ...
Amira Salah El-Din Youssef +10 more
doaj +1 more source
MYH Gene Status in Polish FAP Patients without APC Gene Mutations [PDF]
Hereditary Cancer in Clinical Practice, 2006 Familial Adenomatous Polyposis (FAP) is an inheritable predisposition for the occurrence of numerous polyps in the large intestine. In about 50% of all patients, the occurrence of the disease is conditioned by heterozygotic mutations of the APC gene. Screening for genetic factors in persons without mutations in the APC gene led to the identification of
Skrzypczak Marzena +6 more
openaire +3 more sources
Role of APC and DNA mismatch repair genes in the development of colorectal cancers
Molecular Cancer, 2003 Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S ...
S. Narayan, D. Roy
semanticscholar +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
BMC Cancer, 2010 Background We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, by utilizing the difference in genomic location of orthologous genes between the human and other mammals.
Ji Xinglai +8 more
doaj +1 more source
Mutational profile of KRAS-positive colorectal cancer
Сибирский онкологический журнал, 2022 Aim: to study the features of the molecular genetic profile of KRAS-positive colorectal cancer (CRC).Material and Methods. The study included 42 patients diagnosed with colorectal cancer.
E. N. Telysheva +2 more
doaj +1 more source