Results 1 to 10 of about 224,267 (330)

The tammar wallaby major histocompatibility complex shows evidence of past genomic instability [PDF]

BMC Genomics, 2011
Background The major histocompatibility complex (MHC) is a group of genes with a variety of roles in the innate and adaptive immune responses. MHC genes form a genetically linked cluster in eutherian mammals, an organization that is thought to confer ...
Harrow Jennifer, Whilming Laurens, Coggill Penny, Deakin Janine E, Siddle Hannah V, Kaufman Jim, Beck Stephan, Belov Katherine   +7 more
doaj   +8 more sources

Evolution of major histocompatibility complex class I and class II genes in the brown bear [PDF]

BMC Evolutionary Biology, 2012
Background Major histocompatibility complex (MHC) proteins constitute an essential component of the vertebrate immune response, and are coded by the most polymorphic of the vertebrate genes.
Kuduk Katarzyna, Babik Wiesław, Bojarska Katarzyna, Śliwińska Ewa B, Kindberg Jonas, Taberlet Pierre, Swenson Jon E, Radwan Jacek   +7 more
doaj   +8 more sources

The primate Major Histocompatibility Complex as a case study of gene family evolution [PDF]

eLife
Gene families are groups of evolutionarily related genes. One large gene family that has experienced rapid evolution lies within the Major Histocompatibility Complex (MHC), whose proteins serve critical roles in innate and adaptive immunity.
Alyssa Lyn Fortier, Jonathan K Pritchard
doaj   +2 more sources

Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population [PDF]

Anais Brasileiros de Dermatologia, 2016
: Background: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic.
Ângela Marques Barbosa, Luiz Euribel Prestes-Carneiro, Aldri Roberta Sodoschi Sobral, Marcelo Jun Sakiyama, Bruna Cerávolo Lemos, Marilda Aparecida Milanez Morgado de Abreu, Luciana Leite Crivelin Martos, Ricardo Alberto Moliterno   +7 more
doaj   +1 more source

Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Frontiers in Cell and Developmental Biology, 2023
Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S. Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida   +5 more
doaj   +1 more source

Allelic diversity and patterns of selection at the major histocompatibility complex class I and II loci in a threatened shorebird, the Snowy Plover (Charadrius nivosus)

BMC Evolutionary Biology, 2020
Background Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics.
Medardo Cruz-López, Guillermo Fernández, Helen Hipperson, Eduardo Palacios, John Cavitt, Daniel Galindo-Espinosa, Salvador Gómez del Angel, Raya Pruner, Oscar Gonzalez, Terry Burke, Clemens Küpper   +10 more
doaj   +1 more source

Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae

BMC Genomics, 2020
Background The mammalian Major Histocompatibility Complex (MHC) is a genetic region containing highly polymorphic genes with immunological functions. MHC class I and class II genes encode antigen-presenting molecules expressed on the cell surface.
Marie Klumplerova, Petra Splichalova, Jan Oppelt, Jan Futas, Aneta Kohutova, Petra Musilova, Svatava Kubickova, Roman Vodicka, Ludovic Orlando, Petr Horin   +9 more
doaj   +1 more source

Multiple expressed MHC class II loci in salmonids; details of one non-classical region in Atlantic salmon (Salmo salar)

BMC Genomics, 2008
Background In teleosts, the Major Histocompatibility Complex (MHC) class I and class II molecules reside on different linkage groups as opposed to tetrapods and shark, where the class I and class II genes reside in one genomic region. Several teleost MHC
Bakke Hege G, Lukacs Morten F, Harstad Håvard, Grimholt Unni   +3 more
doaj   +1 more source

Major histocompatibility complex genomic investigation of endangered Chinese alligator provides insights into the evolution of tetrapod major histocompatibility complex and survival of critically bottlenecked species

Frontiers in Ecology and Evolution, 2022
BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He, Ke He, Ying Zhu, Ying Zhu, Shang-Chen Yang, Qing Ye, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan   +8 more
doaj   +1 more source

Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression [PDF]

, 1996
CIITA activates the expression of multiple genes involved in antigen presentation and it is believed to be required for both constitutive and IFN\xce\xb3-inducible expression of these genes.
Chang, C.-H. (Cheong-Hee), Ewijk, W. (Willem) van, Flavell, R.A. (Richard), Guerder, S. (Sylvie), Hong, S.-C. (Soon-Cheol)   +4 more
core   +1 more source