Results 1 to 10 of about 520,767 (241)

Multiple expressed MHC class II loci in salmonids; details of one non-classical region in Atlantic salmon (Salmo salar) [PDF]

BMC Genomics, 2008
Background In teleosts, the Major Histocompatibility Complex (MHC) class I and class II molecules reside on different linkage groups as opposed to tetrapods and shark, where the class I and class II genes reside in one genomic region. Several teleost MHC
Bakke Hege G, Lukacs Morten F, Harstad Håvard, Grimholt Unni   +3 more
doaj   +5 more sources

Allelic diversity and patterns of selection at the major histocompatibility complex class I and II loci in a threatened shorebird, the Snowy Plover (Charadrius nivosus) [PDF]

BMC Evolutionary Biology, 2020
Background Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics.
Medardo Cruz-López, Guillermo Fernández, Helen Hipperson, Eduardo Palacios, John Cavitt, Daniel Galindo-Espinosa, Salvador Gómez del Angel, Raya Pruner, Oscar Gonzalez, Terry Burke, Clemens Küpper   +10 more
doaj   +3 more sources

The tammar wallaby major histocompatibility complex shows evidence of past genomic instability [PDF]

BMC Genomics, 2011
Background The major histocompatibility complex (MHC) is a group of genes with a variety of roles in the innate and adaptive immune responses. MHC genes form a genetically linked cluster in eutherian mammals, an organization that is thought to confer ...
Harrow Jennifer, Whilming Laurens, Coggill Penny, Deakin Janine E, Siddle Hannah V, Kaufman Jim, Beck Stephan, Belov Katherine   +7 more
doaj   +8 more sources

Evolution of major histocompatibility complex class I and class II genes in the brown bear [PDF]

BMC Evolutionary Biology, 2012
Background Major histocompatibility complex (MHC) proteins constitute an essential component of the vertebrate immune response, and are coded by the most polymorphic of the vertebrate genes.
Kuduk Katarzyna, Babik Wiesław, Bojarska Katarzyna, Śliwińska Ewa B, Kindberg Jonas, Taberlet Pierre, Swenson Jon E, Radwan Jacek   +7 more
doaj   +7 more sources

Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat. [PDF]

PLoS Genetics, 2014
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved.
Jonatan Tuncel, Sabrina Haag, Anthony C Y Yau, Ulrika Norin, Amelie Baud, Erik Lönnblom, Klio Maratou, A Jimmy Ytterberg, Diana Ekman, Soley Thordardottir, Martina Johannesson, Alan Gillett, EURATRANS Consortium, Pernilla Stridh, Maja Jagodic, Tomas Olsson, Alberto Fernández-Teruel, Roman A Zubarev, Richard Mott, Timothy J Aitman, Jonathan Flint, Rikard Holmdahl   +21 more
doaj   +8 more sources

Correlation in chicken between the marker LEI0258 alleles and Major Histocompatibility Complex sequences [PDF]

BMC Proceedings, 2011
Background The LEI0258 marker is located within the B region of the chicken Major Histocompatibility Complex (MHC), and is surprisingly well associated with serology.
Chazara Olympe, Juul-Madsen Helle, Chang Chi-Sheng, Tixier-Boichard Michele, Bed’hom Bertrand   +4 more
doaj   +4 more sources

Gene duplication and fragmentation in the zebra finch major histocompatibility complex [PDF]

BMC Biology, 2010
Background Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of particular interest because the chicken
Burt David W, Kotkiewicz Holly, Godinez Ricardo, Westerdahl Helena, Völker Martin, Ekblom Robert, Balakrishnan Christopher N, Graves Tina, Griffin Darren K, Warren Wesley C, Edwards Scott V   +10 more
doaj   +8 more sources

Mice lacking all conventional MHC class II genes [PDF]

Proceedings of the National Academy of Sciences, 1999
MHC class II (MHC-II) molecules play a central role in the selection of the T cell repertoire, in the establishment and regulation of the adaptive immune response, and in autoimmune deviation. We have generated knockout mice lacking all four of the classical murine MHC-II genes (MHCIIΔ/Δmice), via a large (80-kilobase) deletion of the entire class II ...
Nathalie Labrecque, Arne Svejgaard, Jan Engberg, Andrée Dierich, Christophe Benoist, Diane Mathis, Lars Madsen, Lars Fugger   +7 more
openaire   +4 more sources

Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes [PDF]

Nucleic Acids Research, 2006
The small GTPase RAB4 regulates endocytic recycling, a process that contributes to Major Histocompatibility Complex (MHC)-mediated antigen presentation by specialized antigen presenting cells (APC) of the immune system.
Barras, Emmanuèle, Dunand-Sauthier, Isabelle, Krawczyk, Michal, Leimgruber, Elisa, Reith, Walter, Seguín-Estévez, Queralt   +5 more
core   +3 more sources

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. [PDF]

PLoS Biology, 2006
The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used the Monodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex
Katherine Belov, Janine E Deakin, Anthony T Papenfuss, Michelle L Baker, Sandra D Melman, Hannah V Siddle, Nicolas Gouin, David L Goode, Tobias J Sargeant, Mark D Robinson, Matthew J Wakefield, Shaun Mahony, Joseph G R Cross, Panayiotis V Benos, Paul B Samollow, Terence P Speed, Jennifer A Marshall Graves, Robert D Miller   +17 more
doaj   +8 more sources