Results 11 to 20 of about 224,267 (330)

Mice lacking all conventional MHC class II genes. [PDF]

Proceedings of the National Academy of Sciences, 1999
MHC class II (MHC-II) molecules play a central role in the selection of the T cell repertoire, in the establishment and regulation of the adaptive immune response, and in autoimmune deviation. We have generated knockout mice lacking all four of the classical murine MHC-II genes (MHCIIΔ/Δmice), via a large (80-kilobase) deletion of the entire class II ...
L. Madsen, N. Labrecque, J. Engberg, A. Dierich, A. Svejgaard, C. Benoist, D. Mathis, L. Fugger   +7 more
semanticscholar   +3 more sources

Cohesin Regulates MHC Class II Genes through Interactions with MHC Class II Insulators [PDF]

The Journal of Immunology, 2011
Abstract Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains.
P. Majumder, J. Boss
semanticscholar   +3 more sources

Mutation of RFXAP, a regulator of MHC class II genes, in primary MHC class II deficiency.

New England Journal of Medicine, 1997
Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive primary immunodeficiency disease in which MHC class II molecules are absent. It is a genetically heterogeneous disease of gene regulation resulting from defects in several transactivating genes that regulate the expression of MHC class II genes.
J. Villard, B. Lisowska‐Grospierre, P. J. van den Elsen, A. Fischer, W. Reith, B. Mach   +5 more
semanticscholar   +4 more sources

Allelic diversity and selection at the MHC class I and class II in a bottlenecked bird of prey, the White-tailed Eagle

BMC Evolutionary Biology, 2019
Background Genes of the Major Histocompatibility Complex (MHC) are essential for adaptive immune response in vertebrates, as they encode receptors that recognize peptides derived from the processing of intracellular (MHC class I) and extracellular (MHC ...
Piotr Minias, Ewa Pikus, Dariusz Anderwald   +2 more
doaj   +1 more source

Major histocompatibility complex in Osteichthyes

Journal of Veterinary Research, 2020
Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes.
Stosik Michał, Tokarz-Deptuła Beata, Deptuła Wiesław   +2 more
doaj   +1 more source

A novel HURRAH protocol reveals high numbers of monomorphic MHC class II loci and two asymmetric multi-locus haplotypes in the Père David's deer. [PDF]

PLoS ONE, 2011
The Père David's deer is a highly inbred, but recovered, species, making it interesting to consider their adaptive molecular evolution from an immunological perspective.
Qiu-Hong Wan, Pei Zhang, Xiao-Wei Ni, Hai-Long Wu, Yi-Yan Chen, Ye-Ye Kuang, Yun-Fa Ge, Sheng-Guo Fang   +7 more
doaj   +1 more source

Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus). [PDF]

, 2009
(c) 2009 Teacher et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
AA Cunningham, AA Cunningham, AL Hughes, Amber G. F. Teacher, AVS Hill, B Sammut, BC Clarke, BP Shum, D Posada, G Froeschke, GD Maniero, J Gantress, J Maynard Smith, J Robert, JM Seddon, JM Vyas, K Roelants, K Tamura, L Bernatchez, LF Jensen, M Nei, M Nonaka, M Ohtsuka, MA Beaumont, MF Flajnik, MF Flajnik, MF Flajnik, PC Doherty, PW Hedrick, R Frankham, RD Campbell, Richard A. Nichols, Robert DeSalle, S Berlin, S Conseguera, S Kumar, S Rozen, SB Piertney, T Antao, Trenton W. J. Garner, WE Briles, WF Bodmer, Y Ohta   +42 more
core   +12 more sources

MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen

Toxins, 2012
Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward ...
Judith A. James, A. Darise Farris, Melissa L. Nguyen, Philip M. Cox, Sherry R. Crowe, Eric K. Dumas, Sridevi Kurella, Jonathan J. Hunt, Lori Garman   +8 more
doaj   +1 more source

The Major Histocompatibility Complex of Old World Camels—A Synopsis

Cells, 2019
This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels.
Martin Plasil, Sofia Wijkmark, Jean Pierre Elbers, Jan Oppelt, Pamela Anna Burger, Petr Horin   +5 more
doaj   +1 more source

Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates

BMC Evolutionary Biology, 2013
BackgroundClassical major histocompatibility complex (MHC) class II molecules play an essential role in presenting peptide antigens to CD4+ T lymphocytes in the acquired immune system. The non-classical class II DM molecule, HLA-DM in the case of humans,
J. M. Dijkstra, U. Grimholt, Jong S Leong, B. Koop, K. Hashimoto   +4 more
semanticscholar   +1 more source