Results 11 to 20 of about 520,866 (339)
Cohesin Regulates MHC Class II Genes through Interactions with MHC Class II Insulators [PDF]
The Journal of Immunology, 2011 Abstract Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains.
Parimal Majumder, Jeremy M. Boss
openaire +4 more sources
BMC Evolutionary Biology, 2019 Background Genes of the Major Histocompatibility Complex (MHC) are essential for adaptive immune response in vertebrates, as they encode receptors that recognize peptides derived from the processing of intracellular (MHC class I) and extracellular (MHC ...
Piotr Minias +2 more
doaj +2 more sources
Mutation of RFXAP, a Regulator of MHC Class II Genes, in Primary MHC Class II Deficiency
New England Journal of Medicine, 1997 Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive primary immunodeficiency disease in which MHC class II molecules are absent. It is a genetically heterogeneous disease of gene regulation resulting from defects in several transactivating genes that regulate the expression of MHC class II genes.
Villard, Jean +5 more
openaire +5 more sources
The porcine Major Histocompatibility Complex and related paralogous regions: a review [PDF]
Genetics Selection Evolution, 2000 The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced.
Vaiman Marcel +3 more
doaj +7 more sources
Characterization of the major histocompatibility complex class II genes in miiuy croaker. [PDF]
PLoS ONE, 2011 Major histocompatibility complex (MHC) has a central role in the adaptive immune system by presenting foreign peptide to the T-cell receptor. In order to study the molecular function and genomic characteristic of class II genes in teleost, the full ...
Tianjun Xu +4 more
doaj +6 more sources
454 sequencing reveals extreme complexity of the class II Major Histocompatibility Complex in the collared flycatcher [PDF]
BMC Evolutionary Biology, 2010 Background Because of their functional significance, the Major Histocompatibility Complex (MHC) class I and II genes have been the subject of continuous interest in the fields of ecology, evolution and conservation. In some vertebrate groups MHC consists
Gustafsson Lars +5 more
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Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat. [PDF]
PLoS ONE, 2008 Two sequences of major histocompatibility complex (MHC) regions in the domestic cat, 2.976 and 0.362 Mbps, which were separated by an ancient chromosome break (55-80 MYA) and followed by a chromosomal inversion were annotated in detail.
Naoya Yuhki +4 more
doaj +6 more sources
F1000Research, 2016 Major histocompatibility complex (MHC) class II molecules present exogenously derived antigen peptides to CD4 T cells, driving activation of naïve T cells and supporting CD4-driven immune functions.
Jonathan Harton +3 more
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Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population [PDF]
Anais Brasileiros de Dermatologia, 2016 : Background: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic.
Ângela Marques Barbosa +7 more
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Frontiers in Cell and Developmental Biology, 2023 Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
Synne Arstad Bjørnestad +5 more
doaj +1 more source