Positional identification and functional analysis of genes regulating autoimmune arthritis [PDF]
, 2016 The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA).
Yau, Anthony Chun Yeung
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Frontiers in Immunology, 2021 Structures of peptide-loaded major histocompatibility complex class I (pMHC-I) and class II (pMHC-II) complexes are similar. However, whereas pMHC-II complexes include similar-sized IIα and IIβ chains, pMHC-I complexes include a heavy chain (HC) and a ...
Yanan Wu +4 more
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Selection and trans-species polymorphism of major histocompatibility complex class II genes in the order Crocodylia. [PDF]
PLoS ONE, 2014 Major Histocompatibility Complex (MHC) class II genes encode for molecules that aid in the presentation of antigens to helper T cells. MHC characterisation within and between major vertebrate taxa has shed light on the evolutionary mechanisms shaping the
Weerachai Jaratlerdsiri +4 more
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Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins [PDF]
, 2016 Indexación: Web of ScienceThe evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class I deals
Dantas, GPM +7 more
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PML promotes MHC class II gene expression by stabilizing the class II transactivator [PDF]
Journal of Cell Biology, 2012 Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ–induced MHC class II expression.
Ulbricht, Tobias +9 more
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Biology, 2016 Major histocompatibility complex (MHC) molecules are key players in initiating immune responses towards invading pathogens. Both MHC class I and class II genes are present in teleosts, and, using phylogenetic clustering, sequences from both classes have ...
Unni Grimholt
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Giant panda genomic data provide insight into the birth-and-death process of mammalian major histocompatibility complex class II genes. [PDF]
PLoS ONE, 2009 To gain an understanding of the genomic structure and evolutionary history of the giant panda major histocompatibility complex (MHC) genes, we determined a 636,503-bp nucleotide sequence spanning the MHC class II region.
Qiu-Hong Wan +4 more
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Functional Characterization of a Chicken Major Histocompatibility Complex Class II B Gene Promoter [PDF]
, 1997 A 0.7 kilobase (kb) DNA fragment from the 5\u27 flanking region of a chicken major histocompatibility complex (MHC) class II B gene was cloned into chloramphenicol acetyltransferase (CAT) reporter vectors and was transfected into a chicken macrophage ...
Carpenter, Susan +5 more
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Medicine, 2001 IntroductionPrimary human immunodeficiencies constitute a heterogenous group of inborn errors of the immune system due to a variety of genetic abnormalities. The study of patients with primary immunodeficiency diseases has expanded our understanding of immunity.
J, Villard +4 more
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Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.
PLoS ONE, 2014 The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation.
Weerachai Jaratlerdsiri +14 more
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