Results 21 to 30 of about 520,866 (339)
bioRxiv, 2022 CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on MHC-II molecules. The high polymorphism of MHC-II genes represents an important hurdle towards accurate prediction and identification ...
Julien Racle +14 more
semanticscholar +1 more source
Within-trio tests provide little support for post-copulatory selection on MHC haplotypes in a free-living population [PDF]
, 2021 Sexual selection has been proposed as a force that could help maintain the diversity of major histocompatibility complex (MHC) genes in vertebrates. Potential selective mechanisms can be divided into pre-copulatory and post-copulatory, and in both cases,
Huang, Wu, Pemberton, Josephine M
core +1 more source
MHC class I and II genes in Serpentes [PDF]
, 2020 AbstractGenes of the major class I and II histocompatibility complex have been extensively studied in mammals. Studies of these antigens in reptiles are very scarce. Here we describe the characteristics of these genes in the suborder Serpentes. We identified the presence of a much larger number of molecules of class I and beta chains of class II than ...
Serafin Mirete-Bachiller +2 more
openaire +2 more sources
BMC Genomics, 2020 Background The mammalian Major Histocompatibility Complex (MHC) is a genetic region containing highly polymorphic genes with immunological functions. MHC class I and class II genes encode antigen-presenting molecules expressed on the cell surface.
Marie Klumplerova +9 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2022 BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He +8 more
doaj +1 more source
BMC Evolutionary Biology, 2013 BackgroundClassical major histocompatibility complex (MHC) class II molecules play an essential role in presenting peptide antigens to CD4+ T lymphocytes in the acquired immune system. The non-classical class II DM molecule, HLA-DM in the case of humans,
J. M. Dijkstra +4 more
semanticscholar +1 more source
Major histocompatibility complex in Osteichthyes
Journal of Veterinary Research, 2020 Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes.
Stosik Michał +2 more
doaj +1 more source
A novel HURRAH protocol reveals high numbers of monomorphic MHC class II loci and two asymmetric multi-locus haplotypes in the Père David's deer. [PDF]
PLoS ONE, 2011 The Père David's deer is a highly inbred, but recovered, species, making it interesting to consider their adaptive molecular evolution from an immunological perspective.
Qiu-Hong Wan +7 more
doaj +1 more source
Modulation of Gene Expression by the MHC Class II Transactivator [PDF]
The Journal of Immunology, 2002 Abstract The class II transactivator (CIITA) is a master regulator of MHC class II expression. CIITA also modulates the expression of MHC class I genes, suggesting that it may have a more global role in gene expression. To determine whether CIITA regulates genes other than the MHC class II and I family, DNA microarray analysis was used ...
Alyssa Bushey +2 more
openaire +3 more sources
Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression [PDF]
, 1996 CIITA activates the expression of multiple genes involved in antigen presentation and it is believed to be required for both constitutive and IFN\xce\xb3-inducible expression of these genes.
Chang, C.-H. (Cheong-Hee) +4 more
core +1 more source