Integrative genomic and immunoinformatic approach for characterizing HIV-1 pol, vpr, and Nef genes and designing a multi-epitope vaccine [PDF]
Scientific ReportsThe study aims to characterize the Pol, Vpr, and Nef genes, as well as to explore the development of vaccines using computational tools. In this study, blood was extracted from HIV-positive samples, followed by RNA extraction.
Akmal Zubair +3 more
doaj +2 more sources
Simultaneous efficacy of IL-15 and the HSP70 fragments in increasing immunostimulatory effects of a HIV-1 DNA vaccine candidate against SCR HIV-1. [PDF]
PLoS ONEInterleukin (IL)-15 serves as a potent adjuvant that can enhance T cell-directed vaccine responses. Moreover, heat shock proteins (HSPs) have been used as potent adjuvants in immunotherapy of tumors and infectious diseases, as well as in vaccine ...
Mehrshad Fekri +3 more
doaj +2 more sources
Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction [PDF]
Infectious Disease ReportsBackground: Human Immunodeficiency Virus (HIV) infections remain a source of cardiopulmonary complications among people receiving antiretroviral therapy.
Amanda K. Garcia +9 more
doaj +2 more sources
The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women [PDF]
Journal of VirologyHIV-1 Nef mediates immune evasion and viral pathogenesis in part through the downregulation of cell surface cluster of differentiation 4 (CD4) and major histocompatibility complex class I (MHC-I) on infected cells.
Sherazaan D. Ismail +13 more
doaj +2 more sources
Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]
, 2013 G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
Frasson, Ilaria +8 more
core +11 more sources
Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. [PDF]
PLoS ONE, 2012 HIV-1 Nef protein contributes essentially to the pathology of AIDS by a variety of protein-protein-interactions within the host cell. The versatile functionality of Nef is partially attributed to different conformational states and posttranslational ...
Ellen C Kammula +5 more
doaj +1 more source
A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef. [PDF]
PLoS ONE, 2015 The HIV-1-encoded protein, Nef, plays a key role in the development of AIDS. One of Nef's functions is to keep MHC class I off the surface of infected cells, a process that requires the host proteins clathrin and AP-1. To identify other proteins involved
Maja K Choma +3 more
doaj +1 more source
Infectious Agents and Cancer, 2020 Background Non-Hodgkin lymphoma is of high prevalence among HIV-infected people. In particular, the incidence of HIV-associated Burkitt lymphoma (BL) remains high despite the advent of Highly Active Anti-Retroviral Therapy.
Nontlantla Mdletshe +3 more
doaj +1 more source
Frontiers in Immunology, 2022 A series of HIV-1 CRF01_AE/CRF07_BC recombinants were previously found to have emerged gradually in a superinfected patient (patient LNA819). However, the extent to which T-cell responses influenced the development of these recombinants after ...
Hui Zhang +30 more
doaj +1 more source
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. [PDF]
PLoS Pathogens, 2007 Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways.
Zabrina L Brumme +16 more
doaj +1 more source