Results 91 to 100 of about 26,095 (198)

Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

Retrovirology, 2007
Background The Sydney blood bank cohort (SBBC) of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1).
Wesselingh Steven L, Chiavaroli Lisa, Churchill Melissa J, Gorry Paul R   +3 more
doaj   +1 more source

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

Advanced Science, Volume 12, Issue 45, December 4, 2025.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato, June Ho Hwang, Manolo U. Rios, Nicole E. Familiari, Michael K. Rosen, Jeffrey B. Woodruff   +5 more
wiley   +1 more source

Simian immunodeficiency virus Nef gene regulates the production of 2-LTR circles in vivo

Virology, 2003
The replication dynamics of simian immunodeficiency virus (SIVmac32H-C8), attenuated through discrete genetic disruption of the nef gene, were compared with the wild-type parental clone (SIVmac32H-J5) using quantitative molecular methods. The primary viraemia of both infections were similar during the first week, but peaked on Day 10 at higher levels ...
Clarke, S, Almond, N, Berry, N
openaire   +2 more sources

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2012
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Bower, Mark, Gazzard, Brian G, Goodier, Martin R, Gregson, John NS, Kuri-Cervantes, Leticia, Mela, Christopher M   +5 more
core   +1 more source

Brain‐Wide Connectivity Patterns of Feedforward and Feedback Cortico‐Cortical Neurons in the Mouse Secondary Visual Cortex

Journal of Comparative Neurology, Volume 533, Issue 12, December 2025.
Using projection‐ and layer‐specific rabies tracing, we mapped brain‐wide inputs to multiple feedforward and feedback neuron types in VISl (LM), the mouse secondary visual cortex. Although input patterns were broadly similar across neuron types, we observed differences in the relative contributions of visual, retrosplenial, and auditory cortices ...
Richard G. Dickson, Matthew W. Jacobs, John M. Ratliff, Alec L. R. Soronow, Faye An, Walid A. Yuqob, Euiseok J. Kim   +6 more
wiley   +1 more source

Evidence for Adaptive Evolution at the Divergence Between Lymphoid and Brain HIV-1nefGenes [PDF]

AIDS Research and Human Retroviruses, 2010
Human immunodeficiency virus type 1 (HIV) infection of the central nervous system frequently causes HIV-associated neurocognitive disorders (HAND). The role of HIV Nef and other accessory proteins in HAND pathogenesis is unclear. To determine whether HIV nef undergoes adaptive selection in brain, we cloned 100 nef sequences (n = 30 brain and n = 70 ...
Kevin C, Olivieri, Kristin A, Agopian, Joya, Mukerji, Dana, Gabuzda   +3 more
openaire   +2 more sources

Host restriction factors in retroviral infection: promises in virus-host interaction

Retrovirology, 2012
Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-host interactions. Among retroviruses, the primate lentiviruses have one of the more complex genome structures with three categories of viral genes ...
Zheng Yong-Hui, Jeang Kuan-Teh, Tokunaga Kenzo   +2 more
doaj   +1 more source

Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection [PDF]

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
ANDREW J. McMICHAEL, ANNE EDWARDS, BARBARA MORGAN, Culmann B, Johnson RP, KARL McINTYRE, McMichael AJ, MIKE BUNCE, PAUL GIANGRANDE, PETER KRAUSA, PHILIP J.R. GOULDER, RODNEY E. PHILLIPS, SIOBHAN CROWLEY   +12 more
core   +2 more sources

Deciphering epigenetic regulation in postmenopausal osteoporosis: Current and future perspectives

VIEW, Volume 6, Issue 6, December 2025.
In this perspective, the significant roles of microRNAs, long noncoding RNAs and circular RNAs in postmenopausal osteoporosis are thoroughly expounded. The advantages and limitations of typical noncoding RNAs as diagnostic biomarkers and therapeutic targets are summarized and discussed.
Xiumei Tang, Meiru Chen, Guixuan Xu, Yuan Li, Sen Guo, Yufeng Huang, Zhaoliang Hou, Xiaoling Hou, Zhijian Wei, Wenzhao Wang, Bing Ning   +10 more
wiley   +1 more source

Functional association between the nef gene product and gag‐pol region of HIV‐1

FEBS Letters, 2000
Nef gene function is diverse among virus isolates of primate immunodeficiency viruses. We found differential effects of nef mutation on the virus replication between two HIV‐1 clones, NL432 and LAI. The nef mutation in NL432 affected the infectivity more severely compared with that in LAI, although the Nef functions of both clones were comparable ...
Ono, Takeshi, Iwatani, Yasumasa, Nishimura, Akiko, Ishimoto, Akinori, Sakai, Hiroyuki   +4 more
openaire   +2 more sources