Results 111 to 120 of about 26,095 (198)

Computational analysis of HIV-1 resistance based on gene expression profiles and the virus-host interaction network.

PLoS ONE, 2011
A very small proportion of people remain negative for HIV infection after repeated HIV-1 viral exposure, which is called HIV-1 resistance. Understanding the mechanism of HIV-1 resistance is important for the development of HIV-1 vaccines and Acquired ...
Tao Huang, Zhongping Xu, Lei Chen, Yu-Dong Cai, Xiangyin Kong   +4 more
doaj   +1 more source

Characterization of transgene expression in adenoviral vector-based HIV-1 vaccine candidates

Virology Journal, 2010
Recombinant adenovirus vectors have been extensively used in gene therapy clinical studies. More recently, the capability of inducing potent cell-mediated and humoral immunity has made these vectors equally attractive candidates for prophylactic or ...
Rolling Judith A, Takahashi Marie-Noëlle, Owen Katherine E   +2 more
doaj   +1 more source

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

Retrovirology, 2007
In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying major deletions in nef and other accessory genes.
Wesselingh Steven L, Dyer Wayne B, Verity Erin, McPhee Dale A, Gorry Paul R, Learmont Jennifer, Sullivan John S, Roche Michael, Zaunders John J, Gabuzda Dana, Crowe Suzanne M, Mills John, Lewin Sharon R, Brew Bruce J, Cunningham Anthony L, Churchill Melissa J   +15 more
doaj   +1 more source

A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.

PLoS ONE, 2011
The vaccinia virus (VACV) C6 protein has sequence similarities with the poxvirus family Pox_A46, involved in regulation of host immune responses, but its role is unknown.
Juan García-Arriaza, José Luis Nájera, Carmen E Gómez, Nolawit Tewabe, Carlos Oscar S Sorzano, Thierry Calandra, Thierry Roger, Mariano Esteban   +7 more
doaj   +1 more source

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses. [PDF]

, 2019
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays.
Antar, Annukka AR, Beg, Subul A, Bender, Alexandra M, Bertagnolli, Lynn N, Blankson, Joel N, Bruner, Katherine M, Bushman, Frederic D, Capoferri, Adam A, Deeks, Steven G, Fray, Emily J, Gregg, John, Ho, Ya-Chi, Jenike, Katharine M, Kufera, Joshua T, Kwon, Kyungyoon J, Laird, Gregory M, Margolick, Joseph B, Nobles, Christopher, Sengupta, Srona, Siliciano, Janet D, Siliciano, Robert F, Simonetti, Francesco R, Timmons, Andrew, Wada, Nikolas, Wang, Zheng, Zhang, Hao   +25 more
core   +1 more source

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

Nature Communications
Innate antiviral factors are essential for effective defense against viral pathogens. However, the identity of major restriction mechanisms remains elusive.
Caterina Prelli Bozzo, Alexandre Laliberté, Aurora De Luna, Chiara Pastorio, Kerstin Regensburger, Stefan Krebs, Alexander Graf, Helmut Blum, Meta Volcic, Konstantin M. J. Sparrer, Frank Kirchhoff   +10 more
doaj   +1 more source

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors.

PLoS ONE, 2011
Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans.
Esther D Quakkelaar, Anke Redeker, Elias K Haddad, Alexandre Harari, Stella Mayo McCaughey, Thomas Duhen, Abdelali Filali-Mouhim, Jean-Philippe Goulet, Nikki M Loof, Ferry Ossendorp, Beatriz Perdiguero, Paul Heinen, Carmen E Gomez, Karen V Kibler, David M Koelle, Rafick P Sékaly, Federica Sallusto, Antonio Lanzavecchia, Giuseppe Pantaleo, Mariano Esteban, Jim Tartaglia, Bertram L Jacobs, Cornelis J M Melief   +22 more
doaj   +1 more source

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir. [PDF]

, 2018
Unbiased shRNA library screens revealed that the estrogen receptor-1 (ESR-1) is a key factor regulating HIV-1 latency. In both Jurkat T cells and a Th17 primary cell model for HIV-1 latency, selective estrogen receptor modulators (SERMs, i.e ...
Bacchetti, Peter, Chomont, Nicolas, Das, Biswajit, Deeks, Steven G, Dobrowolski, Curtis, Gandhi, Monica, Hoh, Rebecca, Johnston, Rowena, Karn, Jonathan, Luttge, Benjamin, Scully, Eileen, Valadkhan, Saba   +11 more
core  

A study of the HIV-1 regulatory genes using the polymerase chain reaction

Вопросы вирусологии, 2015
In this work, a total of 200 samples from the HIV-infected individuals were analyzed: 50 samples from the Saha Republic (Yakutia), 50 samples from the Vologda Region (City of Cherepovets), and 100 samples from the Moscow Region (Moscow and Moscow Region).
K. A. Ryzhov, M. N. Nosik, A. V. Kravtchenko   +2 more
doaj  

Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle

Viruses, 2017
Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1).
Olivier Leymarie, Leslie Lepont, Clarisse Berlioz-Torrent   +2 more
doaj   +1 more source