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Results 121 to 130 of about 26,095 (198)

Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy

Malaria Journal, 2010
Background This study was performed to better understand the genetic diversity of known polymorphisms in pfatpase6 and pfmdr1 genes before the introduction of ACT in Brazil, in order to get a genotypic snapshot of Plasmodium falciparum parasites that may
Rosenthal Philip J +8 more
doaj +1 more source

Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates

Virus Genes, 2019
Almost 80% of viral transcripts during early HIV-1 infection encode the Nef protein, which has been implicated in altering expression of a number of genes. In this study, we infected primary human CD4+ T cells with pseudotyped Nef-containing or Nef-deleted (Δ-nef) NL4-3 virus and used RNA-Sequencing (RNA-Seq) for transcriptomic analysis.
Robert L. Furler +3 more
openaire +5 more sources

microRNA-422a promotes HIV replication and innate immune evasion by targeting MECP2

Molecular Therapy: Nucleic Acids
Understanding the mechanisms underlying interferon-alpha (IFNα) anti-human immunodeficiency virus type I (HIV-1) effects and HIV-1 innate immune evasion is critical to developing improved antiviral strategies.
Li Du +8 more
doaj +1 more source

Role of nef in HIV-1 gene regulation

, 1992
Doctorat en ...
openaire +1 more source

Opinion: Inhibition of Blood-Brain Barrier Repair as a Mechanism in HIV-1 Disease. [PDF]