Results 11 to 20 of about 26,095 (198)
Journal of Ginseng Research, 2017 Background: The presence of gross deletions in the human immunodeficiency virus nef gene (gΔnef) is associated with long-term nonprogression of infected patients.
Young-Keol Cho +2 more
doaj +3 more sources
Single Genome Sequencing of Expressed and Proviral HIV-1 Envelope Glycoprotein 120 (gp120) and nef Genes [PDF]
Bio-Protocol, 2017 The current study provides detailed protocols utilized to amplify the complete HIV-1 gp120 and nef genes from single copies of expressed or integrated HIV present in fresh-frozen autopsy tissues of patients who died while on combined antiretroviral ...
David Nolan +5 more
doaj +5 more sources
The nef gene of simian immunodeficiency virus SIVmac1A11 [PDF]
Journal of Virology, 1992 The role of the simian immunodeficiency virus (SIV) nef gene in viral replication was investigated in several tissue culture systems. SIVmac1A11 is a molecularly cloned virus which replicates in both peripheral blood mononuclear cells (PBMC) and macrophages, although no disease is observed in infected rhesus macaques.
R E, Unger +4 more
openaire +2 more sources
Mutational analysis of the simian immunodeficiency virus SIVmac nef gene [PDF]
Journal of Virology, 1991 We are using site-directed mutagenesis of single viral genes to identify and analyze the genetic determinants of human and simian immunodeficiency virus pathogenicity. In a first approach, we have constructed a series of simian immunodeficiency virus SIVmac nef mutants by partial deletion and insertions in the nef gene, as this gene is a candidate gene
D, Binninger +4 more
openaire +2 more sources
Glomerulosclerosis and viral gene expression in HIV-transgenic mice: Role of nef [PDF]
Kidney International, 2000 Human immunodeficiency virus (HIV)-associated nephropathy is characterized by focal segmental glomerulosclerosis and microcystic tubular dilation. We have previously described a mouse transgenic for a Deltagag-pol HIV-1 genome, which develops glomerulosclerosis, cutaneous papillomas, and cataracts.We developed mice transgenic for a Deltagag-pol-nef HIV
Kajiyama, Wataru +4 more
openaire +2 more sources
Genealogical Evidence for Positive Selection in the nef Gene of HIV-1 [PDF]
Genetics, 1999 AbstractThe pattern and process of evolution in the nef gene of HIV-1 was analyzed within and among patients. Using a maximum likelihood method that allows for variable intensity of selection pressure among codons, strong positive selection was detected in a hemophiliac patient over 30 mo of infection.
P M, Zanotto +3 more
openaire +2 more sources
Retrovirology, 2008 AIDS-associated, CCR5-tropic (R5) HIV-1 clones, isolated from a patient that never developed CXCR4-tropic HIV-1, replicate to a greater extent and cause greater cytopathic effects than R5 HIV-1 clones isolated before the onset of AIDS.
Rekosh David +7 more
doaj +1 more source
Kaohsiung Journal of Medical Sciences, 2021 Osteoporosis is characterized by osteopenia and bone tissue microstructure degradation. Adipose‐derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells and have the potential to undergo ...
Ying Ming, Zheng‐Peng Liu
doaj +1 more source
The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation [PDF]
, 2009 Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence indicates that an important component of the persistence strategy involves active interference with
AB Rickinson +81 more
core +12 more sources
Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]
, 2019 HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D +4 more
core +3 more sources