Results 31 to 40 of about 26,095 (198)

Effects of HIV-1 nef on cellular gene expression profiles

Journal of Biomedical Science, 2002
The early human immunodeficiency virus (HIV) accessory protein Nef makes an important contribution to virulence, but the mechanisms by which Nef influences pathogenesis remain unclear. Many well-studied effects of Nef, like CD4 and class I MHC downregulation, occur posttranslationally.
Syed, Shaheduzzaman, Vyjayanthi, Krishnan, Ana, Petrovic, Michael, Bittner, Paul, Meltzer, Jeffrey, Trent, Sundararajan, Venkatesan, Steven, Zeichner   +7 more
openaire   +2 more sources

Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control

Retrovirology, 2018
Background Despite the low level of viral replication in HIV controllers (HICs), studies have reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in HIV-1 plasma sequences.
Diogo Gama Caetano, Fernanda Heloise Côrtes, Gonzalo Bello, Sylvia Lopes Maia Teixeira, Brenda Hoagland, Beatriz Grinsztejn, Valdilea Gonçalves Veloso, Monick Lindenmeyer Guimarães, Mariza Gonçalves Morgado   +8 more
doaj   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source

Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1? [PDF]

, 2016
ncreasing lines of evidence indicate that NKG2D, an activating receptor of natural killer (NK) and CD8(+) T cells, plays an important role in immune responses against HIV-1. Through its ability to recognize a diverse array of ligands (NKG2DLs) induced by
Cerboni, Cristina, Doria, Margherita, Giuliani, Rica, Vassena, Lia   +3 more
core   +1 more source

Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity [PDF]

, 2011
Human immunodeficiency virus type 1 (HIV-1) Tat plays an important role in HIV-associated neuropathogenesis; the underlying mechanisms are still evolving. We have recently shown that HIV-1 Tat induces expression of glial fibrillary acidic protein (GFAP),
Fan, Yan, Green, Linden A., He, Johnny J., oh Kim, Byung, Zou, Wei   +4 more
core   +1 more source

Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo [PDF]

Journal of Virology, 1993
The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain. As an attempt to elucidate the function of nef, we characterized the nucleotide and corresponding protein sequences of ...
D C, Shugars, M S, Smith, D H, Glueck, P V, Nantermet, F, Seillier-Moiseiwitsch, R, Swanstrom   +5 more
openaire   +2 more sources

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

Cell Reports, 2015
NF-κB is essential for effective transcription of primate lentiviral genomes and also activates antiviral host genes. Here, we show that the early protein Nef of most primate lentiviruses enhances NF-κB activation.
Daniel Sauter, Dominik Hotter, Benoît Van Driessche, Christina M. Stürzel, Silvia F. Kluge, Steffen Wildum, Hangxing Yu, Bernd Baumann, Thomas Wirth, Jean-Christophe Plantier, Marie Leoz, Beatrice H. Hahn, Carine Van Lint, Frank Kirchhoff   +13 more
doaj   +1 more source

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]

, 2018
G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core   +1 more source

Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product [PDF]

Journal of Virology, 1990
nef genes from human immunodeficiency virus type 1 isolates BH10 and LAV1 (lymphadenopathy-associated virus type 1) were expressed in Escherichia coli under the deo operon promoter. The two proteins found in the soluble compartment of the bacterial lysate were purified by ion-exchange column chromatography to apparent homogeneity.
J, Kaminchik, N, Bashan, D, Pinchasi, B, Amit, N, Sarver, M I, Johnston, M, Fischer, Z, Yavin, M, Gorecki, A, Panet   +9 more
openaire   +2 more sources

Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design

Memorias do Instituto Oswaldo Cruz, 2002
Most of the Brazilian HIV-1 samples have been characterized based on the structural genes (env, gag and pol) and no data concerning the variability of the accessory genes such as nef have been available so far.
ML Guimarães, AS Moreira, MG Morgado
doaj   +1 more source