Simian immunodeficiency virus infection in wild-caught chimpanzees from Cameroon [PDF]
, 2005 Simian immunodeficiency viruses (SIVcpz) infecting chimpanzees (Pan troglodytes) in west central Africa are the closest relatives to all major variants of human immunodeficiency virus type 1 ([HIV-1]; groups M, N and O), and have thus been implicated as ...
Ayouba, A +12 more
core +2 more sources
Expression, purification and biochemical characterisation of the human immunodificiency virus 1 nef gene product [PDF]
European Journal of Biochemistry, 1992 The human immunodeficiency virus 1 (HIV‐1) nef gene encoded by the HIV‐1 isolate lymphadenopathy‐associated virus type 1 was expressed in Escherichia coli under the control of the tac promoter. The protein is found mainly in the soluble part of the bacterial lysate; a simple twocolumn purification scheme has been developed allowing isolation of the ...
Wolber, V. +6 more
openaire +4 more sources
Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]
, 2019 HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda +15 more
core +3 more sources
Triggers for atrial fibrillation. the role of anxiety [PDF]
, 2019 Atrial fibrillation (AF) is the most widely recognized arrhythmia. Systemic arterial hypertension, diabetes, obesity, heart failure, and valvular heart diseases are major risk factors for the onset and progression of AF.
Ceccacci, Andrea +10 more
core +1 more source
nef gene sequence variation among HIV‐1‐infected African children*
HIV Medicine, 2006 BackgroundThere are few data on African children infected with nonclade B HIV‐1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV‐1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in ...
Chakraborty, R +11 more
openaire +3 more sources
HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi's Sarcoma during AIDS. [PDF]
, 2016 Kaposi's sarcoma (KS) in HIV-infected individuals can have a wide range of clinical outcomes, from indolent skin tumors to a life-threatening visceral cancer. KS tumors contain endothelial-related cells and inflammatory cells that may be HIV-infected. In
Barbier, Andrew E +6 more
core +4 more sources
The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells
Vaccine Research, 2020 Introduction: Vaccine design is mainly considered as a therapeutic strategy to elicit HIV-specific immunity. DNA vaccines encoding an antigen and also an adjuvant can induce an effective adaptive immunity. Due to having numerous roles in viral infection,
Alireza Milani +3 more
doaj
Evolution of the HIV-1
Retrovirology, 2010 Elite controllers or suppressors (ES) are HIV-1 infected patients who maintain viral loads of < 50 copies/ml without antiretroviral therapy. CD8+ T cells are thought to play a key role in the control of viral replication and exert selective pressure on ...
Siliciano Robert F +6 more
doaj +1 more source
HIV-1-related factors interact with p53 to influence cellular processes
AIDS Research and Therapy, 2023 Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif).
Shanling Liu +5 more
doaj +1 more source
In-vivo mutation rates and fitness landscape of HIV-1
, 2016 Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we
Albert, Jan +4 more
core +1 more source