BMC Genomics, 2017 Background Mouse fetuses up to 16\ua0day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin healing. The expression of transcription factor Foxn1 in the epidermis
Kopcewicz, Marta +5 more
core +3 more sources
Analysis of Pathogenesis of Autoimmune Insulitis in NOD Mice: Adoptive Transfer Experiments of Insulitis in ILI and NOD Nude Mice [PDF]
Experimental animals, 1996 In an effort to study the pathophysiological events in the development of insulitis in NOD mice, we have developed ILI- and NOD-nu/nu mice. ILI mice are a nondiabetic inbred strain but are derived from the same Jcl:ICR mouse as NOD mice and share the ...
Nakamura, Moritaka +3 more
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Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis [PDF]
American Journal of Human Genetics, 2019 FOXN1 is the master regulatory gene of thymic epithelium development. FOXN1 deficiency leads to thymic aplasia, alopecia, and nail dystrophy, accounting for the nude/severe combined immunodeficiency (nu/SCID) phenotype in humans and mice.
Claudio Pignata +74 more
core +2 more sources
New method for detecting cellular transforming genes.
Science, 1982 Tumor induction in athymic nude mice can be used to detect dominant transforming genes in cellular DNA. Mouse NIH 3T3 cells freshly transfected with either cloned Moloney sarcoma proviral DNA or cellular DNA's derived from virally transformed cells ...
Eader, L. A. +9 more
core +2 more sources
The role of the transcription factor Foxn1 in Thymus organogenesis and maintenance [PDF]
, 2014 The thymus is the primary lymphoid organ responsible for T-cell development and selection, which requires a specialised stromal microenvironment. The thymic stroma consists mainly of thymic epithelial cells (TEC), which can be divided into cortical (c ...
Bosch, Angela Jeanne Tamara
core +1 more source
OncoTarget, 2016 Abnormal expression of the clock gene PER1 is highly correlated with carcinogenesis and the development of malignant tumors. Here, we designed short hairpin RNAs (shRNAs) to effectively knock down PER1 in SCC15 human oral squamous cell carcinoma cells ...
Han-xue Li +5 more
semanticscholar +1 more source
Frequent Establishment of Long-term-cultured Myofibroblast Cell Lines Derived from Dupuytren’s Nodules, Which Are Implantable into Nude Mice [PDF]
, 2007 The purpose of this study is to establish myofibroblast cell lines derived from Dupuytren’s nodules. Cells were obtained from 6 patients with Dupuytren’s contracture, and those from 4 out of the 6 patients were serially passaged.
ABE, Muneaki +19 more
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Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice [PDF]
, 2011 Background We have shown that insertion of the three vaccinia virus (VACV) promoter-driven foreign gene expression cassettes encoding Renilla luciferase-Aequorea GFP fusion protein, β-galactosidase, and β-glucuronidase into the F14.5L, J2R, and A56R loci
Nanhai G Chen +11 more
core +1 more source
Journal of Experimental Medicine, 1987 The expression of T cell antigen receptors (TCR) in congenitally athymic (nude) mice has been investigated. Lymph node T cells from 4-5- mo-old athymic mice expressed full-length transcripts for the TCR alpha and beta chains at a level two-to three-fold ...
H. Macdonald +4 more
semanticscholar +1 more source
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]
, 2007 Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Millar, J.K. +14 more
core +1 more source