Results 21 to 30 of about 17,032 (179)
World Journal of Gastroenterology, 2004 AIM To establish a nude mice model of human hepatocellular carcinoma (HCC) via orthotopic implantation of histologically intact tissue, in order to study biologic features of HCC in vivo and to direct clinical treatment respectively.
Yong Gao +3 more
semanticscholar +1 more source
Transforming growth factor-β signaling in thymic epithelial cells : its role in development, steady-state and immune reconstitution [PDF]
, 2010 The thymus constitutes the primary lymphoid organ responsible for the generation of naïve T cells. Its stromal compartment is composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for ...
Hauri-Hohl, Mathias Martin
core +1 more source
, 1987 The expression and sequences of T cell antigen receptor (TcR) α and β‐chain genes were investigated in the spleens from congenitally athymic (nude) mice.
Yoshikai, Yasunobu +4 more
core +1 more source
In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system
, 2006 We have used the tetracycline (tet)-regulated system as described previously to evaluate the applicability of controlled gene expression in cancer gene therapy. As a model gene, we used the human interleukin-2 (IL-2) gene, which has been placed under the
Wirth, Thomas +4 more
core +1 more source
In vitro studies on T cell proliferation and Lymphokine factor production in the amphibian, Xenopus [PDF]
, 1990 The major aim of this Thesis has been to procure and begin to characterise T cell-derived cytokines in the clawed toad, Xenopus. Recent reports have suggested that Xenopus lymphocytes, stimulated in vitro with T cell mitogens, will generate factors that ...
Turner, Sarah Louise
core
, 2017 The objective of this study is to study the late-chronic effects of fractionated whole brain irradiation (fWBI) on cognitive impairment and associated cellular and molecular neuro-inflammatory mechanisms using clinically relevant and reliable mouse ...
Saikh Haque +8 more
core +1 more source
Advanced Science, EarlyView.This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao +5 more
wiley +1 more source
Combined Inhibition of FOSL-1 and YAP Using siRNA-Lipoplexes Reduces the Growth of Pancreatic Tumor [PDF]
, 2022 SIMPLE SUMMARY: Intercepting the molecular mechanisms implicated in pancreatic cancer progression can be an efficient therapeutic approach to treat this aggressive tumor. The Hippo pathway is a key mechanism driving tumor progression, even in the absence
Ana Igea +27 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo +16 more
wiley +1 more source
, 2014 Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities.
Soheil S Dadras +17 more
core +1 more source