Results 31 to 40 of about 16,086 (104)

RAS Inhibitor RMC‐7977 Blocks Vascular Overgrowth of NRASQ61R Mutant Endothelial Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT RAS mutations occur in patients with several types of vascular anomalies, but effective treatments remain limited. To address this need, we evaluated the RAS (ON) multi‐selective inhibitor RMC‐7977 in human endothelial cells (ECs) expressing the NRASQ61R mutation found in kaposiform lymphangiomatosis (KLA).
Sara Alharbi, Svatava Merkle, Patricia Pastura, C. Griffin McDaniel, George S. Zaky, Andrew M. Waters, Timothy D. Le Cras   +6 more
wiley   +1 more source

Unveiling the New Trick for Epigenetic Drug: Radiation Enhancement of Prostate Cancer by the EZH2 Inhibitor Tazemetostat

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT The enhancer of zeste homologue 2 inhibitor (EZH2i) Tazemetostat (EPZ‐6438) has demonstrated antitumour efficacy in various malignancies. This study aims to evaluate its radiosensitising potential and underlying mechanisms in prostate cancer (PCa). In vitro functional assays, including wound healing, Transwell invasion, EdU proliferation, flow
Tian‐Qi Du, Yuhong Ou, Rui‐Ji Liu, Yi Feng, Yaxun Li, Gang Chen, Xingyu Wu   +6 more
wiley   +1 more source

Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart

The Journal of Physiology, Volume 604, Issue 15, Page 6281-6301, 1 August 2026.
Abstract figure legend The β1‐adrenergic receptor is the predominant adrenergic subtype expressed on cardiac myocytes. Upon stimulation it activates downstream signalling pathways that increase the heart rate and cardiac output to meet metabolic demands.
Parham Diba, Peter R. Levasseur, Samuel D. Newton, Khia Min Sabrina Koh, Paige C. Arneson‐Wissink, Xinxia Zhu, Peter Pham, Heike Mendez, Luke Whitcomb, Ariana Sattler, William R Woodward, Beth A. Habecker, Daniel L. Marks, Aaron J. Grossberg   +13 more
wiley   +1 more source

Ligature-induced periodontitis in mice potentially accelerates CD4⁺ T-cell senescence and exacerbates rheumatoid arthritis. [PDF]

Front Immunol
Li J, Sanui T, Shida M, Yotsumoto K, Ahmad M, Wang Z, Xiao M, Hayashi C, Shinjo T, Taketomi T, Fukuda T, Nishimura F.   +11 more
europepmc   +1 more source

ZNF217 promotes ovarian cancer progression by impacting multiple pivotal steps in the metastatic process. [PDF]

NPJ Precis Oncol
Wardrup KC, Hoffman J, Pandya MJ, Navarathna N, Tulapurkar ME, Padmanabhan A.   +5 more
europepmc   +1 more source

A Comprehensive Review of <i>Hedyotis Diffusa</i> Willd-<i>Scutellaria Barbata</i> D. Don Herb Pair in Anti- Hepatocellular Carcinoma Effects and Their Combinatorial Effects and Mechanisms. [PDF]

Drug Des Devel Ther
Xu Y, Xiang W, Zhu W, Shang L, Lun M, Qu S, Yin Y, Chen C, Yuan H, Song Y.   +9 more
europepmc   +1 more source

Screening of Low-Tumorigenic MDCK Cells for Potential Influenza Vaccine Substrates and Transcriptomic Analyses. [PDF]

Int J Mol Sci
Zhou L, Li X, Chen J, Liu Y, Zhang Y, Gong X, Meng Q, Li Z.   +7 more
europepmc   +1 more source

A novel hairless highly immunodeficient mice model optimized for in vivo imaging. [PDF]

Lab Anim Res
Matsuda K, Kariya R, Fujikawa S, Maeda K, Okada S.   +4 more
europepmc   +1 more source

The Crosstalk Between Epithelial-Mesenchymal Transition and Anoikis Resistance: A New Perspective of Traditional Chinese Medicine to Prevent Tumor Metastasis. [PDF]

Drug Des Devel Ther
Cui Z, Xu M, Liu J, Zhang K, Huang B.
europepmc   +1 more source

Potential roles of plant metabolites and Traditional Chinese Medicine formulas in regulating glycolysis-OXPHOS plasticity in gastric precancerous lesions and gastric cancer: a critical appraisal of the evidence. [PDF]

Front Pharmacol
Li S, Ma J, Ma C, Song Y, Chang L, Huo B.   +5 more
europepmc   +1 more source