Results 21 to 30 of about 12,042,101 (283)

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

open access: yesNature Communications, 2020
Chronic lung diseases are characterized by molecular and cellular composition changes. Here the authors use single-cell RNA sequencing to map cell type-specific changes in human tracheal epithelium related to smoking, and to provide evidence for a tuft ...
Katherine C. Goldfarbmuren   +11 more
doaj   +1 more source

Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets

open access: yesCancer Research, 2004
Accurate normalization is an absolute prerequisite for correct measurement of gene expression. For quantitative real-time reverse transcription-PCR (RT-PCR), the most commonly used normalization strategy involves standardization to a single ...
C. Andersen, J. L. Jensen, T. Ørntoft
semanticscholar   +1 more source

RNAmmer: consistent and rapid annotation of ribosomal RNA genes

open access: yesNucleic Acids Research, 2007
The publication of a complete genome sequence is usually accompanied by annotations of its genes. In contrast to protein coding genes, genes for ribosomal RNA (rRNA) are often poorly or inconsistently annotated.
K. Lagesen   +5 more
semanticscholar   +1 more source

SLC38A6 expression in macrophages exacerbates pulmonary inflammation

open access: yesRespiratory Research, 2023
Pulmonary inflammation involves complex changes of the immune cells, in which macrophages play important roles and their function might be influenced by metabolism. Slc38a6 acts as a carrier of nutrient for macrophages (Mφ) to exert the function. In this
Yizhao Peng   +10 more
doaj   +1 more source

Generation and Characterization of a Zebrafish Model for ADGRV1-Associated Retinal Dysfunction Using CRISPR/Cas9 Genome Editing Technology

open access: yesCells, 2023
Worldwide, around 40,000 people progressively lose their eyesight as a consequence of retinitis pigmentosa (RP) caused by pathogenic variants in the ADGRV1 gene, for which currently no treatment options exist.
Merel Stemerdink   +5 more
doaj   +1 more source

The Epidermis: Genes On – Genes Off

open access: yesJournal of Investigative Dermatology, 1997
The epidermal keratinocyte stem cell is distinguished by a relatively undifferentiated phenotype and an ability to proliferate. As part of a carefully orchestrated process, the offspring of these stem cells lose the ability to proliferate and begin a process of morphologic and biochemical transformation that results in their conversion into corneocytes.
Richard L. Eckert   +3 more
openaire   +3 more sources

Genotype-Phenotype Correlations of Pathogenic COCH Variants in DFNA9: A HuGE Systematic Review and Audiometric Meta-Analysis

open access: yesBiomolecules, 2022
Pathogenic missense variants in COCH are associated with DFNA9, an autosomal dominantly inherited type of progressive sensorineural hearing loss with or without vestibular dysfunction.
Sybren M. M. Robijn   +9 more
doaj   +1 more source

Light-matter interactions in multi-element resonators

open access: yes, 2017
We investigate structural resonances in multi-element optical resonators and provide a roadmap for the description of the interaction of single extended cavity modes with quantum emitters or mechanical resonators.
Dantan, Aurélien, Genes, Claudiu
core   +1 more source

tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes

open access: yesNucleic Acids Res., 2016
High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-
T. Lowe, Patricia P. Chan
semanticscholar   +1 more source

Estudio genético de una muestra poblacional del departamento de Bolivar con 10 marcadores ligados al cromosoma X

open access: yesIatreia, 2010
Los marcadores del cromosoma X se han utilizado en identificación humana y en pruebas de paternidad desde la década de los setenta, entre los más conocidos está el antígeno de los eritrocitos "Xgª", codificado por el gen del locus Xp22.32, y algunas ...
Beatriz Martínez   +7 more
doaj   +2 more sources

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