Results 71 to 80 of about 8,590,328 (320)
The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies
Journal of the American Statistical Association, 2017 It is of substantial interest to study the effects of genes, genetic pathways, and networks on the risk of complex diseases. These genetic constructs each contain multiple SNPs, which are often correlated and function jointly, and might be large in ...
I. Barnett, R. Mukherjee, Xihong Lin
semanticscholar +1 more source
Frontiers in Psychiatry, 2016 Suicidal behaviors (SBs), which range from suicidal ideation to suicide attempts and completed suicide, represent a fatal dimension of mental ill-health.
Bojan Mirkovic +5 more
semanticscholar +1 more source
Robust Tests in Genome-Wide Scans under Incomplete Linkage Disequilibrium [PDF]
, 2009 Under complete linkage disequilibrium (LD), robust tests often have greater power than Pearson's chi-square test and trend tests for the analysis of case-control genetic association studies.
Geller, Nancy +4 more
core +1 more source
Analysis of MMP2 promoter polymorphisms in childhood obesity
BMC Research Notes, 2011 Background Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of ...
Thompson John MD +4 more
doaj +1 more source
A weighted U statistic for association analysis considering genetic heterogeneity [PDF]
, 2015 Converging evidence suggests that common complex diseases with the same or similar clinical manifestations could have different underlying genetic etiologies. While current research interests have shifted toward uncovering rare variants and structural variations predisposing to human diseases, the impact of heterogeneity in genetic studies of complex ...
arxiv +1 more source
Incorporating prior information into association studies. [PDF]
, 2012 UnlabelledRecent technological developments in measuring genetic variation have ushered in an era of genome-wide association studies which have discovered many genes involved in human disease.
Darnell, Gregory +3 more
core +3 more sources
Robust Methods for Disease-Genotype Association in Genetic Association Studies: Calculate P-values Using Exact Conditional Enumeration instead of Asymptotic Approximations [PDF]
, 2013 In genetic association studies, detecting disease-genotype associations is a primary goal. For most diseases, the underlying genetic model is unknown, and we study seven robust test statistics for monotone association. For a given test statistic, there are many ways to calculate a p-value, but in genetic association studies, calculations have ...
arxiv +1 more source
GAS Power Calculator: web-based power calculator for genetic association studies
bioRxiv, 2017 Motivation: Statistical power calculations are crucial in designing genetic association studies. They help guide tradeoffs between large sample sizes and detailed assessments of genotype and phenotype, help determine which studies are viable, and help ...
Jennifer L. H. Johnson, G. Abecasis
semanticscholar +1 more source
Genetic Association Studies [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 The widespread availability of DNA from large population studies, the development of rapid throughput genotyping assays, and the identification of numerous polymorphisms in genes of interest make it easier to perform genetic association studies in humans. We consider these studies appropriate areas of research in relation to atherosclerosis, thrombosis,
openaire +5 more sources
Human Genomics, 2011 Type 2 diabetes represents an increasing health burden. Its prevalence is rising among younger age groups and differs among racial/ethnic groups. Little is known about its genetic basis, including whether there is a genetic basis for racial/ethnic ...
Klimentidis Yann C +5 more
doaj +1 more source