Results 71 to 80 of about 2,748,088 (370)

Analysis of the association between rs12917707 and rs11864909 single nucleotide polymorphisms in the region of the uromoduline gene and chronic kidney disease – a family-based study

Annals of Agricultural and Environmental Medicine, 2017
Chronic kidney disease (CKD) is an important challange for healthcare systems wordwide because of its high prevalence and serious late complications.
Joanna Żywiec, Katarzyna Kiliś-Pstrusińska, Maciej Tomaszewski, Władysław Grzeszczak   +3 more
doaj   +1 more source

Association of Genetic Variation With Keratoconus [PDF]

JAMA Ophthalmology, 2020
Keratoconus is a condition in which the cornea progressively thins and protrudes in a conical shape, severely affecting refraction and vision. It is a major indication for corneal transplant. To discover new genetic loci associated with keratoconus and better understand the causative mechanism of this disease, we performed a genome-wide association ...
Jamie E Craig, Jamie E Craig, Paul N. Baird, Kent D. Taylor, Kent D. Taylor, Jerome I. Rotter, Jerome I. Rotter, Stuart MacGregor, David A. Mackey, Bennet J. McComish, Jie Jin Wang, Richard A. Mills, Kathryn P. Burdon, Kathryn P. Burdon, Srujana Sahebjada, Andrea J. Richardson, Yelena Bykhovskaya, Jac Charlesworth, Alex W. Hewitt, Colin E. Willoughby, Colin E. Willoughby, Sionne E. M. Lucas, Abi Tenen, Richard A. Jensen, Yaron S. Rabinowitz, Xiaohui Li, Xiaohui Li, Paul Mitchell   +27 more
openaire   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia. [PDF]

, 2012
Schizophrenia is a severe psychiatric disorder with strong heritability and marked heterogeneity in symptoms, course, and treatment response. There is strong interest in identifying genetic risk factors that can help to elucidate the pathophysiology and ...
Campbell, CR, Cirulli, ET, Ge, D, Gennarelli, M, Goldstein, DB, Gumbs, CE, Hallikainen, T, He, M, Heinzen, EL, Hong, L, Levy, DL, Maia, JM, McEvoy, JP, Meltzer, HY, Need, AC, Putkonen, A, Repo-Tiihonen, E, Rosenquist, P, Shianna, KV, Tiihonen, J, Zhao, Q   +20 more
core   +1 more source

Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations

Frontiers in Genetics, 2019
Background: Esophageal squamous cell carcinoma (ESCC), one of the most aggressive cancers, is endemic in Sub-Saharan Africa, constituting a major health burden.
Hannah Simba, Helena Kuivaniemi, Vittoria Lutje, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Vikash Sewram   +8 more
doaj   +1 more source

Polygenic Risk Score Prediction for Endometriosis

Frontiers in Reproductive Health, 2021
Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization.
Kirstine Kloeve-Mogensen, Kirstine Kloeve-Mogensen, Palle Duun Rohde, Palle Duun Rohde, Simone Twisttmann, Marianne Nygaard, Kristina Magaard Koldby, Rudi Steffensen, Christian Møller Dahl, Dorte Rytter, Michael Toft Overgaard, Axel Forman, Lene Christiansen, Lene Christiansen, Mette Nyegaard, Mette Nyegaard   +15 more
doaj   +1 more source

Genetic Association Studies [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
The widespread availability of DNA from large population studies, the development of rapid throughput genotyping assays, and the identification of numerous polymorphisms in genes of interest make it easier to perform genetic association studies in humans. We consider these studies appropriate areas of research in relation to atherosclerosis, thrombosis,
openaire   +5 more sources

Editorial: Genetic association studies in oil seeds. [PDF]

Front Genet
Shobhana VG, Kirubakaran SJP, Li S, Parthiban TP.   +3 more
europepmc   +2 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations. [PDF]

, 2018
Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans.
Akafo, Stephen K, Allingham, R Rand, Ashaye, Adeyinka O, Belbin, Gillian M, Bonnemaijer, Pieter WM, Bottinger, Erwin P, Cook, Colin, Eyes of Africa Genetics Consortium, GIGA Study Group, Girkin, Christopher A, Hammond, Christopher J, Hassan, Hassan G, Hauser, Michael A, Hysi, Pirro G, Iglesias, Adriana I, Kenny, Eimear E, Klaver, Caroline CW, Lemij, Hans G, Li, Zheng, Loos, Ruth JF, Meester-Smoor, Magda A, Nadkarni, Girish N, Nag, Abhishek, NEIGHBORHOOD Consortium, Ng, Maggie CY, Rotter, Jerome I, Sanyiwa, Anna J, Schurmann, Claudia, Simcoe, Mark, Taylor, Kent D, Thiadens, Alberta AHJ, van de Laar, Suzanne, van Duijn, Cornelia M, Weinreb, Robert N, Wiggs, Janey L, Wiliams, Susan EI, Zangwill, Linda M   +36 more
core