Results 21 to 30 of about 273,398 (272)
Extensive breaking of genetic code degeneracy with non-canonical amino acids
Nature Communications, 2023 Genetic code expansion (GCE) offers many exciting opportunities for the creation of synthetic organisms and for drug discovery methods that utilize in vitro translation.
Clinton A. L. McFeely +5 more
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An Ecological Basis for Dual Genetic Code Expansion in Marine Deltaproteobacteria
Frontiers in Microbiology, 2021 Marine benthic environments may be shaped by anthropogenic and other localized events, leading to changes in microbial community composition evident decades after a disturbance.
Veronika Kivenson +2 more
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Unconventional genetic code systems in archaea
Frontiers in Microbiology, 2022 Archaea constitute the third domain of life, distinct from bacteria and eukaryotes given their ability to tolerate extreme environments. To survive these harsh conditions, certain archaeal lineages possess unique genetic code systems to encode either ...
Kexin Meng +4 more
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Expansion of the genetic code via expansion of the genetic alphabet [PDF]
Current Opinion in Chemical Biology, 2018 Current methods to expand the genetic code enable site-specific incorporation of non-canonical amino acids (ncAAs) into proteins in eukaryotic and prokaryotic cells. However, current methods are limited by the number of codons possible, their orthogonality, and possibly their effects on protein synthesis and folding.
Vivian T Dien +3 more
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Frontiers in Molecular Biosciences, 2022 Amino acid sequences of proteins are encoded in nucleic acids composed of four letters, A, G, C, and T(U). However, this four-letter alphabet coding system limits further functionalities of proteins by the twenty letters of amino acids.
Michiko Kimoto, Ichiro Hirao
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Inducible Genetic Code Expansion in Eukaryotes
ChemBioChem, 2020 AbstractGenetic code expansion (GCE) is a versatile tool to site‐specifically incorporate a noncanonical amino acid (ncAA) into a protein, for example, to perform fluorescent labeling inside living cells. To this end, an orthogonal aminoacyl‐tRNA‐synthetase/tRNA (RS/tRNA) pair is used to insert the ncAA in response to an amber stop codon in the protein
Christine Koehler +3 more
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Genetic Code Expansion Tools to Study Lysine Acylation [PDF]
Advanced Biology, 2021 AbstractLysine acylation is a ubiquitous protein modification that controls various aspects of protein function, such as the activity, localization, and stability of enzymes. Mass spectrometric identification of lysine acylations has witnessed tremendous improvements in sensitivity over the last decade, facilitating the discovery of thousands of lysine
Petra Neumann‐Staubitz +2 more
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Genetic Code Expansion: Another Solution to Codon Assignments. [PDF]
Int J Mol Sci, 2022 This Special Issue is intended to highlight recent advances in genetic code expansion, particularly the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins [...]
Sakamoto K.
europepmc +3 more sources
Genetic‐Code‐Expansion Strategies for Vaccine Development
ChemBioChem, 2020 AbstractAbstract: By providing long‐term protection against infectious diseases, vaccinations have significantly reduced death and morbidity worldwide. In the 21st century, (bio)technological advances have paved the way for developing prophylactic vaccines that are safer and more effective as well as enabling the use of vaccines as therapeutics to ...
Jelle A. Fok, Clemens Mayer
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The Alanine World Model for the Development of the Amino Acid Repertoire in Protein Biosynthesis [PDF]
, 2019 A central question in the evolution of the modern translation machinery is the origin and chemical ethology of the amino acids prescribed by the genetic code.
Budisa, Nediljko, Kubyshkin, Vladimir
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