Results 1 to 10 of about 98,886 (139)

Genetics, Epigenetics, and Leukemia [PDF]

New England Journal of Medicine, 2010
In this issue of the Journal, Ley and colleagues1 report that somatic mutations in a gene encoding a DNA methyltransferase, DNMT3A, are common in adults with acute myeloid leukemia (AML). They also report that these mutations are associated with discrete molecular and cytogenetic features that have prognostic significance.
Kevin, Shannon, Scott A, Armstrong
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Genetics and Epigenetics in Asthma [PDF]

International Journal of Molecular Sciences, 2021
Asthma is one of the most common respiratory disease that affects both children and adults worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly understood. As technology in genome sequencing progressed, scientific efforts were made to explain and predict asthma’s complexity and heterogeneity, and genome-wide association ...
Polyxeni Ntontsi, Andreas Photiades, Eleftherios Zervas, Georgina Xanthou, Konstantinos Samitas   +4 more
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Non-mammalian model organisms in epigenetic research : an overview [PDF]

, 2020
Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik, Bossier, Peter, Norouzitallab, Parisa, Vanrompay, Daisy   +3 more
core   +2 more sources

Determining the quality and complexity of next-generation sequencing data without a reference genome [PDF]

, 2014
Genomics, epigenetics, population genetics and ...
Irina Pulyakhina, Jeroen FJ Laros, Johan T den Dunnen, Ken Kraaijeveld, Lusine Khachatryan, Martijn Vermaat, Michiel van Galen, Peter AC ’t Hoen, Peter de Knijff, Seyed Yahya Anvar, Yavuz Ariyurek   +10 more
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Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle? [PDF]

, 2013
DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely required for the expression of many viral genes.
Sinclair, Alison J
core   +4 more sources

The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene's eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution [PDF]

, 2018
Studying the phenotypic evolution of organisms in terms of populations of genes and genotypes, the Modern Synthesis (MS) conceptualizes biological evolution in terms of 'inter-organismal' interactions among genes sitting in the different individual ...
Blancke, Stefaan, Braeckman, Johan, De Tiège, Alexis   +2 more
core   +3 more sources

Synthesizing the role of epigenetics in the response and adaptation of species to climate change in freshwater ecosystems [PDF]

, 2018
Freshwater ecosystems are amongst the most threatened ecosystems on Earth. Currently, climate change is one of the most important drivers of freshwater transformation and its effects include changes in the composition, biodiversity and functioning of ...
Allen, Allendorf, Alley, Andrewartha, Anway, Araújo, Ardura, Artemov, Asselman, Asselman, Avise, Baccarelli, Baerwald, Baudo, Bell, Berg, Bernardi, Bernstein, Bianchini, Bind, Bird, Bird, Blake, Bossdorf, Boutin, Brander, Bräutigam, Burggren, Bush, Carpenter, Cañedo-Argüelles, Chown, Clarke, Corcoran, Crozier, Dai, Dallas, Daxinger, Denissenko, Detrich, Dudgeon, Durance, Eros, Fasola, Feil, Fenoglio, Foley, Friberg, Fulneček, Garg, Gienapp, Glastad, Goldberg, Gonçalves, Guillette, Hanson, Harris, Heino, Henry, Hering, Hernando-Herraez, Ho, Hoegh-Guldberg, Hoffmann, Hu, Jabbari, Jablonka, Jackson, Jackson, Jaenisch, Janssens, Jiang, Karell, Karr, Kefford, Keller, Kelly, Klimenko, Klironomos, Kouzarides, Kronholm, Kronholm, Kumar, Kurdyukov, Laland, Laland, Lan, Latta, Leung, Lighten, Liu, Loureiro, Loureiro, Lämke, Manjrekar, Markovic, Martinez-Sales, Martínez-Jerónimo, Matthews, Mattick, Meissner, Mendizabal, Merilä, Merilä, Michener, Mimura, Minshull, Mirbahai, Mohseni, Moore, Mudbhary, Mulholland, Munday, Nabel, Nielsen, Norouzitallab, Parichy, Park, Pestana, Peterson, Pigliucci, Pigliucci, Pu, Qu, Rey, Ribeiro, Rinn, Ryan, Sarda, Scheiner, Scheiner, Schindler, Schrey, Shaw, Shea, Solan, Srinageshwar, Stief, Sun, Suter, Suzuki, Szabo, Sáez, Urich, Vandegehuchte, Vandegehuchte, Vannier, Varriale, Varriale, Varriale, Venâncio, Verhoeven, Verhoeven, Vogt, Vogt, Vogt, Wang, Wang, Weider, Weinberg, Weyrich, Willbanks, Williams, Wong, Woodward, Woodward, WWAP   +166 more
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Mitochondrial Genetics and Epigenetics in Osteoarthritis [PDF]

Frontiers in Genetics, 2020
During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial genetic polymorphisms, specifically the mitochondrial DNA haplogroups, have been shown to have an important influence on different OA-related ...
Rego-Pérez, I., Durán-Sotuela, Alejandro, Ramos-Louro, Paula, Blanco García, Francisco J   +3 more
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Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes. [PDF]

, 2017
Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics analysis to evaluate the utility
A Brazma, A Nan, A Okuhara, A Turchinovich, B Aryal, B Mayr, B Sharif, B Zhang, BM Bolstad, BM Kuhn, BM Mayr, C Beyer, C Chen, C Guay, C Taurino, CL Andersen, D Dlouha, D Iliopoulos, D Zhang, DT Felson, F Kostopoulou, FE Nicolas, G Dennis Jr, G Li, G Tardif, GD Miles, GR Sondag, GS Lien, H Causton, JB van Meurs, JD Storey, JD Storey, KC Vickers, L Qi, M Cross, M Parrizas, MB Goldring, MC Hochberg, MD Paraskevopoulou, MP Gantier, OF Laterza, Q Zhuo, R Gernapudi, RF Loeser, RI Gregory, S Kluzek, S Kumar, S Miyaki, T Thomou, TA Karlsen, VM Borgonio Cuadra, W Cleveland, WM Reichmann, X Chen, X Chen, X Tan, X Wang, Y Klipper-Aurbach, Y Zhang, YH Li   +59 more
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Lung cancer epigenetics and genetics [PDF]

International Journal of Cancer, 2008
AbstractLung cancer is the leading cause of cancer‐related death and thus a major health problem. The efficiency of current treatment modalities for lung cancer depends strongly on the time of diagnosis, with better chances of survival if a tumor has been detected at an early stage.
Angela, Risch, Christoph, Plass
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