Genetics and epigenetics in obesity [PDF]
Metabolism, 2019 Obesity is among the most threatening health burdens worldwide and its prevalence has markedly increased over the last decades. Obesity maybe considered a heritable trait. Identifications of rare cases of monogenic obesity unveiled that hypothalamic circuits and the brain-adipose axis play an important role in the regulation of energy homeostasis ...
Rohde, Kerstin +5 more
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The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened
Nature Communications, 2022 DNAPKcs and its kinase activity are required for blunt DNA break end joining when the bridging factor XLF is weakened, but for homologous recombination and radiation resistance, the influence of DNAPKcs is not further enhanced with loss of XLF.
Metztli Cisneros-Aguirre +4 more
doaj +1 more source
Editorial: The genetics and epigenetics of mental health. [PDF]
Front GenetKretzschmar GC, Boldt ABW, Targa ADS.
europepmc +2 more sources
Studying the factors affecting human genetics due to environmental degradation and climate change [PDF]
BIO Web of Conferences, 2023 Environmental degradation and climate change have significant impacts on human genetics. The article examines the factors affecting human genetics due to these changes.
Mirsaidova Khilola +2 more
doaj +1 more source
Role of enhancer of zeste homolog 2 polycomb protein and its significance in tumor progression and cell differentiation [PDF]
, 2013 Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2].
Bagella, Luigi Marco, Marchesi, Irene
core +2 more sources
Genetics and epigenetics of inflammatory bowel disease
Swiss Medical Weekly, 2018 The relevance of genetic and epigenetic alterations in the pathogenesis of inflammatory bowel disease (IBD) is still poorly understood. So far, 240 risk gene loci have been associated with IBD. They are mainly involved in regulating innate and adaptive
Marcin Wawrzyniak, Michael Scharl
doaj +1 more source
Editorial: Genetics and epigenetics of fetal alcohol spectrum disorders [PDF]
Frontiers in Genetics, 2015 Mason, Stephen, Zhou, Feng C
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Human genetics and epigenetics of alcohol use disorder. [PDF]
J Clin InvestAlcohol use disorder (AUD) is a prominent contributor to global morbidity and mortality. Its complex etiology involves genetics, epigenetics, and environmental factors.
Zhou H, Gelernter J.
europepmc +2 more sources
Chondrosarcoma: biology, genetics, and epigenetics [PDF]
F1000Research, 2018 Chondrosarcomas constitute a heterogeneous group of primary bone cancers characterized by hyaline cartilaginous neoplastic tissue. They are the second most common primary bone malignancy. The vast majority of chondrosarcomas are conventional chondrosarcomas, and most conventional chondrosarcomas are low- to intermediate-grade tumors (grade 1 or 2 ...
openaire +4 more sources
Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis [PDF]
, 2018 Background. The lead (Pb) exposure crisis in Flint, Michigan has passed from well-publicized event to a footnote, while its biological and social impact will linger for lifetimes.
Bayon, Baindu L. +3 more
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