Results 51 to 60 of about 98,968 (210)

Genome-wide association study (GWAS) approaches to sleep phenotypes [PDF]

, 2013
Patrick Sleiman, Michael March, Hákon Hákonarson   +2 more
openalex   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Providing Personalized Genetic Feedback for Psychiatric and Substance Use Disorders: An Urgent Need for Research

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
Danielle M. Dick, Jehannine (J9) Austin
wiley   +1 more source

Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Converging evidence from neuroimaging studies and genome‐wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit‐specific genes in the development of the AN‐like phenotype remains ...
K. Huang, M. A. Magateshvaren Saras, K. Conn, E. Greaves, F. Reed, S. Tyagi, H. Munguba, C. J. Foldi   +7 more
wiley   +1 more source

Parallel Increase in Childhood Anorexia Nervosa and Early Puberty During the COVID‐19 Pandemic

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective During the COVID‐19 pandemic, an increase in anorexia nervosa (AN), specifically childhood AN, as well as in central precocious puberty (CPP) and early‐onset puberty (EOP), was reported. The aim of this study was to explore whether there was a population‐level association between increases in both disorders and to discuss possible ...
Beate Herpertz‐Dahlmann, Astrid Dempfle, Stefan Eckardt, Josef Neulen, Kelly L. Klump   +4 more
wiley   +1 more source

Genome-wide association study (GWAS) of circulating vitamin D outcomes among individuals of African ancestry. [PDF]

Am J Clin Nutr, 2023
Parlato LA, Welch R, Ong IM, Long J, Cai Q, Steinwandel MD, Blot WJ, Zheng W, Warren Andersen S.   +8 more
europepmc   +1 more source

LMM-22: An Enhanced Linear Mixed Model (LMM) Approach for Genome-Wide Association Studies (GWAS) for the Prediction of Diseases and Traits among Humans from Genomics Data

, 2020
Siddharth Sharma
openalex   +2 more sources

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

Genome-wide association studies (GWAS) have revolutionized our view of human health and disease genetics and offered novel gene therapy targets

, 2021
Moataz Dowaidar
openalex   +1 more source

Early diagnostic value of novel biomarkers for breast cancer therapy‐related cardiac dysfunction

ESC Heart Failure, EarlyView.
Our meta‐analysis revealed significant post‐treatment increases in GDF‐15, CRP, MPO, and PLGF levels (Gal‐3 unchanged) among breast cancer patients. Only elevated MPO levels were significantly associated with an increased risk of cancer therapy‐related cardiac dysfunction (CTRCD).
Zhengwei Wang, Yujuan Wu, Jingyi He, Diansa Gao, Zhong Zuo   +4 more
wiley   +1 more source