Results 71 to 80 of about 3,929,879 (390)
The GB4.0 Platform, an All-In-One Tool for CRISPR/Cas-Based Multiplex Genome Engineering in Plants
Frontiers in Plant Science, 2021 CRISPR/Cas ability to target several loci simultaneously (multiplexing) is a game-changer in plant breeding. Multiplexing not only accelerates trait pyramiding but also can unveil traits hidden by functional redundancy. Furthermore, multiplexing enhances
Marta Vazquez-Vilar +12 more
doaj +1 more source
Bacteria herald a new era of gene editing. [PDF]
, 2013 The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landmark in the rapidly developing field of genome ...
Segal, David J
core
Genome engineering technologies in rabbits
The Journal of Biomedical Research, 2021 The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates. However, the technology for precise genome manipulations in rabbit has been stalled for decades, severely limiting its applications in biomedical research.
Song, J +5 more
openaire +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Removal of a Subset of Non-essential Genes Fully Attenuates a Highly Virulent Mycoplasma Strain
Frontiers in Microbiology, 2019 Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants.
Joerg Jores +22 more
doaj +1 more source
Dissecting the Biological Motherboard (Systems Biology and Beyond) [PDF]
, 2008 Genome-scale molecular networks, including gene pathways, gene regulatory networks and protein interactions, are central to the investigation of the nascent disciplines of systems biology and bio-complexity.
Abhay Krishna, Ajit Narayanan
core +2 more sources
Materials Genome Engineering AdvancesThe emerging photovoltaic (PV) technologies, such as organic and perovskite PVs, have the characteristics of complex compositions and processing, resulting in a large multidimensional parameter space for the development and optimization of the ...
Ying Shang +5 more
semanticscholar +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
CRISPR–Cas9 Genetic Analysis of Virus–Host Interactions
Viruses, 2018 Clustered regularly interspaced short palindromic repeats (CRISPR) has greatly expanded the ability to genetically probe virus–host interactions. CRISPR systems enable focused or systematic, genomewide studies of nearly all aspects of a virus lifecycle ...
Makda Gebre +2 more
doaj +1 more source
Advances and Opportunities of CRISPR/Cas Technology in Bioengineering Non-conventional Yeasts
Frontiers in Bioengineering and Biotechnology, 2021 Non-conventional yeasts have attracted a growing interest on account of their excellent characteristics. In recent years, the emerging of CRISPR/Cas technology has improved the efficiency and accuracy of genome editing. Utilizing the advantages of CRISPR/
Lu Shan +5 more
doaj +1 more source