Results 21 to 30 of about 120,679 (294)

Caspase Mediated Enhanced Apoptotic Action of Cyclophosphamide- and Resveratrol-Treated MCF-7 Cells

Journal of Pharmacological Sciences, 2009
Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer.
Neetu Singh, Manisha Nigam, Vishal Ranjan, Ramesh Sharma, Anil Kumar Balapure, Srikanta Kumar Rath   +5 more
doaj   +1 more source

Evaluation of extracts of wild Cannabis sativa L. for genotoxicity and phytochemical composition

Caryologia, 2021
Cannabis sativa L. is used as medicine and narcotic in Lesotho. Phytochemical composition and total phenolics content (TPC) for hexane, chloroform, ethyl acetate a methanol extracts of aerial parts of C. sativa were determined.
Asita Asita, Sibusisiwe Magama, Thato Moahloli, Selometsi Baholo   +3 more
doaj   +1 more source

Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]

, 2006
The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Devaux, Alain, Ferrier, Vincent, Gauthier, Laury, Jourdain, Marie-José, Mailhes, Corinne, Mouchet, Florence, Triffault, Gaëlle   +6 more
core   +1 more source

Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]

, 2017
Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena, Barile, Fabio, Bozovic, Mijat, DI GIACOMO, Silvia, DI SOTTO, Antonella, Izzo, Angelo A, Mazzanti, Gabriela, Parisi, Olga A, Ragno, Rino, Vitalone, Annabella   +9 more
core   +1 more source

Nanomaterial genotoxicity evaluation using the high-throughput p53-binding protein 1 (53BP1) assay.

PLoS ONE, 2023
Toxicity evaluation of engineered nanomaterials is challenging due to the ever increasing number of materials and because nanomaterials (NMs) frequently interfere with commonly used assays.
Maelle Fontaine, Eline Bartolami, Marion Prono, David Béal, Magda Blosi, Anna L Costa, Costanza Ravagli, Giovanni Baldi, Simone Sprio, Anna Tampieri, Ivana Fenoglio, Lang Tran, Bengt Fadeel, Marie Carriere   +13 more
doaj   +1 more source

Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]

, 2011
This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
Polard, Thierry, Jean, Séverine, Merlina, Georges, Laplanche, Christophe, Pinelli, Eric, Gauthier, Laury   +5 more
core   +2 more sources

Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes [PDF]

, 2014
The contamination of food commodities by fungal toxins has attracted great interest because many of these mycotoxins are responsible for different diseases, including cancer and other chronic illnesses. Ochratoxin A (OTA) is a mycotoxin naturally present
Barrón-Vivanco, Briscia S., Benitez-Trinidad, alma B., González Arias, Cyndia A., Marín Sillué, Sònia, Medina-Díaz, Irma M., Ramos Girona, Antonio J., Robledo-Marenco, Lourdes, Rojas-García, A. E., Sanchís Almenar, Vicente, Sordo, Montserrat   +9 more
core   +2 more sources

Is the Comet Assay a Sensitive Procedure for Detecting Genotoxicity?

Journal of Nucleic Acids, 2010
Although the Comet assay, a procedure for quantitating DNA damage in mammalian cells, is considered sensitive, it has never been ascertained that its sensitivity is higher than the sensitivity of other genotoxicity assays in mammalian cells. To determine
Satomi Kawaguchi, Takanori Nakamura, Ayumi Yamamoto, Gisho Honda, Yu F. Sasaki   +4 more
doaj   +1 more source

A Novel Strategy to Predict Carcinogenicity of Antiparasitics Based on a Combination of DNA Lesions and Bacterial Mutagenicity Tests

Frontiers in Public Health, 2017
Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu, Zhixin Lei, Feng Zhu, Awais Ihsan, Xu Wang, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan   +7 more
doaj   +1 more source

Scientific Opinion on Flavouring Group Evaluation 7, Revision 5 (FGE.07Rev5) : saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 [PDF]

, 2017
Acknowledgements: The Panel wishes to thank the members of the Working Group on Flavourings: Ulla Beckman Sundh, Leon Brimer, Karl-Heinz Engel, Paul Fowler, Rainer Gürtler, Trine Husøy, Wim Mennes and Gerard Mulder for the preparatory work on this ...
Anastassiadou, Maria, Bolognesi, Claudia, Brimer, Leon, Castle, Laurence, Cravedi, Jean-Pierre, de Fátima Tavares Poças, Maria, EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler , Paul, Franz, Roland, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kärenlampi, Sirpa, Mennes, Wim, Mosesso, Pasquale, Mulder, Gerard, Penninks, André, Rosaria Milana, Maria, Silano, Vittorio, Smith, Andrew, Sundh, Ulla Beckman, Tlustos, Christina, Wölfle , Detlef, Zorn, Holger, Zugravu, Corina-Aurelia   +25 more
core   +2 more sources