Results 11 to 20 of about 380,405 (282)

Diagnosis of hepatitis C virus genotype 2k/1b needs NS5B sequencing [PDF]

International Journal of Infectious Diseases, 2015
Hepatitis C virus (HCV) is probably the most common cause of liver cirrhosis and hepatocellular carcinoma worldwide. The correct identification of HCV genotype has important clinical implications as a marker of responsiveness to antiviral therapy and ...
Steven De Keukeleire, Patrick Descheemaeker, Marijke Reynders   +2 more
doaj   +3 more sources

NS4A protein as a marker of HCV history suggests that different HCV genotypes originally evolved from genotype 1b [PDF]

Virology Journal, 2011
Background The 9.6 kb long RNA genome of Hepatitis C virus (HCV) is under the control of RNA dependent RNA polymerase, an error-prone enzyme, for its transcription and replication.
Asad Sultan, Ashfaq Usman A, Sumrin Aleena, Ansar Muhammad, Ahmad Waqar, Ijaz Bushra, Kausar Humera, Sarwar Muhammad T, Gull Sana, Shahid Imran, Hassan Sajida   +10 more
doaj   +3 more sources

Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection. [PDF]

Hepatology, 2014
All-oral combinations of direct-acting antivirals may improve efficacy and safety outcomes for patients with hepatitis C virus (HCV) infection, particularly those who are poor candidates for current interferon/ribavirin-based regimens.
Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, Kawakami Y, Ido A, Yamamoto K, Takaguchi K, Izumi N, Koike K, Takehara T, Kawada N, Sata M, Miyagoshi H, Eley T, McPhee F, Damokosh A, Ishikawa H, Hughes E.   +20 more
europepmc   +4 more sources

HCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b [PDF]

BMC Gastroenterology, 2012
The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respond differently to treatment with PEGylated ...
Adriano M. Pellicelli, Mario Romano, Tommaso Stroffolini, Ettore Mazzoni, Fabrizio Mecenate, Roberto Monarca, Antonio Picardi, Maria Bonaventura, Cristina Mastropietro, Pascal Vignally, Arnaldo Andreoli, Massimo Marignani, Cecilia D'Ambrosio, Lucia Miglioresi, Lorenzo Nosotti, Olga Mitidieri, Umberto Gentilucci, Claudio Puoti, Giuseppe Barbaro, Angelo Barlattani, FURLAN, Caterina, G. Cleo Gorup Brbarini   +21 more
openaire   +3 more sources

A Unique Genotype of Pseudohypoaldosteronism Type 1b in a Highly Consanguineous Population [PDF]

Journal of the Endocrine Society, 2021
Abstract Context Pseudohypoaldosteronism (PHA) is a condition in which serum aldosterone level is normal or elevated but its action is deficient. Objective This study describes the molecular genetics of PHA 1b in the highly ...
Ali S Alzahrani, Meshael Alswailem, Bassam Bin Abbas, Ebtesam Qasem, Afaf Alsagheir, Azza Al Shidhani, Aisha Al Sinani, Maryam Al Badi, Ali Al-Maqbali, Manal Al Shawi, Abdulhameed Albunyan, Abdulghani Bin Nafisah, Yufei Shi   +12 more
openaire   +2 more sources

Genotype distribution in chronic hepatitis C, relationship of genotype with HCV RNA, alpha fetoprotein, alanine aminotransferase and liver fibrosis

Medicine Science, 2021
In this study, the genotype distribution in chronic hepatitis C (CHC) and its relationship with alanine aminotransferase (ALT), alpha fetoprotein (AFP), HCV RNA and liver fibrosis were compared. HCV RNA was negative in 63 and positive in 69 CHC cases who
Arzu Senol, Ozlem Aytac
doaj   +1 more source

Genomic characterization of Brazilian hepatitis C virus genotypes 1a and 1b [PDF]

Brazilian Journal of Medical and Biological Research, 1997
Parts of 5' non-coding (5' NC) and of E1 envelope regions of the hepatitis C virus (HCV) genome were amplified from sera of 26 Brazilian anti-HCV antibody-positive patients using the reverse transcription-polymerase chain reaction (RT-PCR). Fourteen samples were PCR positive with primers from the 5' NC region and 8 of them were also positive with ...
M.G. Peig Ginabreda, C.F.T. Yoshida, C. Niel   +2 more
openaire   +3 more sources

Next-generation sequencing analysis of hepatitis C virus resistance–associated substitutions in direct-acting antiviral failure in South Korea [PDF]

Clinical and Molecular Hepatology, 2023
Background/Aims We used next-generation sequencing (NGS) to analyze resistance-associated substitutions (RASs) and retreatment outcomes in patients with chronic hepatitis C virus (HCV) infection who failed direct-acting antiviral agent (DAA) treatment in
Kyung-Ah Kim, Sejoon Lee, Hye Jung Park, Eun Sun Jang, Youn Jae Lee, Sung Bum Cho, Young Suk Kim, In Hee Kim, Byung Seok Lee, Woo Jin Chung, Sang Hoon Ahn, Seungtaek Kim, Sook Hyang Jeong   +12 more
doaj   +1 more source

Hepatitis C virus genotypes in liver transplant recipients: Impact on posttransplant recurrence, infections, response to interferon-α therapy and outcome [PDF]

, 1997
Background. End-stage liver disease due to hepatitis C virus (HCV) is the most common indication for liver transplantation in U.S. veterans. We investigated the influence of HCV genotypes on the incidence and timing of recurrent HCV hepatitis, survival ...
Fung, JJ, Gayowski, T, Laskus, T, Marino, IR, Morelli, F, Rakela, J, Singh, N, Starzl, TE, Vargas, H, Wagener, M, Wannstedt, C   +10 more
core   +1 more source

Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2013
The discovery of potent thienoimidazole-based HCV NS5A inhibitors is herein reported. A novel method to access the thienoimidazole [5,5]-bicyclic system is disclosed. This method gave access to a common key intermediate (6) that was engaged in Suzuki or Sonogashira reactions with coupling partners bearing different linkers.
Simon, Giroux, Jinwang, Xu, T Jagadeeswar, Reddy, Mark, Morris, Kevin M, Cottrell, Caroline, Cadilhac, James A, Henderson, Oliver, Nicolas, Darius, Bilimoria, Francois, Denis, Nagraj, Mani, Nigel, Ewing, Rebecca, Shawgo, Lucille, L'Heureux, Subajini, Selliah, Laval, Chan, Nathalie, Chauret, Francoise, Berlioz-Seux, Mark N, Namchuk, Anne-Laure, Grillot, Youssef L, Bennani, Sanjoy K, Das, John P, Maxwell   +22 more
openaire   +2 more sources