Gut and Liver, 2017 Background/AimsChronic hepatitis C (CHC) is a major comorbidity in patients with hemophilia.Methods : Patients (n=30) were enrolled between September 2015 and April 2016.
Hyun Woong Lee +3 more
doaj +1 more source
Multiple effects of silymarin on the hepatitis C virus lifecycle [PDF]
, 2010 Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo.
Bourne, Nigel +16 more
core +1 more source
Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]
, 2021 Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G +13 more
core +1 more source
Hepatitis C virus (HCV) genotype 1b displays higher genetic variability of hypervariable region 1 (HVR1) than genotype 3. [PDF]
Sci Rep, 2019 AbstractHepatitis C virus (HCV) is characterized by high genetic variability, which is manifested both at the inter-host and intra-host levels. However, its role in the clinical course of infection is less obvious. The aim of the present study was to determine the genetic variability of HCV HVR1 (hypervariable region 1) of genotype 1b and 3 in plasma ...
Janiak M +11 more
europepmc +5 more sources
Thrombocytopenia in pegylated interferon and ribavirin combination therapy for chronic hepatitis C [PDF]
, 2013 BACKGROUND: This study aimed to examine the therapeutic effect and prognostic indicators of pegylated interferon (PEG-IFN) and ribavirin (RBV) combination therapy in thrombocytopenic patients with chronic hepatitis C, hepatitis C virus (HCV)-related ...
Hirayuki Enomoto +11 more
core +1 more source
Hepatitis C virus genotype 1b chimeric replicon containing genotype 3 NS5A domain
Virology, 2006 Infections with hepatitis C virus (HCV) genotype 3 exhibit differences in clinical phenotype including an increase in response to interferon therapy and development of steatosis. To initiate studies on genotype 3, we created a chimeric genotype 1b replicon containing a genotype 3a NS5A domain. The chimera was capable of efficient colony formation after
Lanford, Robert E. +2 more
openaire +2 more sources
An impact of CYP3A4 *1B polymorphism on rifampicin metabolism
Journal of Education, Health and Sport, 2017 Until now, the enzyme systems responsible for biotransformation of the antituberculous drug rifampicin remain unknown. The aim of research was an investigation of the candidate enzymes involved in the biotransformation of rifampicin using the computer ...
H. O. Poludenko, P. B. Antonenko
doaj +3 more sources
Serendipitous identification of natural intergenotypic recombinants of hepatitis C in Ireland [PDF]
, 2013 Background: Recombination between hepatitis C single stranded RNA viruses is a rare event. Natural viable intragenotypic and intergenotypic recombinants between 1b-1a, 1a-1c and 2k-1b, 2i-6p, respectively, have been reported.
Crosbie, Orla +6 more
core +1 more source
SVR Rates of HCV-infected population under PEG-IFN-α/R treatment in Northwest China [PDF]
, 2017 BACKGROUND: Chronic HCV Patients taking PEG-IFN-α/R from different ethnic groups have different probabilities of reaching a sustained viral response (SVR).
Bin Xu +8 more
core +1 more source
Viral Hepatitis Journal, 2017 ObjectiveHepatitis C virus (HCV) is responsible for 20% of acute hepatitis and 70% of chronic hepatitis. Determination of HCV genotype is important in the regulation of treatment and the followup of clinical course.
Ülkü ORAL ZEYTİNLİ +5 more
doaj +1 more source